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SIRT6 (NM_016539) Human Untagged Clone

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SKU
SC123758
SIRT6 (untagged)-Human sirtuin 6 (SIRT6), transcript variant 1
  $457.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol SIRT6
Synonyms SIR2L6
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_016539 edited
AGGATGTCGGTGAATTACGCGGCGGGGCTGTCGCCGTACGCGGACAAGGGCAAGTGCGGC
CTCCCGGAGATCTTCGACCCCCCGGAGGAGCTGGAGCGGAAGGTGTGGGAACTGGCGAGG
CTGGTCTGGCAGTCTTCCAGTGTGGTGTTCCACACGGGTGCCGGCATCAGCACTGCCTCT
GGCATCCCCGACTTCAGGGGTCCCCACGGAGTCTGGACCATGGAGGAGCGAGGTCTGGCC
CCCAAGTTCGACACCACCTTTGAGAGCGCGCGGCCCACGCAGACCCACATGGCGCTGGTG
CAGCTGGAGCGCGTGGGCCTCCTCCGCTTCCTGGTCAGCCAGAACGTGGACGGGCTCCAT
GTGCGCTCAGGCTTCCCCAGGGACAAACTGGCAGAGCTCCACGGGAACATGTTTGTGGAA
GAATGTGCCAAGTGTAAGACGCAGTACGTCCGAGACACAGTCGTGGGCACCATGGGCCTG
AAGGCCACGGGCCGGCTCTGCACCGTGGCTAAGGCAAGGGGGCTGCGAGCCTGCAGGGGA
GAGCTGAGGGACACCATCCTAGACTGGGAGGACTCCCTGCCCGACCGGGACCTGGCACTC
GCCGATGAGGCCAGCAGGAACGCCGACCTGTCCATCACGCTGGGTACATCGCTGCAGATC
CGGCCCAGCGGGAACCTGCCGCTGGCTACCAAGCGCCGGGGAGGCCGCCTGGTCATCGTC
AACCTGCAGCCCACCAAGCACGACCGCCATGCTGACCTCCGCATCCATGGCTACGTTGAC
GAGGTCATGACCCGGCTCATGAAGCACCTGGGGCTGGAGATCCCCGCCTGGGACGGCCCC
CGTGTGCTGGAGAGGGCGCTGCCACCCCTGCCCCGCCCGCCCACCCCCAAGCTGGAGCCC
AAGGAGGAATCTCCCACCCGGATCAACGGCTCTATCCCCGCCGGCCCCAAGCAGGAGCCC
TGCGCCCAGCACAACGGCTCAGAGCCCGCCAGCCCCAAACGGGAGCGGCCCACCAGCCCT
GCCCCCCACAGACCCCCCAAAAGGGTGAAGGCCAAGGCGGTCCCCAGCTGACCAGGGTGC
TTGGGGAGGGTGGGGCTTTTTGTAGAAACTGTGGATTCTTTTTCTCTCGTGGTCTCACTT
TGTTACTTGTTTCTGTCCCCGGGAGCCTCAGGGCTCTGAGAGCTGTGCTCCAGGCCAGGG
GTTACACCTGCCCTCCGTGGTCCCTCCCTGGGCTCCAGGGGCCTCTGGTGCGGTTCCGGG
AAGAAGCCACACCCCAGAGGTGACAGCTGAGCCCCTGCCACACCCCAGCCTCTGACTTGC
TGTGTTGTCCAGAGGTGAGGCTGGGCCCTCCCTGGTCTCCAGCTTAAACAGGAGTGAACT
CCCTCTGTCCCCAGGGCCTCCCTTCTGGGCCCCCTACAGCCCACCCTACCCCTCCTCCAT
GGGCCCTGCAGGAGGGGAGACCCACCTTGAAGTGGGGGATCAGTAGAGGCTTGCACTGCC
TTTGGGGCTGGAGGGAGACGTGGGTCCACCAGGCTTCTGGAAAAGTCCTCAATGCAATAA
AAACAATTTCTTTCTTGCAAAAAAAAAAAAAAAAAAAAAA
5' Read Nucleotide Sequence
>OriGene 5' read for NM_016539 unedited
GGACCTTGGTTTTGTATACGACTTATATAGGGCGGCCGCGAATTCGCACGAGGAGGATGT
CGGTGAATTACGCGGCGGGGCTGTCGCCGTACGCGGACAAGGGCAAGTGCGGCCTCCCGG
AGATCTTCGACCCCCCGGAGGAGCTGGAGCGGAAGGTGTGGGAACTGGCGAGGCTGGTCT
GGCAGTCTTCCAGTGTGGTGTTCCACACGGGTGCCGGCATCAGCACTGCCTCTGGCATCC
CCGACTTCAGGGGTCCCCACGGAGTCTGGACCATGGAGGAGCGAGGTCTGGCCCCCAAGT
TCGACACCACCTTTGAGAGCGCGCGGCCCACGCAGACCCACATGGCGCTGGTGCAGCTGG
AGCGCGTGGGCCTCCTCCGCTTCCTGGTCAGCCAGAACGTGGACGGGCTCCATGTGCGCT
CAGGCTTCCCCAGGGACAAACTGGCAGAGCTCCACGGGAACATGTTTGTGGAAGAATGTG
CCAAGTGTAAGACGCAGTACGTCCGAGACACAGTCGTGGGCACCATGGGCCTGAAGGCCA
CGGGCCGGCTCTGCACCGTGGCTAAGGCAAGGGGGCTGCGAGCCTGCAGGGGAGAGCTGA
GGGACACCATCCTAGACTGGGAGGACTCCCTGCCCGACCGGGACCTGGCACTCGCCGATG
AGGCCAGCAGGAACGCCGACCTGTCCATCACGCTGGGTACATCGCTGCAGATCCGGCCCA
GCGGGAACCTGCCGCTGGCTACCAAGCGCCGGGGAGGCCGCCTGGTCATCGTCAACCTGC
AGCCCACCAAGCACGACCGCCATGCTGACCTCCGCATCCATGGCTACGTTGACGAGGGTC
ATGACCCGCTCATGAAGCACCTGGGGCTGGAGATCCCCGCCTGGGACNGCCCCCGTGTGC
TGGAGAGGGCGCTNGCACCCCTGCCCCCGCCGNCCACCC
3' Read Nucleotide Sequence
>OriGene 3' read for NM_016539 unedited
