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PAN3 (NM_175854) Human Untagged Clone

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SKU
SC314436
PAN3 (untagged)-Human PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) (PAN3)
  $894.00
3 Weeks*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol PAN3
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>SC314436 representing NM_175854.
Blue=Insert sequence Red=Cloning site Green=Tag(s)

GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG
GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC
ATGAACAGTGGCGGCGGCCTCCCGCCCCCCTCGGCCGCCGCCTCCCCTTCCTCCTCCTCGCTGGCGGCG
GCGGTGGCGGTGGTGGCCCCGCCGGGGGTCGGGGGTGTCCCCGGCGGGGCGGCGGTAGGAGTGAAGCTG
AAGTACTGCCGCTACTACGCTAAGGATAAGACTTGCTTCTACGGGGAGGAGTGTCAGTTCCTGCATGAG
GACCCTGCCGCCGGGGCTGCCCCGGGCCTCGGCCTCCATAGCAACAGCGTCCCCCTGGCTCTGGCTGGT
GCACCCGTGGCCGGCTTTCCGCCGGGAGCCGTCGCGGGCGGGGGAGCTGGGCCGCCCCCCGGGCCCAAG
AAGCCGGACCTGGGGGACCCGGGGACCGGAGCCGCAGCCGGCGGAGGAGGCAGTAGCGGGGGACTCGAT
GGACCGCGGCTGGCAATTCCAGGAATGGATGGAGGTGCTTTAACTGATACAAGTCTCACAGATTCCTAT
TTTAGCACCAGCTTTATTGGAGTCAATGGATTTGGAAGCCCTGTAGAAACAAAATATCCCCTGATGCAG
AGAATGACTAATAGTAGCAGCTCCCCAAGCCTTCTAAATGACAGTGCCAAGCCATATTCAGCCCATGAT
CCTCTAACATCACCTGCTTCATCCTTGTTTAATGACTTTGGTGCCCTCAACATCTCTCAGAGACGAAAG
CCAAGGAAGTATCGCCTGGGGATGCTGGAGGAGAGGCTAGTTCCGATGGGATCAAAGGCACGAAAAGCA
AAGAACCCTATTGGCTGCCTTGCTGACAGGTGTAAATCAGGAGTACCCATCAATATGGTTTGGTGGAAC
AGAGTCACAGAAAACAATTTACAGACACCAAATCCTACTGCAAGCGAGTTTATTCCTAAAGGAGGATCA
ACCTCCAGGCTGAGTAACGTGTCCCAGTCAAATATGTCTGCCTTCTCTCAAGTTTTCTCTCACCCATCC
ATGGGAAGCCCTGCTACTGCTGGATTAGCGCCAGGAATGTCGTTGTCTGCTGGGTCTTCCCCTCTTCAT
TCCCCCAAGATTACTCCACATACTTCTCCTGCTCCCAGAAGAAGAAGTCACACTCCAAATCCAGCAAGT
TACATGGTGCCTTCTAGTGCCTCTACATCTGTTAATAATCCTGTTTCTCAGACTCCGTCTTCTGGTCAG
GTGATCCAAAAGGAAACTGTTGGTGGGACGACTTACTTCTATACAGACACAACTCCAGCACCTTTGACT
GGAATGGTGTTTCCAAACTATCATATTTATCCTCCAACTGCACCTCACGTTGCTTATATGCAACCGAAA
GCAAACGCACCTTCCTTCTTCATGGCTGATGAACTCCGACAGGAGCTGATCAACAGACATTTAATAACA
ATGGCTCAAATTGATCAAGCAGATATGCCAGCAGTTCCTACAGAGGTTGACAGCTACCATAGCCTATTC
CCTCTAGAACCACTGCCACCTCCCAACCGGATACAGAAATCAAGTAATTTTGGATATATTACATCTTGC
TACAAAGCTGTAAACAGCAAAGATGATCTGCCATATTGCCTTCGGAGGATACATGGTTTTCGTCTTGTT
AACACAAAGTGCATGGTGTTGGTCGACATGTGGAAGAAAATTCAACACTCAAATATCGTAACTTTGCGT
GAAGTATTTACCACTAAAGCATTTGCTGAGCCCTCTCTTGTGTTTGCATATGATTTCCATGCTGGAGGA
GAAACTATGATGAGCAGACACTTTAATGACCCTAATGCTGATGCCTACTTCACCAAGAGAAAGTGGGGT
CAGCACGAGGGACCATTGCCCAGGCAGCATGCTGGATTATTGCCAGAATCTCTTATTTGGGCATATATT
GTCCAACTAAGTTCTGCATTGCGTACCATTCATACAGCAGGTTTGGCATGTCGAGTTATGGATCCAACA
AAGATTCTGATAACTGGCAAAACAAGGTTGCGAGTAAATTGTGTTGGAGTTTTTGATGTTTTAACATTT
GATAACAGTCAAAATAATAATCCATTGGCATTAATGGCCCAGTACCAGCAAGCAGATCTGATATCATTA
GGAAAAGTTGTGTTGGCTTTGGCTTGCAACTCTTTGGCAGGAATTCAGCGAGAGAATTTACAGAAAGCC
ATGGAACTGGTGACAATCAACTATTCCTCTGACCTGAAGAATCTGATTTTGTATTTGTTGACTGACCAA
AACAGGATGCGAAGTGTAAATGACATCATGCCCATGATTGGTGCTCGATTTTATACTCAATTGGATGCT
GCTCAAATGAGAAATGATGTCATAGAGGAAGACCTTGCAAAGGAGGTTCAAAATGGAAGACTGTTTAGG
CTCCTAGCAAAATTGGGAACAATCAATGAGAGGCCGGAGTTTCAGAAGGATCCCACTTGGTCAGAGACT
GGAGACCGTTATCTGTTGAAACTCTTTAGGGATCATCTTTTTCATCAGGTGACAGAAGCAGGTGCTCCC
TGGATTGACCTCAGTCATATAATTTCTTGTCTTAACAAGCTAGATGCTGGTGTGCCAGAAAAAATAAGC
CTGATTTCCAGAGATGAGAAGAGTGTACTTGTGGTGACCTACAGTGACTTAAAGCGCTGCTTTGAAAAT
ACTTTTCAAGAACTGATTGCAGCTGCAAATGGTCAGTTGTAG
ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT
TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC
Restriction Sites SgfI-MluI |
ACCN NM_175854
Insert Size 2664 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_175854.7
RefSeq Size 5643 bp
RefSeq ORF 2664 bp
Locus ID 255967
UniProt ID Q58A45
Cytogenetics 13q12.2
Protein Families Druggable Genome
MW 95.6 kDa
Summary Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_175854" in other vectors (4)
SKU Description Size Price
RC218027 PAN3 (Myc-DDK-tagged)-Human PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) (PAN3) 10 ug
$589.00 $629.00
RC218027L3 Lenti ORF clone of Human PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) (PAN3), Myc-DDK-tagged 10 ug
$929.00
RC218027L4 Lenti ORF clone of Human PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) (PAN3), mGFP tagged 10 ug
$929.00
RG218027 PAN3 (tGFP-tagged) - Human PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) (PAN3) 10 ug
$829.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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