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KSR2 (NM_173598) Human Untagged Clone

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SKU
SC318393
KSR2 (untagged)-Human kinase suppressor of ras 2 (KSR2)
  $844.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol KSR2
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_173598 edited
ACAGTTGGTACCGCCACCATGATAGACTTGAGCATCTCCAACCTGGAAGGGCTTAGGACC
AAATGTGCTACCTCCAACGACCTCACACAAAAAGAAATCCGGACCCTGGAGAGCAAGCTG
GTGAAGTACTTCAGCCGGCAGCTGTCCTGCAAAAAGAAGGTAGCCTTGCAGGAGCGCAAC
GCGGAGCTGGACGGCTTCCCCCAGCTACGGCACTGGTTCCGAATCGTCGATGTGCGCAAG
GAGGTCCTGGAGGAAATCTCCCCCGGCCAGCTGAGCCTGGAGGACCTCTTGGAGATGACG
GATGAACAGGTGTGCGAGACTGTGGAGAAATACGGAGCCAACCGGGAGGAGTGTGCCCGC
CTCAACGCCTCCCTCTCCTGCCTCAGGAATGTCCACATGTCAGGAGGCAACCTTTCCAAA
CAAGACTGGACCATCCAGTGGCCCACCACAGAGACGGGGAAGGAGAACAATCCCGTGTGC
CCCCCGGAGCCCACCCCGTGGATCCGCACCCATCTCTCCCAGAGCCCCAGGGTCCCGTCC
AAGTGCGTCCAGCACTATTGTCACACCAGCCCCACTCCCGGGGCCCCTGTGTACACCCAC
GTGGACAGGCTTACCGTGGACGCCTACCCGGGCTTGTGCCCGCCCCCGCCACTGGAGTCG
GGCCACCGTTCCCTGCCCCCATCGCCCCGGCAGCGGCACGCGGTCCGCACCCCGCCGCGC
ACCCCCAACATCGTCACCACCGTGACCCCGCCGGGCACGCCGCCCATGAGGAAGAAGAAC
AAGCTGAAGCCCCCGGGGACCCCACCGCCCTCCTCCCGAAAACTGATACACTTGATCCCG
GGATTCACCGCGCTGCATCGGAGCAAATCCCACGAGTTCCAGCTGGGGCACCGCGTGGAC
GAGGCCCACACGCCCAAAGCCAAGAAGAAGAGCAAACCCTTGAACCTCAAGATCCACAGC
AGCGTAGGCAGCTGCGAGAACATCCCCTCTCAGCAGCGCTCCCCGCTGCTGTCCGAGCGC
TCCCTCCGCTCCTTCTTTGTGGGACACGCACCTTTCCTGCCTTCCACCCCTCCTGTTCAC
ACTGAGGCCAACTTCTCTGCAAACACACTGTCAGTGCCACGCTGGTCCCCGCAGATCCCT
CGCAGAGATCTTGGCAACTCCATCAAGCACAGGTTTTCCACCAAGTACTGGATGTCTCAG
ACGTGCACAGTCTGTGGGAAAGGGATGCTTTTTGGCCTCAAGTGTAAAAACTGCAAGTTA
AAGTGCCACAACAAATGCACCAAAGAAGCCCCACCCTGTCATCTTCTGATCATCCACCGA
GGAGATCCAGCAAGGTTAGTCCGGACAGAGTCCGTTCCGTGTGACATCAACAACCCTCTA
CGGAAGCCACCTCGCTATTCAGACCTGCACATCAGTCAGACGCTCCCCAAAACCAACAAA
ATCAACAAGGACCACATCCCTGTCCCTTACCAGCCAGACTCCAGCAGCAACCCCTCCTCC
ACGACGTCCTCCACGCCCTCCTCGCCAGCACCCCCCCTCCCTCCTAGTGCCACGCCGCCT
TCTCCCCTACACCCTTCCCCACAGTGCACACGGCAGCAGAAGAACTTCAACCTGCCAGCA
TCCCACTACTACAAATACAAGCAGCAGTTCATCTTCCCAGATGTGGTGCCGGTGCCGGAG
ACGCCGACCCGGGCGCCCCAGGTCATCCTGCATCCGGTGACCTCGAATCCAATCTTGGAA
GGAAATCCATTACTTCAAATTGAAGTGGAGCCAACGTCGGAGAATGAAGAGGTCCATGAT
GAGGCCGAAGAGTCAGAGGATGACTTCGAGGAGATGAACCTGTCCCTCCTCTCGGCCCGG
AGCTTCCCACGCAAGGCCAGCCAGACCAGCATCTTCCTTCAGGAGTGGGACATCCCCTTT
GAGCAGCTGGAGATCGGCGAGCTCATTGGAAAGGGCCGCTTTGGGCAAGTGTACCACGGC
CGCTGGCATGGCGAGGTGGCCATCCGGCTGATTGACATTGAGAGGGACAACGAGGACCAG
CTCAAGGCCTTCAAGCGGGAGGTGATGGCCTACAGGCAGACACGGCATGAGAACGTGGTG
CTTTTCATGGGTGCCTGCATGAGCCCGCCTCACCTGGCCATCATCACCAGCCTCTGTAAG
GGACGGACGCTCTATTCCGTTGTGAGGGATGCCAAAATCGTTTTGGATGTCAACAAAACC
AGGCAGATTGCTCAAGAAATTGTGAAGGGCATGGGCTACCTCCACGCCAAGGGAATCCTA
