STAT3 (NM_139276) Human Untagged Clone
SKU
SC124165
STAT3 (untagged)-Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1
$1,059.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | STAT3 |
| Synonyms | ADMIO; ADMIO1; APRF; HIES |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_139276 |
| Insert Size | 3384 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_139276.2, NP_644805.1 |
| RefSeq Size | 4978 bp |
| RefSeq ORF | 2313 bp |
| Locus ID | 6774 |
| UniProt ID | P40763 |
| Cytogenetics | 17q21.2 |
| Domains | SH2, STAT |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Acute myeloid leukemia, Adipocytokine signaling pathway, Chemokine signaling pathway, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer |
| Summary | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. provided by RefSeq, Aug 2020 Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_139276" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC215836 | STAT3 (Myc-DDK-tagged)-Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1 | 10 ug |
$1,057.00
|
|
| RC215836L1 | Lenti ORF clone of Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,357.00
|
|
| RC215836L2 | Lenti ORF clone of Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, mGFP tagged | 10 ug |
$1,357.00
|
|
| RC215836L3 | Lenti ORF clone of Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,357.00
|
|
| RC215836L4 | Lenti ORF clone of Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, mGFP tagged | 10 ug |
$1,357.00
|
|
| RG215836 | STAT3 (tGFP-tagged) - Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1 | 10 ug |
$1,257.00
|
|
Citations
Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis
Liu, Yan, Wang et al
Oncol Lett (2020) 20 (4), 112 DOI: 10.3892/ol.2020.11973
Liu, Yan, Wang et al
Oncol Lett (2020) 20 (4), 112 DOI: 10.3892/ol.2020.11973
Cited by 13
AI Summary: In this study, OriGene’s STAT3 overexpression plasmid (cat. no. SC124165) and OE-NC (cat. no. SC124165) were used to investigate the role of STAT3 in hydrogen gas-mediated apoptosis and autophagy in lung cancer cells.
Snippet: no. SR322490) were purchased from OriGene Technologies, Inc.. The overexpressing plasmid STAT3 (OE-STAT3, cat. no. SC124165) and OE-NC (cat. no. SC124165) were also obtained from OriGene Technologies, Inc
A Novel STAT3 Mutation in a Qatari Patient With Hyper-IgE Syndrome
Chaimowitz, Branch, Reyes et al
Front Pediatr (2019) 7, 130 DOI: 10.3389/fped.2019.00130
Chaimowitz, Branch, Reyes et al
Front Pediatr (2019) 7, 130 DOI: 10.3389/fped.2019.00130
AI Summary: OriGene's wild-type STAT3 cDNA plasmid (NM_139276) was used as the template to generate an expression plasmid containing the patient's novel STAT3 mutation for functional analysis in this study.
Snippet: An expression plasmid with the patient's mutation was generated using a plasmid containing the wild-type (WT) STAT3 complementary DNA (cDNA) (NM_139276;Origene) altered with QuikChange site-directed mutagenesis (Agilent Technologies) using the primers
STAT3-induced WDR1 overexpression promotes breast cancer cell migration
Lee, Kim, Kim et al
Cell. Signal. (2016) 28 (11), 1753-1760 DOI: 10.1016/j.cellsig.2016.08.006
Lee, Kim, Kim et al
Cell. Signal. (2016) 28 (11), 1753-1760 DOI: 10.1016/j.cellsig.2016.08.006
Cited by 31
At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells
Rozovski, Harris, Li et al
J. Immunol. (2016)
Rozovski, Harris, Li et al
J. Immunol. (2016)
Cited by 44
Modulation of vascular smooth muscle cell phenotype by STAT-1 and STAT-3
Kirchmer, Franco, Albasanz-Puig et al
Atherosclerosis (2014) 234 (1), 169-175 DOI: 10.1016/j.atherosclerosis.2014.02.029
Kirchmer, Franco, Albasanz-Puig et al
Atherosclerosis (2014) 234 (1), 169-175 DOI: 10.1016/j.atherosclerosis.2014.02.029
Cited by 30
AI Summary: In this study, OriGene’s STAT-3 cDNA was used for overexpression experiments to investigate how STAT-3 influences the phenotype of vascular smooth muscle cells.
Snippet: work [14]. For overexpression studies, STAT-1 and STAT-3 cDNAs, obtained from GeneCopoeia and Origene respectively, were subcloned into lentiviral vector, pCDH-EF1-Puro (System Biosciences). Production, concentration ... Cite SaveSaving
MafB is a downstream target of the IL-10/STAT3 signaling pathway, involved in the regulation of macrophage de-activation
Gemelli, Marani, Bicciato et al
Biochim. Biophys. Acta (2014)
Gemelli, Marani, Bicciato et al
Biochim. Biophys. Acta (2014)
Cited by 34
Showing 1-6 of 11 papers.
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