PPP2R1B (NM_181699) Human Untagged Clone
SKU
SC123371
PPP2R1B (untagged)-Human protein phosphatase 2, regulatory subunit A, beta (PPP2R1B), transcript variant 2
$612.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | PPP2R1B |
| Synonyms | PP2A-Abeta; PR65B |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_181699 |
| Insert Size | 2097 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_181699.1, NP_859050.1 |
| RefSeq Size | 2139 bp |
| RefSeq ORF | 2004 bp |
| Locus ID | 5519 |
| UniProt ID | P30154 |
| Cytogenetics | 11q23.1 |
| Protein Families | Druggable Genome, Phosphatase, Transcription Factors |
| Protein Pathways | Long-term depression, Oocyte meiosis, TGF-beta signaling pathway, Tight junction, Wnt signaling pathway |
| Summary | This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. provided by RefSeq, Apr 2010 Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (b) contains a longer and distinct C-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_181699" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC205346 | PPP2R1B (Myc-DDK-tagged)-Human protein phosphatase 2, regulatory subunit A, beta (PPP2R1B), transcript variant 2 | 10 ug |
$611.00
|
|
| RC205346L1 | Lenti ORF clone of Human protein phosphatase 2, regulatory subunit A, beta (PPP2R1B), transcript variant 2, Myc-DDK-tagged | 10 ug |
$911.00
|
|
| RC205346L2 | Lenti ORF clone of Human protein phosphatase 2, regulatory subunit A, beta (PPP2R1B), transcript variant 2, mGFP tagged | 10 ug |
$911.00
|
|
| RC205346L3 | Lenti ORF clone of Human protein phosphatase 2, regulatory subunit A, beta (PPP2R1B), transcript variant 2, Myc-DDK-tagged | 10 ug |
$911.00
|
|
| RC205346L4 | Lenti ORF clone of Human protein phosphatase 2, regulatory subunit A, beta (PPP2R1B), transcript variant 2, mGFP tagged | 10 ug |
$911.00
|
|
| RG205346 | PPP2R1B (tGFP-tagged) - Human protein phosphatase 2, regulatory subunit A, beta (PPP2R1B), transcript variant 2 | 10 ug |
$789.00
$811.00
|
|
Citations
Protein phosphatase 2A is essential to maintain active Wnt signaling and its Aβ tumor suppressor subunit is not expressed in colon cancer cells
Carmen Figueroa-Aldariz, Castañeda-Patlán, Santoyo-Ramos et al
Mol. Carcinog. (2014)
Carmen Figueroa-Aldariz, Castañeda-Patlán, Santoyo-Ramos et al
Mol. Carcinog. (2014)
Cited by 10
AI Summary: OriGene products contributed to this study by providing the plasmids encoding human PP2A-Aβ transcript variant 2 (pCMV6-XL5) and the void control (pCMV6-ZL5), which were used in rescue experiments to assess the tumor suppressor function of the Aβ isoform in colon cancer cells.
Snippet: The pTOPFlash and pFOPFlash reporter plasmids were obtained from Upstate Biotechnology. The plasmids encoding human PP2A-Aβ transcript variant 2 (pCMV6-XL5) and void control (pCMV6-ZL5) were obtained from Origene Technologies Inc (Rockville, MD). Cell ... Cite SaveSaving
Showing 1-1 of 1 papers.
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