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UNC45B (NM_173167) Human Untagged Clone

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SKU
SC306792
UNC45B (untagged)-Human unc-45 homolog B (C. elegans) (UNC45B), transcript variant 1
  $853.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol UNC45B
Synonyms CMYA4; CTRCT43; MFM11; SMUNC45; UNC-45B; UNC45
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF sequence for NM_173167 edited
ATGGCAGAGGTGGAAGCGGTACAGCTGAAGGAGGAAGGAAACCGGCATTTCCAGCTCCAG
GACTACAAGGCCGCCACAAATAGCTACAGCCAGGCCCTGAAGCTGACCAAGGACAAGGCC
CTGCTGGCCACGCTTTATCGGAACCGGGCAGCCTGTGGCCTGAAAACGGAGAGCTACATC
CAGGCAGCTTCAGATGCCTCCAGAGCCATCGACATCAACTCCTCGGACATCAAGGCTCTG
TATCGGCGATGCCAGGCACTGGAGCACCTGGGGAAGCTGGACCAGGCCTTCAAAGACGTG
CAGCGTTGTGCCACCCTCGAGCCACGGAACCAGAACTTCCAGGAGATGCTGAGGAGACTC
AACACCAGCATTCAGGAGAAGCTCCGAGTGCAGTTCTCCACAGACTCGAGGGTACAGAAG
ATGTTTGAGATCCTCTTGGATGAAAACAGTGAGGCTGATAAGCGGGAAAAGGCTGCCAAC
AATCTCATTGTCCTAGGCCGTGAGGAAGCAGGGGCTGAGAAGATCTTCCAGAACAATGGA
GTAGCCTTGCTACTGCAGCTTCTGGACACTAAGAAGCCTGAGCTGGTGCTGGCTGCAGTG
CGGACCCTGTCGGGCATGTGCAGCGGCCACCAAGCCAGAGCCACAGTGATTCTGCATGCA
GTGCGGATAGACCGAATCTGTAGCCTCATGGCCGTGGAGAATGAGGAGATGTCTCTGGCT
GTCTGCAACCTGCTCCAAGCCATCATTGACTCCTTGTCTGGGGAGGACAAGCGGGAGCAT
CGAGGGAAGGAGGAGGCCCTGGTTCTAGACACCAAGAAGGACCTGAAGCAGATCACCAGC
CACCTGCTGGACATGCTAGTCAGCAAGAAGGTGTCTGGCCAGGGCAGGGATCAGGCGCTG
AACCTGCTCAATAAGAATGTTCCCAGGAAGGACCTTGCCATTCATGACAACTCACGTACC
ATCTATGTGGTGGATAATGGTCTGAGGAAGATCCTGAAGGTTGTGGGGCAGGTTCCAGAT
CTGCCATCCTGCCTGCCCCTGACTGACAACACCCGCATGCTGGCCTCTATCCTCATCAAC
AAGCTCTATGATGACCTGCGCTGTGACCCGGAGCGCGATCACTTCCGCAAGATCTGTGAG
GAATATATCACGGGCAAGTTTGACCCCCAGGACATGGACAAGAACTTGAATGCCATCCAG
ACAGTGTCAGGGATCCTGCAGGGCCCCTTTGACCTGGGCAACCAGCTGCTGGGACTGAAA
GGTGTGATGGAGATGATGGTGGCACTATGTGGCTCAGAGCGCGAGACGGACCAGCTGGTG
GCCGTGGAGGCCCTCATCCATGCCTCCACGAAGCTCAGCCGCGCCACCTTCATCATCACC
AATGGAGTGTCACTGCTCAAACAGATCTACAAGACCACCAAAAATGAGAAGATCAAGATC
CGCACACTGGTGGGACTCTGTAAGCTCGGCTCTGCAGGTGGCACAGACTACGGTCTCAGG
CAGTTTGCGGAAGGGTCGACAGAAAAACTGGCCAAACAGTGTCGCAAGTGGCTGTGCAAT
ATGTCCATAGACACTCGGACCCGACGCTGGGCAGTGGAGGGCCTGGCCTACCTCACGCTG
GACGCTGATGTGAAGGACGACTTTGTCCAGGACGTCCCTGCCCTGCAGGCCATGTTTGAG
CTGGCCAAG::::::ACCAGTGACAAGACCATCCTGTACTCGGTGGCCACCACCCTGGTG
AACTGCACCAACAGCTACGATGTCAAGGAGGTCATCCCAGAGCTTGTCCAGCTCGCCAAG
TTCTCCAAGCAGCATGTGCCCGAGGAACACCCCAAGGACAAGAAGGACTTTATAGACATG
CGGGTGAAGCGGCTTCTGAAGGCGGGTGTCATCTCTGCCCTGGCTTGCATGGTGAAAGCA
GATAGTGCCATCCTCACTGACCAGACCAAGGAGCTGCTGGCCAGGGTATTCCTGGCACTG
TGTGACAACCCAAAGGACCGAGGCACCATTGTGGCTCAAGGTGGTGGCAAGGCCCTGATT
CCCCTGGCTTTGGAGGGCACAGATGTGGGCAAGGTGAAGGCAGCCCACGCTCTAGCAAAG