CACAAGGACCTCAAGTCAAAGAACGTCTTCTATGACAACGGCAAAGTGGTCATCACGGAC
TTTGGACTCTTCAGCATTTCTGGGGTGCTGCAGGCTGGCAGGCGGGAGGACAAACTGCGC
ATCCAGAATGGCTGGCTATGCCACCTGGCACCAGAGATCATCCGCCAGCTGTCCCCCGAC
ACAGAGGAGGATAAGCTCCCCTTCTCCAAGCACTCTGACGTCTTTGCCCTTGGCACAATC
TGGTATGAACTCCACGCCAGGGAATGGCCTTTCAAGACCCAACCAGCAGAGGCAATAATC
TGGCAAATGGGCACAGGCATGAAACCCAACCTCAGCCAGATTGGCATGGGAAAAGAAATC
TCGGACATTCTTCTCTTCTGCTGGGCCTTTGAACAAGAAGAGAGACCTACCTTCACCAAG
CTCATGGACATGCTGGAGAAACTGCCAAAGCGAAACCGTCGCCTGTCTCACCCTGGACAT
TTCTGGAAGTCTGCAGAGCTGTGAGGTTTGTCAAGGGC
Restriction Sites Please inquire |
ACCN NM_173598
Insert Size 2800 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_173598.4, NP_775869.3
RefSeq Size 17008 bp
RefSeq ORF 2766 bp
Locus ID 283455
UniProt ID Q6VAB6
Cytogenetics 12q24.22-q24.23
Protein Families Druggable Genome, Protein Kinase
Summary Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_173598" in other vectors (7)
SKU Description Size Price
RC211665 KSR2 (Myc-DDK-tagged)-Human kinase suppressor of ras 2 (KSR2) 10 ug
$843.00
RC211665L1 Lenti ORF clone of Human kinase suppressor of ras 2 (KSR2), Myc-DDK-tagged 10 ug
$1,143.00
RC211665L2 Lenti ORF clone of Human kinase suppressor of ras 2 (KSR2), mGFP tagged 10 ug
$1,143.00
RC211665L3 Lenti ORF clone of Human kinase suppressor of ras 2 (KSR2), Myc-DDK-tagged 10 ug
$1,143.00
RC211665L4 Lenti ORF clone of Human kinase suppressor of ras 2 (KSR2), mGFP tagged 10 ug
$1,143.00
RG211665 KSR2 (tGFP-tagged) - Human kinase suppressor of ras 2 (KSR2) 10 ug
$789.00 $1,043.00
SC306873 KSR2 (untagged)-Human kinase suppressor of ras 2 (KSR2) 10 ug
$928.00

file-alt Citations

KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation
Pearce, Atanassova, Banton et al
Cell (2013) 155 (4), 765-77 DOI: 10.1016/j.cell.2013.09.058
Cited by 204
AI Summary: OriGene products, specifically the KSR2 Myc-DDK-tagged cDNA (RC211421) and KSR2 shRNA plasmids (TG314367), were used in this study to express and knockdown KSR2 in cell lines, enabling the authors to assess the functional impact of KSR2 mutations on cellular signaling and metabolism.
FigureFigureFigure
KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation
Pearce, Atanassova, Banton et al
Cell (2013) 155, 1-13
AI Summary: OriGene contributed to the study by providing the human KSR2 cDNA clone (product SC318393), which was used to investigate the role of KSR2 mutations in obesity and metabolic dysfunction.
Snippet: A human cDNA clone encoding the 921 amino acid isoform of KSR2 (ENSEMBL transcript ID: ENST00000425217) was obtained from Origene (SC318393)
Showing 1-2 of 2 papers.
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