SIRT6 Mouse Monoclonal Antibody [Clone ID: OTI1G3]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI1G3 |
|---|---|
| Application | IF, WB |
| Recommended Dilution | WB 1:500~2000, IF 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 88-352 of human SIRT6(NP_057623) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 38.9 kDa |
| Gene Name | sirtuin 6 |
| Database Link | |
| Background | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants. |
| Synonyms | SIR2L6 |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome, Transcription Factors |
Reviews
Documents
| Product Manuals |
| FAQs |
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Resources
Other "OTI1G3" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF503670 | Carrier-free (BSA/glycerol-free) SIRT6 mouse monoclonal antibody, clone OTI1G3 (formerly 1G3) | 100 ug |
$620.00
|
|
| TA503670AM | SIRT6 mouse monoclonal antibody, clone OTI1G3 (formerly 1G3), Biotinylated | 100 ul |
$509.00
|
|
| TA503670BM | SIRT6 mouse monoclonal antibody, clone OTI1G3 (formerly 1G3), HRP conjugated | 100 ul |
$509.00
|
|
| TA503670S | SIRT6 mouse monoclonal antibody, clone OTI1G3 (formerly 1G3) | 30 ul |
$200.00
|
|
Citations
SIRT6 deficiency culminates in low-turnover osteopenia
Sugatani, Agapova, Malluche et al
Bone (2015) 81, 168-177 DOI: 10.1016/j.bone.2015.07.018
Sugatani, Agapova, Malluche et al
Bone (2015) 81, 168-177 DOI: 10.1016/j.bone.2015.07.018
Cited by 52
AI Summary: OriGene products contributed to this study by providing the 1st strand cDNA synthesis system kit and Q-PCR assay primers, which were used for generating cDNA and performing quantitative PCR analyses to investigate gene expression related to SIRT6 deficiency and bone metabolism.
Snippet: For end-point PCR and real-time PCR, cDNA was generated using the 1st strand cDNA synthesis system kit (OriGene) following the manufacturer's suggestion. ... All primers for Q-PCR assay were purchased from OriGene. Western blotting. ... Cite SaveSaving
Showing 1-1 of 1 papers.
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