BIGM103 (SLC39A8) (NM_022154) Human Untagged Clone
SKU
SC320928
SLC39A8 (untagged)-Human solute carrier family 39 (zinc transporter), member 8 (SLC39A8), transcript variant 1
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | BIGM103 |
| Synonyms | BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_022154 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_022154.5, NP_071437.3 |
| RefSeq Size | 3309 bp |
| RefSeq ORF | 1383 bp |
| Locus ID | 64116 |
| UniProt ID | Q9C0K1 |
| Cytogenetics | 4q24 |
| Domains | Zip |
| Protein Families | Transmembrane |
| Summary | This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. provided by RefSeq, Oct 2008 Transcript Variant: This variant (1) encodes the longest isoform (a). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_022154" in other vectors (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC204200 | SLC39A8 (Myc-DDK-tagged)-Human solute carrier family 39 (zinc transporter), member 8 (SLC39A8), transcript variant 1 | 10 ug |
$457.00
|
|
| RC204200L1 | Lenti ORF clone of Human solute carrier family 39 (zinc transporter), member 8 (SLC39A8), transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC204200L2 | Lenti ORF clone of Human solute carrier family 39 (zinc transporter), member 8 (SLC39A8), transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RC204200L3 | Lenti ORF clone of Human solute carrier family 39 (zinc transporter), member 8 (SLC39A8), transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC204200L4 | Lenti ORF clone of Human solute carrier family 39 (zinc transporter), member 8 (SLC39A8), transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RG204200 | SLC39A8 (tGFP-tagged) - Human solute carrier family 39 (zinc transporter), member 8 (SLC39A8), transcript variant 1 | 10 ug |
$489.00
$657.00
|
|
| SC112817 | SLC39A8 (untagged)-Human solute carrier family 39 (zinc transporter), member 8 (SLC39A8), transcript variant 1 | 10 ug |
$457.00
|
|
Citations
Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells
Aydemir, Liuzzi, McClellan et al
J Leukoc Biol (2009) 86 (2), 337-48 DOI: 10.1189/jlb.1208759
Aydemir, Liuzzi, McClellan et al
J Leukoc Biol (2009) 86 (2), 337-48 DOI: 10.1189/jlb.1208759
Cited by 233
AI Summary: OriGene products, specifically ZIP8 cDNA (RC206307) and ZIP8 siRNA (SR303597), were used in this study to overexpress and knock down ZIP8 in human T cells, respectively, enabling the authors to demonstrate ZIP8’s role in regulating IFN-gamma expression and T cell activation in response to zinc.
The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia
Besecker, Bao, Bohacova et al
Am J Physiol Lung Cell Mol Physiol (2008) 294 (6), L1127-36 DOI: 10.1152/ajplung.00057.2008
Besecker, Bao, Bohacova et al
Am J Physiol Lung Cell Mol Physiol (2008) 294 (6), L1127-36 DOI: 10.1152/ajplung.00057.2008
Cited by 154
AI Summary: In this study, OriGene’s SLC39A8 (Zip8) siRNA (SR304502) was used to inhibit Zip8 expression, allowing the authors to demonstrate that reduced Zip8 impairs zinc-mediated cytoprotection in lung epithelial cells during inflammation.
Showing 1-2 of 2 papers.
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