SPSB4 (NM_080862) Human Untagged Clone
SKU
SC120350
SPSB4 (untagged)-Human splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4)
$300.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | SPSB4 |
| Synonyms | SSB-4; SSB4 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_080862 |
| Insert Size | 4350 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_080862.1, NP_543138.1 |
| RefSeq Size | 2455 bp |
| RefSeq ORF | 822 bp |
| Locus ID | 92369 |
| UniProt ID | Q96A44 |
| Cytogenetics | 3q23 |
| Domains | SPRY |
| Protein Families | Druggable Genome |
| Summary | Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558).UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_080862" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC203566 | SPSB4 (Myc-DDK-tagged)-Human splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4) | 10 ug |
$300.00
|
|
| RC203566L3 | Lenti ORF clone of Human splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), Myc-DDK-tagged | 10 ug |
$600.00
|
|
| RC203566L4 | Lenti ORF clone of Human splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), mGFP tagged | 10 ug |
$600.00
|
|
| RG203566 | SPSB4 (tGFP-tagged) - Human splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4) | 10 ug |
$500.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
