POLE (NM_006231) Human Untagged Clone
$2,076.00
3 Weeks*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | POLE |
| Synonyms | CRCS12; FILS; IMAGEI; POLE1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | SgfI-RsrII | |
| ACCN | NM_006231 |
| Insert Size | 6861 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_006231.3 |
| RefSeq Size | 8024 bp |
| RefSeq ORF | 6861 bp |
| Locus ID | 5426 |
| UniProt ID | Q07864 |
| Cytogenetics | 12q24.33 |
| Protein Families | Druggable Genome |
| Protein Pathways | Base excision repair, DNA replication, Metabolic pathways, Nucleotide excision repair, Purine metabolism, Pyrimidine metabolism |
| MW | 261.5 kDa |
| Summary | This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. provided by RefSeq, Sep 2013 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_006231" in other vectors (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC224742 | POLE (Myc-DDK-tagged)-Human polymerase (DNA directed), epsilon (POLE) | 10 ug |
$1,886.00
|
|
| RC224742L1 | Lenti ORF clone of Human polymerase (DNA directed), epsilon (POLE), Myc-DDK-tagged | 10 ug |
$2,186.00
|
|
| RG224742 | POLE (tGFP-tagged) - Human polymerase (DNA directed), epsilon (POLE) | 10 ug |
$2,286.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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