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PNRC2 (NM_017761) Human Untagged Clone

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SKU
SC321359
PNRC2 (untagged)-Human proline-rich nuclear receptor coactivator 2 (PNRC2)
  $150.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol PNRC2
Vector pCMV6-AC
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_017761.2 AGAAGGAGAAGGTCGGGTTGTAGAAGCTGGGGTGGCCGGCAGCTCGCTCATCGGTGTTCG
TGGGCTTTGTCGGTCCGTGCCTCGTCTCTCCCTGGAAAGGGAGGGAGGCTTCGACGTCGA
GAGGGAGCCGCTGCCGCGTTAGTTCCGAGCTTGAAGTCACTAGGACTTCTCTCAAACTTG
TGTGCTGAGGAGACTCAGATGTTGGCCTCAGCTCCTAGGCTGAACTCAGCAGATCGGCCC
ATGAAAACTTCTGTATTGAGACAAAGGAAGGGATCTGTCAGAAAGCAACACTTGTTATCT
TGGGCTTGGCAGCAAGGAAGAGGACAGGTAGTGGAGATCCTGCAATCTGAAAAGCAGACT
GAAAGGTGACAAAGAAGCTGAAGATGGGTGGTGGAGAGAGGTATAACATTCCAGCCCCTC
AATCTAGAAATGTTAGTAAGAACCAACAACAGCTTAACAGACAGAAGACCAAGGAACAGA
ATTCCCAGATGAAGATTGTTCATAAGAAAAAAGAAAGAGGACATGGTTATAACTCATCAG
CAGCTGCCTGGCAGGCCATGCAAAATGGGGGGAAGAACAAAAATTTTCCAAATAATCAAA
GTTGGAATTCTAGCTTATCAGGTCCCAGGTTACTTTTTAAATCTCAAGCTAATCAGAACT
ATGCTGGTGCCAAATTTAGTGAGCCGCCATCACCAAGTGTTCTTCCCAAACCACCAAGCC
ACTGGGTCCCTGTTTCCTTTAATCCTTCAGATAAGGAAATAATGACATTTCAACTTAAAA
CCTTACTTAAAGTACAGGTATAAAATAAGACAAATGTTTAAATTTAGTTATGTTCACGGA
TAGTTGTCAATTGGTCTGAAACAAATTCGCTAGGGAATCTATTTGTGTAGAACTAATTAA
TGTAAAAAAAACAGACCATCTCGTGTTGTGTGCACTGTGATATAATGGTAGTATCAGTGC
AACTTTAATGATTGTACTTGATATTAAGTGTTCTCAACTGAGTAACTTTTAAGTGGAAAC
CAAGTTTAGATTTGGGGAGTGGTAAAGGAATCAGCTTTTTCTATTGTTAGGGGAAGACAG
TAATTTATCATTCATGGACCAGTAGATTGTTGAAAGTTGGTGAATCGGATTATAAGCTTC
TAGCTAACACAAGGATTCAGAATTAGGTAAACATCTGAAGGTTTAGTATATTAGAAACAC
CCAAACCAGTAATATGCTAACCTGATGCACTGCTGAAAGAAAATGTGAATTTTTCGTAAT
AATTGCATTTTAGTGAATTGTACAGTGGGTGGAAAGGGCATTTGGAGCTCATTAGAATGA
GACATAGTACACCCCAATGGCCCTGTTTATTAAATGTAGTGGATTAAGTGTCTGTCAACA
AATACACCAAAACCATTTTTTATAGAAACAGTATTTAATGGTCACTCAATAGCTTTCAAA
ATACATTTTTGTATTACAGCACTGCACAAGCTATTCTAATAGTGCTCTCGCCTCATCATT
CCTGCAAAGCTTGCTTTGGGGAGTTGGATAATGTGAAAATTTTAAGTACCTAGGGGAGAA
AGAGCCATGTAAATATCTGTAATAAACTTGTAGCATATGTAAAGTTTTCTTGGCCTTTAT
CTTACAAAAATGGAGTATTTTAGTATGAATTTGCTGAATGTAAGACCGTGGACTGTTTTT
TATAATATGGCCTAATTTTAAAGGTCCAAAATAACTTGTTTTTAAAGTTTGCCCTTGTGC
TAAAGTGCCAGTGTATGTATGTTATACTTGATTTGGTTGTAAACTATATTTCAAAGTAAA
CCCTAGTGTAATAAGTTTTATAACTAAAAAGGTTTAAGCTGCTAAAACTATTTTTAAGAG
ATGTGAAATGCAGTATGGGACTATCTTTTTTTCCTCCTCTAAGCCCAAAGATTAACTAGA
GTCCCTCCAACCTTATAGATTGTTGGCTTTCACAATCTTATAACCTAGGATACAGGTAGT
TTCGAGTATGGTGCCAGTGATGTTTTGTTTTTGTTTGGTCAAGGGGTAGGTGCAACCCAA
TGGACCACTTATGCAAAAGATGTAAACTCTTGCATAATACATTGATAACATGTTTTGCCA
ACTTTAAATGCTTAAACATAAGCGAAACCAGTAGCAAGTATGTGGGTCAGCTTAAAAATT
TTGATTGTTAATGCCCTATTTTCTAATTTGGCACCTCTTGATGCCTAAGCAGGTAAGCAG
ATGCCTAAGCTGTATTTCTCCAAATAAATCAAGATGAAGTACTGCCCAAGTTAAATATTG
ATAGCCTAAAGACAAGTTTATGTAGTACTTAATGTACATGATATGAATGTGAAGCATAAA
ATTAAATAAAATTTTTCCCCATTAAAAAAAAAAAAAAAAAAA
Restriction Sites Please inquire |
ACCN NM_017761
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_017761.2, NP_060231.1
RefSeq Size 2382 bp
RefSeq ORF 420 bp
Locus ID 55629
UniProt ID Q9NPJ4
Cytogenetics 1p36.11
Protein Families Druggable Genome, Transcription Factors
Summary Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_017761" in other vectors (4)
SKU Description Size Price
RC200098 PNRC2 (Myc-DDK-tagged)-Human proline-rich nuclear receptor coactivator 2 (PNRC2) 10 ug
$150.00
RC200098L3 Lenti ORF clone of Human proline-rich nuclear receptor coactivator 2 (PNRC2), Myc-DDK-tagged 10 ug
$450.00
RC200098L4 Lenti ORF clone of Human proline-rich nuclear receptor coactivator 2 (PNRC2), mGFP tagged 10 ug
$450.00
RG200098 PNRC2 (tGFP-tagged) - Human proline-rich nuclear receptor coactivator 2 (PNRC2) 10 ug
$489.00

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