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PMS2 (NM_000535) Human Untagged Clone

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SKU
SC119825
PMS2 (untagged)-Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1
  $790.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol PMS2
Synonyms HNPCC4; MLH4; MMRCS4; PMS2CL; PMSL2
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>NCBI ORF sequence for NM_000535, the custom clone sequence may differ by one or more nucleotides


ATGGAGCGAGCTGAGAGCTCGAGTACAGAACCTGCTAAGGCCATCAAACCTATTGATCGGAAGTCAGTCC
ATCAGATTTGCTCTGGGCAGGTGGTACTGAGTCTAAGCACTGCGGTAAAGGAGTTAGTAGAAAACAGTCT
GGATGCTGGTGCCACTAATATTGATCTAAAGCTTAAGGACTATGGAGTGGATCTTATTGAAGTTTCAGAC
AATGGATGTGGGGTAGAAGAAGAAAACTTCGAAGGCTTAACTCTGAAACATCACACATCTAAGATTCAAG
AGTTTGCCGACCTAACTCAGGTTGAAACTTTTGGCTTTCGGGGGGAAGCTCTGAGCTCACTTTGTGCACT
GAGCGATGTCACCATTTCTACCTGCCACGCATCGGCGAAGGTTGGAACTCGACTGATGTTTGATCACAAT
GGGAAAATTATCCAGAAAACCCCCTACCCCCGCCCCAGAGGGACCACAGTCAGCGTGCAGCAGTTATTTT
CCACACTACCTGTGCGCCATAAGGAATTTCAAAGGAATATTAAGAAGGAGTATGCCAAAATGGTCCAGGT
CTTACATGCATACTGTATCATTTCAGCAGGCATCCGTGTAAGTTGCACCAATCAGCTTGGACAAGGAAAA
CGACAGCCTGTGGTATGCACAGGTGGAAGCCCCAGCATAAAGGAAAATATCGGCTCTGTGTTTGGGCAGA
AGCAGTTGCAAAGCCTCATTCCTTTTGTTCAGCTGCCCCCTAGTGACTCCGTGTGTGAAGAGTACGGTTT
GAGCTGTTCCGATGCTCTGCATAATCTTTTTTACATCTCAGGTTTCATTTCACAATGCACGCATGGAGTT
GGAAGGAGTTCAACAGACAGACAGTTTTTCTTTATCAACCGGCGGCCTTGTGACCCAGCAAAGGTCTGCA
GACTCGTGAATGAGGTCTACCACATGTATAATCGACACCAGTATCCATTTGTTGTTCTTAACATTTCTGT
TGATTCAGAATGCGTTGATATCAATGTTACTCCAGATAAAAGGCAAATTTTGCTACAAGAGGAAAAGCTT
TTGTTGGCAGTTTTAAAGACCTCTTTGATAGGAATGTTTGATAGTGATGTCAACAAGCTAAATGTCAGTC
AGCAGCCACTGCTGGATGTTGAAGGTAACTTAATAAAAATGCATGCAGCGGATTTGGAAAAGCCCATGGT
AGAAAAGCAGGATCAATCCCCTTCATTAAGGACTGGAGAAGAAAAAAAAGACGTGTCCATTTCCAGACTG
CGAGAGGCCTTTTCTCTTCGTCACACAACAGAGAACAAGCCTCACAGCCCAAAGACTCCAGAACCAAGAA
GGAGCCCTCTAGGACAGAAAAGGGGTATGCTGTCTTCTAGCACTTCAGGTGCCATCTCTGACAAAGGCGT
CCTGAGACCTCAGAAAGAGGCAGTGAGTTCCAGTCACGGACCCAGTGACCCTACGGACAGAGCGGAGGTG
GAGAAGGACTCGGGGCACGGCAGCACTTCCGTGGATTCTGAGGGGTTCAGCATCCCAGACACGGGCAGTC
ACTGCAGCAGCGAGTATGCGGCCAGCTCCCCAGGGGACAGGGGCTCGCAGGAACATGTGGACTCTCAGGA
GAAAGCGCCTGAAACTGACGACTCTTTTTCAGATGTGGACTGCCATTCAAACCAGGAAGATACCGGATGT