NAATTAGAAACAGTTTTTATTGCATTGNAGACTTTTCCAGAACCTGGTGGACCCACGTCT
CCCTCCAGCCCCAAAGCAGTGCAAGCCTCTACTGATCCCCCACTTCAGGTGGGTCTCCCC
TCCTGCAGGGCCCATGGAGGAGGGGTAGGGTGGGCTGTAGGGGGCCCAGAAGGGAGGCCC
TGGGGACAGAGGGAGTTCACTCCTGTTTAAGCTGGAGACCAGGGAGGGCCCAGCCTCACC
TCTGGACAACACAGCAAGTCAGAGGCTGGGGTGTGGCAGGGGCTCAGCTGTCACCTCTGG
GGTGTGGCTTCTTCCCGGAACCGCACCAGAGGCCCCTGGAGCCCAGGGAGGGACCACGGA
GGGCAGGTGTAACCCCTGGCCTGGAGCACAGCTCTCAGAGCCCTGAGGCTCCCGGGGACA
GAAACAAGTAACAAAGTGAGACCACGAGAGAAAAAGAATCCACAGTTTCTACAAAAAGCC
CCACCCTCCCCAAGCACCCTGGTCAGCTGGGGACCGCCTTGGCCTTCACCCTTTTGGGGG
GTCTGTGGGGGGCAGGGCTGGTGGGCCGCTCCCGTTTGGGGCTGGCGGGCTCTGAGCCGT
TGTGCTGGGCGCAGGGCTCCTGCTTGGGGCCGGCGGGGATAGAGCCGTTGATCCGGGTGG
GAGATTCCTCCTTGGGCTCCAGCTTGGGGGTGGGCGGGCGGGGCAGGGGTGGCAGCGCCC
TCTCCAGCACACGGGGGCCGTCCCAGGCGGGGATCTCCAGCCCCCAGTGCTTTCATGACC
GGGTCATGACCTCGTCAACGTACCCTTGGATGCCGAAGTCAACCTGGCCGTCGTGCTTGG
TTGGCTGCCGGTTGACAATGACCCAGCGCCCCCCCGGCGCTTTGTAGCCAGCGGCAGGTT
CCG
Restriction Sites Please inquire |
ACCN NM_016539
Insert Size 1600 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_016539.1, NP_057623.1
RefSeq Size 1638 bp
RefSeq ORF 1068 bp
Locus ID 51548
UniProt ID Q8N6T7
Cytogenetics 19p13.3
Protein Families Druggable Genome, Transcription Factors
Summary This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Mar 2016
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Documents
Resources
"NM_016539" in other vectors (6)
SKU Description Size Price
RC202833 SIRT6 (Myc-DDK-tagged)-Human sirtuin 6 (SIRT6), transcript variant 1 10 ug
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RC202833L1 Lenti ORF clone of Human sirtuin 6 (SIRT6), transcript variant 1, Myc-DDK-tagged 10 ug
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RC202833L2 Lenti ORF clone of Human sirtuin 6 (SIRT6), transcript variant 1, mGFP tagged 10 ug
$986.00
RC202833L3 Lenti ORF clone of Human sirtuin 6 (SIRT6), transcript variant 1, Myc-DDK-tagged 10 ug
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RC202833L4 Lenti ORF clone of Human sirtuin 6 (SIRT6), transcript variant 1, mGFP tagged 10 ug
$986.00
RG202833 SIRT6 (tGFP-tagged) - Human sirtuin 6 (SIRT6), transcript variant 1 10 ug
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file-alt Citations

SIRT6 is decreased with preterm labor and regulates key terminal effector pathways of human labor in fetal membranes
Lim, Barker, Lappas
Biol. Reprod. (2013) 88 (1), 17 DOI: 10.1095/biolreprod.112.105163
Cited by 63
AI Summary: OriGene’s transfection-ready SIRT6 human cDNA clone (vector pcMV6-XL5) was used in this study to overexpress SIRT6 in primary amnion cells, enabling the authors to investigate SIRT6’s regulatory effects on inflammatory pathways involved in human labor.
Snippet: which are involved in up to 40% of cases [4]. The survivors of preterm birth have greatly increased rates of long-term disabilities ... For these studies, transfection-ready SIRT6 human cDNA clone, vector pcMV6-XL5 (Origene) was used;an empty vector was used as the control
Showing 1-1 of 1 papers.
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