TRPM2 (NM_003307) Human Untagged Clone
SKU
SC303292
TRPM2 (untagged)-Human transient receptor potential cation channel, subfamily M, member 2 (TRPM2), transcript variant 1
$1,286.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | TRPM2 |
| Synonyms | EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H; NUDT9L1; TRPC7 |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | SgfI-MluI | |
| ACCN | NM_003307 |
| Insert Size | 5624 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | There is 1 nucleotide difference between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substituion of 1 aa. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_003307.3 |
| RefSeq Size | 5876 bp |
| RefSeq ORF | 5624 bp |
| Locus ID | 7226 |
| UniProt ID | O94759 |
| Cytogenetics | 21q22.3 |
| Protein Families | Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane |
| MW | 210.7 kDa |
| Summary | The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. provided by RefSeq, Feb 2016 Transcript Variant: This variant (1) encodes isoform 1. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_003307" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC216220 | TRPM2 (Myc-DDK-tagged)-Human transient receptor potential cation channel, subfamily M, member 2 (TRPM2), transcript variant 1 | 10 ug |
$1,286.00
|
|
| RC216220L3 | Lenti-ORF clone of TRPM2 (Myc-DDK-tagged)-Human transient receptor potential cation channel, subfamily M, member 2 (TRPM2), transcript variant 1 | 10 ug |
$1,586.00
|
|
| RC216220L4 | Lenti-ORF clone of TRPM2 (mGFP-tagged)-Human transient receptor potential cation channel, subfamily M, member 2 (TRPM2), transcript variant 1 | 10 ug |
$1,586.00
|
|
| RG216220 | TRPM2 (tGFP-tagged) - Human transient receptor potential cation channel, subfamily M, member 2 (TRPM2), transcript variant 1 | 10 ug |
$789.00
$1,486.00
|
|
Citations
Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate
Csanády, Törocsik
J Gen Physiol (2009) 133 (2), 189-203 DOI: 10.1085/jgp.200810109
Csanády, Törocsik
J Gen Physiol (2009) 133 (2), 189-203 DOI: 10.1085/jgp.200810109
Cited by 103
AI Summary: In this paper, OriGene’s human TRPM2 cDNA (OriGene, SC118291) was used to express the TRPM2 channel in Xenopus oocytes, enabling the functional studies that elucidated the Ca2+ activation mechanism of TRPM2.
Showing 1-1 of 1 papers.
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