AAATTTCGAGTTTTGCCTCAGCCAACTAATCTCGCAACCCCAAACACAAAGCGTTTTAAAAAAGAAGAAA
TTCTTTCCAGTTCTGACATTTGTCAAAAGTTAGTAAATACTCAGGACATGTCAGCCTCTCAGGTTGATGT
AGCTGTGAAAATTAATAAGAAAGTTGTGCCCCTGGACTTTTCTATGAGTTCTTTAGCTAAACGAATAAAG
CAGTTACATCATGAAGCACAGCAAAGTGAAGGGGAACAGAATTACAGGAAGTTTAGGGCAAAGATTTGTC
CTGGAGAAAATCAAGCAGCCGAAGATGAACTAAGAAAAGAGATAAGTAAAACGATGTTTGCAGAAATGGA
AATCATTGGTCAGTTTAACCTGGGATTTATAATAACCAAACTGAATGAGGATATCTTCATAGTGGACCAG
CATGCCACGGACGAGAAGTATAACTTCGAGATGCTGCAGCAGCACACCGTGCTCCAGGGGCAGAGGCTCA
TAGCACCTCAGACTCTCAACTTAACTGCTGTTAATGAAGCTGTTCTGATAGAAAATCTGGAAATATTTAG
AAAGAATGGCTTTGATTTTGTTATCGATGAAAATGCTCCAGTCACTGAAAGGGCTAAACTGATTTCCTTG
CCAACTAGTAAAAACTGGACCTTCGGACCCCAGGACGTCGATGAACTGATCTTCATGCTGAGCGACAGCC
CTGGGGTCATGTGCCGGCCTTCCCGAGTCAAGCAGATGTTTGCCTCCAGAGCCTGCCGGAAGTCGGTGAT
GATTGGGACTGCTCTTAACACAAGCGAGATGAAGAAACTGATCACCCACATGGGGGAGATGGACCACCCC
TGGAACTGTCCCCATGGAAGGCCAACCATGAGACACATCGCCAACCTGGGTGTCATTTCTCAGAACTGA

5' Read Nucleotide Sequence
>OriGene 5' read for NM_000535 unedited
AGAATTTGTATACGACTCATATAGGCGGCCGCGNATTCGGCACGAGGCTGGAGGGAACTT
TCCCAGTCCCCGAGGCGGATCGGGTGTTGCATCCATGGAGCGAGCTGAGAGCTCGAGTAC
AGAACCTGCTAAGGCCATCAAACCTATTGATCGGAAGTCAGTCCATCAGATTTGCTCTGG
GCAGGTGGTACTGAGTCTAAGCACTGCGGTAAAGGAGTTAGTAGAAAACAGTCTGGATGC
TGGTGCCACTAATATTGATCTAAAGCTTAAGGACTATGGAGTGGATCTTATTGAAGTTTC
AGACAATGGATGTGGGGTAGAAGAAGAAAACTTCGAAGGCTTAACTCTGAAACATCACAC
ATCTAAGATTCAAGAGTTTGCTGACCTAACTCAGGTTGAAACTTTTGGCTTTCGGGGGGA
AGCTCTGAGCTCACTTTGTGCACTGAGCGATGTCACCATTTCTACCTGCCACGCATCGGC
GAAGGTTGGAACTCGACTGATGTTTGATCACAATGGGAAAATTATCCAGAAAACCCCCTA
CCCCCGCCCCAGAGGGACCACAGTCAGCGTGCAGCAGTTATTTTCCACACTACCTGTGCG
CCATAAGGAATTTCAAAGGAATATTAAGAAGGAGTATGCCAAAATGGTCCAGGTCTTACA
TGCATACTGTATCATTTCAGCAGGCATCCGTGTAAGTTGCACCAATCAGCTTGGACAAGG
AAAACGACAGCCTGTGGTATGCACAGGTGGAAGCCCCAGCATAAAGGAAAATATCGGCTC
TGTGTTTGGGCAGAAGCAGTTGCAAAGCCTCATTCCTTTTGTTCAGCTGCCCCCTAGTGA
CTNCGTGTGTGAAGAGTACGGTTTGAGCTGTTCNGATGCTCTGCATAATCTTTTTACATC
TCAGGNTTCATTTCACATGCACGCTGGANNTGGGGGNAGTTCACAGACAGACC
3' Read Nucleotide Sequence
>OriGene 3' read for NM_000535 unedited
GCCCGAATCTAGAATCGAGTTTTTTTTTTTTTTTTTTGTTTTGGTTTTTGAAACACAGTC
TTGCTCTATCTCACCCAGGCTGGAGCGCAGTGGCGCAATCTCGGTTCACTGCAACCTCCG
TCTCCCGGGCCCAAGCGATTCTCCCGCCTCAGCCTCCTGGGTAGCGGGGATCACAGGCAT
