FOXM1 (NM_202003) Human Untagged Clone
$1,029.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | FOXM1 |
| Synonyms | FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11; HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29; TRIDENT |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_202003 |
| Insert Size | 3400 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_202003.1, NP_973732.1 |
| RefSeq Size | 3487 bp |
| RefSeq ORF | 2247 bp |
| Locus ID | 2305 |
| UniProt ID | Q08050 |
| Cytogenetics | 12p13.33 |
| Protein Families | Transcription Factors |
| Summary | The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2011 Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_202003" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC202540 | FOXM1 (Myc-DDK-tagged)-Human forkhead box M1 (FOXM1), transcript variant 3 | 10 ug |
$1,027.00
|
|
| RC202540L1 | Lenti ORF clone of Human forkhead box M1 (FOXM1), transcript variant 3, Myc-DDK-tagged | 10 ug |
$1,327.00
|
|
| RC202540L2 | Lenti ORF clone of Human forkhead box M1 (FOXM1), transcript variant 3, mGFP tagged | 10 ug |
$1,327.00
|
|
| RC202540L3 | Lenti ORF clone of Human forkhead box M1 (FOXM1), transcript variant 3, Myc-DDK-tagged | 10 ug |
$1,327.00
|
|
| RC202540L4 | Lenti ORF clone of Human forkhead box M1 (FOXM1), transcript variant 3, mGFP tagged | 10 ug |
$1,327.00
|
|
| RG202540 | FOXM1 (tGFP-tagged) - Human forkhead box M1 (FOXM1), transcript variant 3 | 10 ug |
$1,227.00
|
|
Citations
The conformation of FOXM1 homodimers in vivo is crucial for regulating transcriptional activities
Hsu, Yao, Chen et al
Nucleic Acids Res (2024)
Hsu, Yao, Chen et al
Nucleic Acids Res (2024)
Cited by 8
O-GlcNAc transferase regulates p21 protein levels and cell proliferation through the FoxM1-Skp2 axis in a p53-independent manner
de Queiroz, Moon, Prives
J Biol Chem (2022) 298 (9), 102289 DOI: 10.1016/j.jbc.2022.102289
de Queiroz, Moon, Prives
J Biol Chem (2022) 298 (9), 102289 DOI: 10.1016/j.jbc.2022.102289
Cited by 23
AI Summary: In this study, OriGene’s OGT siRNA (SR304155) and OGT shRNA (TG311024) were used to reduce O-GlcNAc transferase levels, enabling the authors to demonstrate that OGT inhibition increases p21 expression and impairs cancer cell proliferation via the FoxM1-Skp2 axis.
Snippet: deletion of OGT leads to embryo lethality in flies, zebrafish, and mice (19, 20). Glycosylation, including O-GlcNAcylation, is aberrant in cancer cells and this can contribute in different ways to tumorigenesis (17, 21). Modulation of both OGT and OGA can stabilize p53 and activate the p53 pathway in tumor cells (22, 23). Among the effects of O-GlcNAc modulation are increased levels of p21. Since
Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression
Barger, Zhang, Hillman et al
Oncotarget (2015) 6 (29), 27613-27 DOI: 10.18632/oncotarget.4546
Barger, Zhang, Hillman et al
Oncotarget (2015) 6 (29), 27613-27 DOI: 10.18632/oncotarget.4546
Cited by 93
AI Summary: In this study, OriGene products—specifically the FOXM1 cDNA clone (RC208447) and FOXM1 shRNA (TL312204)—were used to manipulate FOXM1 expression in ovarian cancer cell models, enabling the authors to investigate FOXM1’s role in cell cycle progression and its genetic regulation in epithelial ovarian cancer.
Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy
Uddin, Ahmed, Hussain et al
Am. J. Pathol. (2011) 178 (2), 537-47 DOI: 10.1016/j.ajpath.2010.10.020
Uddin, Ahmed, Hussain et al
Am. J. Pathol. (2011) 178 (2), 537-47 DOI: 10.1016/j.ajpath.2010.10.020
Cited by 156
AI Summary: OriGene’s pCMV6-XL5 vector (catalog no. SC128214) was used in this study for gene overexpression experiments to investigate the functional role of FOXM1 in colorectal cancer cells.
Snippet: Green indicates down-regulated expression and red indicates up-regulated expression, with intensity of color reflecting intensity of up- or down-regulation. ... SC128214) vector alone (pCMV6-XL5) was purchased from OriGene Technologies (Rockville, MD).
Down-regulation of Forkhead Box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells
Wang, Banerjee, Kong et al
Cancer Res (2007) 67 (17), 8293-300 DOI: 10.1158/0008-5472.CAN-07-1265
Wang, Banerjee, Kong et al
Cancer Res (2007) 67 (17), 8293-300 DOI: 10.1158/0008-5472.CAN-07-1265
Showing 1-5 of 5 papers.
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