ATCGCTGCTGTCTCCAATCCGGACATTGCTTTTCCTGGGGAGCGGGTGTATGAGGTGGTG
CGGCCCCTTGTAAGACTCTTGGACACACAGAGGGATGGGCTTCAGAACTATGAGGCTCTC
CTAGGCCTCACCAACCTGTCTGGGCGGAGTGACAAACTCCGGCAGAAGATCTTTAAGGAG
AGGGCCTTGCCAGACATCGAGAACTACATGTTTGAGAATCATGATCAGCTGCGGCAGGCG
GCCACCGAGTGCATGTGCAACATGGTGCTCCACAAGGAGGTACAGGAAAGGTTCTTGGCT
GACGGGAATGACCGGCTGAAGCTGGTGGTGCTGCTCTGCGGGGAGGATGATGATAAGGTG
CAGAATGCGGCTGCAGGGGCTCTGGCCATGCTGACAGCAGCACACAAGAAACTGTGCCTC
AAGATGACTCAAGTGACAACCCAGTGGTTGGAGATCCTCCAGCGGCTTTGCCTGCACGAC
CAGCTGTCTGTCCAACACCGGGGCCTGGTCATTGCCTACAACCTACTGGCAGCCGATGCT
GAGCTGGCCAAGAAGCTGGTGGAGAGTGAGCTGCTGGAGATCCTGACTGTGGTGGGCAAA
CAGGAGCCAGATGAGAAGAAGGCAGAAGTGGTTCAGACAGCCCGAGAATGTCTCATCAAG
TGCATGGATTATGGTTTCATTAAACCAGTGTCTTAG
Restriction Sites Please inquire |
ACCN NM_173167
Insert Size 2800 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The open reading frame of this TrueClone was fully sequenced and found to differ from the protein associated to this reference by three amino acids.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_173167.2, NP_775259.1
RefSeq Size 5694 bp
RefSeq ORF 2796 bp
Locus ID 146862
UniProt ID Q8IWX7
Cytogenetics 17q12
Summary This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. provided by RefSeq, Apr 2015
Transcript Variant: This variant (1) encodes the longest isoform (1).
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Documents
Resources
"NM_173167" in other vectors (4)
SKU Description Size Price
RC223751 UNC45B (Myc-DDK-tagged)-Human unc-45 homolog B (C. elegans) (UNC45B), transcript variant 1 10 ug
$300.00
RC223751L3 Lenti ORF clone of Human unc-45 homolog B (C. elegans) (UNC45B), transcript variant 1, Myc-DDK-tagged 10 ug
$600.00
RC223751L4 Lenti ORF clone of Human unc-45 homolog B (C. elegans) (UNC45B), transcript variant 1, mGFP tagged 10 ug
$600.00
RG223751 UNC45B (tGFP-tagged) - Human unc-45 homolog B (C. elegans) (UNC45B), transcript variant 1 10 ug
$789.00

file-alt Citations

The myosin chaperone UNC45B is involved in lens development and autosomal dominant juvenile cataract
Hansen, Comyn, Mang et al
Eur. J. Hum. Genet. (2014)
Cited by 41
AI Summary: OriGene’s UNC45B cDNA clone (NM_001033576; SC306792) was used as the template for site-directed mutagenesis to study the effects of the identified mutation on lens development in this research.
Snippet: were analyzed using standard protocols. The UNC45B cDNA clone NM_001033576 purchased from Origene (SC306792, Origene, Rockville, MD, USA) was used for site-directed mutagenesis. Total RNA was isolated from ... Cite SaveSaving
Showing 1-1 of 1 papers.
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