GCGCCAGCACACCTGGCTAATTTTGTATTTTTAGTAAAGGCAGGGTTTCTCCATGTTGGT
CAAGCTGGTCTCGAACTTCTGATCTCAGGTGATCCGCCGGCCTCGGCCTCCCAAAGTGCT
GCGATCACAGGCATGAGCCACCATGCCCAGCCCAAGTGTTCTTATTTTTATAAAATGTGT
TCTTGCCTGGACACACACACACGAGCGCATGCAAACATAGAGAAAAAAAATTTGCAAGCA
ATGCTCCATCTGGTTTGAAAAGGGTCTCAAGATCACTTTTAAATGGGTGTGATGTGTATT
TTTTTTAAGTAGCAGGTTCATTTCAAAACAAAAAAGGTTAGTGAAGACTCTGTCTTTCAA
AACATAAAAATCTGCGATAAAACCAATTATTCCATACAGTGACTACGGTCAGTTCTGAGA
AATGACACCCAAGTTGGCGATGTGTCTCATGTTTGGCCTTCCATGGGGACAGTTCCAGAG
GTGGTCCATTTCCCCCATGTGGGAGATCAGTTTCTTCATTTCGCTTGTGGTTAAAAGCAG
TCCCAATCATTACCGACTTCCGGCAGGGCTCTGTGAGGCAAACATCTGCTTTGACTCTCG
GAAAGGCCGGAACAAGAACCCCAAGGCCTGGCGCCCAACCTTGATTATCATTTAATTCAA
CGCACTGGGTGCCCGAAGTGCCAATTTCTACATTATTGGCAAGAAAAACATTTATACCCT
ATACAAGACTAGAGCACTTCTTTCCGCTAACATAAATAAAGCCACTCCTTTCTTAAATAT
TCCCACTATTTTTTTAACAACCCTCCAANATAACCAGGTAGTCGAGAGACTCGAGTGCCT
ACAC
Restriction Sites NotI-NotI |
ACCN NM_000535
Insert Size 3090 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_000535.3, NP_000526.1
RefSeq Size 2851 bp
RefSeq ORF 2589 bp
Locus ID 5395
UniProt ID P54278
Cytogenetics 7p22.1
Domains DNA_mis_repair, HATPase_c
Protein Families Druggable Genome
Protein Pathways Mismatch repair
Summary The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. provided by RefSeq, Apr 2016
Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
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Documents
Resources
"NM_000535" in other vectors (6)
SKU Description Size Price
RC210880 PMS2 (Myc-DDK-tagged)-Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1 10 ug
$1,184.00
RC210880L1 Lenti ORF clone of Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1, Myc-DDK-tagged 10 ug
$1,484.00
RC210880L2 Lenti ORF clone of Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1, mGFP tagged 10 ug
$1,484.00
RC210880L3 Lenti ORF clone of Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1, Myc-DDK-tagged 10 ug
$1,484.00
RC210880L4 Lenti ORF clone of Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1, mGFP tagged 10 ug
$1,484.00
RG210880 PMS2 (tGFP-tagged) - Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1 10 ug
$1,384.00

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