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AP2 alpha (TFAP2A) (NM_001042425) Human Untagged Clone

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SKU
SC311273
TFAP2A (untagged)-Human transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 3
  $503.00
3 Weeks*
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Other products for "AP2 alpha or NM_001042425"

Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol AP2 alpha
Synonyms AP-2; AP-2alpha; AP2TF; BOFS; TFAP2
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Restriction Sites SgfI-RsrII |
ACCN NM_001042425
Insert Size 1302 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001042425.1
RefSeq Size 3150 bp
RefSeq ORF 1302 bp
Locus ID 7020
UniProt ID P05549
Cytogenetics 6p24.3
Protein Families Druggable Genome, Transcription Factors
MW 47.4 kDa
Summary The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.provided by RefSeq, Dec 2009
Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
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Documents
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"NM_001042425" in other vectors (4)
SKU Description Size Price
RC220080 TFAP2A (Myc-DDK-tagged)-Human transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 3 10 ug
$686.00
RC220080L3 Lenti-ORF clone of TFAP2A (Myc-DDK-tagged)-Human transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 3 10 ug
$986.00
RC220080L4 Lenti-ORF clone of TFAP2A (mGFP-tagged)-Human transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 3 10 ug
$986.00
RG220080 TFAP2A (tGFP-tagged) - Human transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 3 10 ug
$886.00

file-alt Citations

The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes
Wells, Rivera, Kim et al
Mol Cancer Res (2010) 8 (7), 975-85 DOI: 10.1158/1541-7786.MCR-10-0033
AI Summary: In this study, OriGene’s pCMV6-WT1(+KTS) expression plasmid was used to conditionally express the predominant WT1 isoform (+KTS) in cells, enabling the identification of Scribble as a direct transcriptional target in renal podocytes.
FigureFigure
Showing 1-1 of 1 papers.
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