ErbB 4 (ERBB4) (NM_005235) Human Untagged Clone
SKU
SC309924
ERBB4 (untagged)-Human v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), transcript variant JM-a/CVT-1
$1,139.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | ErbB 4 |
| Synonyms | ALS19; HER4; p180erbB4 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_005235 |
| Insert Size | 6700 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | It is not a varient. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_005235.1, NP_005226.1 |
| RefSeq Size | 11941 bp |
| RefSeq ORF | 3927 bp |
| Locus ID | 2066 |
| UniProt ID | Q15303 |
| Cytogenetics | 2q34 |
| Domains | FU, Furin-like, pkinase, Recep_L_domain, S_TKc, TyrKc, YLP |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Endocytosis, ErbB signaling pathway |
| Summary | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. provided by RefSeq, Jul 2008 Transcript Variant: This variant (JM-a/CYT-1) represents the longer transcript and encodes the longer isoform (JM-a/CYT-1). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_005235" in other vectors (8)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC220449 | ERBB4 (Myc-DDK-tagged)-Human v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), transcript variant JM-a/CVT-1 | 10 ug |
$1,138.00
|
|
| RC220449L1 | Lenti ORF clone of Human v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), transcript variant JM-a/CVT-1, Myc-DDK-tagged | 10 ug |
$1,438.00
|
|
| RC220449L2 | Lenti ORF clone of Human v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), transcript variant JM-a/CVT-1, mGFP tagged | 10 ug |
$1,438.00
|
|
| RC220449L3 | Lenti ORF clone of Human v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), transcript variant JM-a/CVT-1, Myc-DDK-tagged | 10 ug |
$1,438.00
|
|
| RC220449L4 | Lenti ORF clone of Human v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), transcript variant JM-a/CVT-1, mGFP tagged | 10 ug |
$1,438.00
|
|
| RC600008 | ERBB4 (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), Signal peptide (1-25) plus EC domain (26-651) | 10 ug |
$289.00
$606.00
|
|
| RG220449 | ERBB4 (tGFP-tagged) - Human v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), transcript variant JM-a/CVT-1 | 10 ug |
$789.00
$1,338.00
|
|
| SC323669 | ERBB4 (untagged)-Kinase deficient mutant (K751M) of Human v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), transcript variant JM-a/CVT-1 | 10 ug |
$1,139.00
|
|
Citations
Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma
Marks, Gong, Chitale et al
Cancer Res (2008) 68 (14), 5524-8 DOI: 10.1158/0008-5472.CAN-08-0099
Marks, Gong, Chitale et al
Cancer Res (2008) 68 (14), 5524-8 DOI: 10.1158/0008-5472.CAN-08-0099
AI Summary: In this study, OriGene's MEK1 (MAP2K1) cDNA clones were used to express both wild-type and mutant MEK1 proteins, enabling functional analysis of the novel MEK1 mutations identified in lung adenocarcinoma.
Showing 1-1 of 1 papers.
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