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Catalase (CAT) (NM_001752) Human Untagged Clone

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SKU
SC119081
CAT (untagged)-Human catalase (CAT)
  $492.00
In Stock*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol Catalase
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC119081 sequence for NM_001752 edited (data generated by NextGen Sequencing)
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAGAAAGCTGATGTCCTGACCACTGGAGCTGGTAACCCAGTAGGAGACAAACTTAAT
GTTATTACAGTAGGGCCCCGTGGGCCCCTTCTTGTTCAGGATGTGGTTTTCACTGATGAA
ATGGCTCATTTTGACCGAGAGAGAATTCCTGAGAGAGTTGTGCATGCTAAAGGAGCAGGG
GCCTTTGGCTACTTTGAGGTCACACATGACATTACCAAATACTCCAAGGCAAAGGTATTT
GAGCATATTGGAAAGAAGACTCCCATCGCAGTTCGGTTCTCCACTGTTGCTGGAGAATCG
GGTTCAGCTGACACAGTTCGGGACCCTCGTGGGTTTGCAGTGAAATTTTACACAGAAGAT
GGTAACTGGGATCTCGTTGGAAATAACACCCCCATTTTCTTCATCAGGGATCCCATATTG
TTTCCATCTTTTATCCACAGCCAAAAGAGAAATCCTCAGACACATCTGAAGGATCCGGAC
ATGGTCTGGGACTTCTGGAGCCTACGTCCTGAGTCTCTGCATCAGGTTTCTTTCTTGTTC
AGTGATCGGGGGATTCCAGATGGACATCGCCACATGAATGGATATGGATCACATACTTTC
AAGCTGGTTAATGCAAATGGGGAGGCAGTTTATTGCAAATTCCATTATAAGACTGACCAG
GGCATCAAAAACCTTTCTGTTGAAGATGCGGCGAGACTTTCCCAGGAAGATCCTGACTAT
GGCATCCGGGATCTTTTTAACGCCATTGCCACAGGAAAGTACCCCTCCTGGACTTTTTAC
ATCCAGGTCATGACATTTAATCAGGCAGAAACTTTTCCATTTAATCCATTCGATCTCACC
AAGGTTTGGCCTCACAAGGACTACCCTCTCATCCCAGTTGGTAAACTGGTCTTAAACCGG
AATCCAGTTAATTACTTTGCTGAGGTTGAACAGATAGCCTTCGACCCAAGCAACATGCCA
CCTGGCATTGAGGCCAGTCCTGACAAAATGCTTCAGGGCCGCCTTTTTGCCTATCCTGAC
ACTCACCGCCATCGCCTGGGACCCAATTATCTTCATATACCTGTGAACTGTCCCTACCGT
GCTCGAGTGGCCAACTACCAGCGTGATGGCCCGATGTGCATGCAGGACAATCAGGGTGGT
GCTCCAAATTACTACCCCAACAGCTTTGGTGCTCCGGAACAACAGCCTTCTGCCCTGGAG
CACAGCATCCAATATTCTGGAGAAGTGCGGAGATTCAACACTGCCAATGATGATAACGTT
ACTCAGGTGCGGGCATTCTATGTGAACGTGCTGAATGAGGAACAGAGGAAACGTCTGTGT
GAGAACATTGCCGGCCACCTGAAGGATGCACAAATTTTCATCCAGAAGAAAGCGGTCAAG
AACTTCACTGAGGTCCACCCTGACTACGGGAGCCACATCCAGGCTCTTCTGGACAAGTAC
AATGCTGAGAAGCCTAAGAATGCGATTCACACCTTTGTGCAGTCCGGATCTCACTTGGCG
GCAAGGGAGAAGGCAAATCTGTGA

Clone variation with respect to NM_001752.3
1167 c=>t
5' Read Nucleotide Sequence
>OriGene 5' read for NM_001752 unedited
GGTTGNAATTTGTATACGACTCACTATAGGGCGGCCGCGCAATTCGCACGAGGACGAGCC
GAGGCCTCCTGCAGTGTTCTGCACAGCAAACCGCACGCTATGGCTGACAGCCGGGATCCC
GCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCCGCGCAGAAAGCTGATGTCCTG
ACCACTGGAGCTGGTAACCCAGTAGGAGACAAACTTAATGTTATTACAGTAGGGCCCCGT
GGGCCCCTTCTTGTTCAGGATGTGGTTTTCACTGATGAAATGGCTCATTTTGACCGAGAG
AGAATTCCTGAGAGAGTTGTGCATGCTAAAGGAGCAGGGGCCTTTGGCTACTTTGAGGTC
ACACATGACATTACCAAATACTCCAAGGCAAAGGTATTTGAGCATATTGGAAAGAAGACT
CCCATCGCAGTTCGGTTCTCCACTGTTGCTGGAGAATCGGGTTCAGCTGACACAGTTCGG
GACCCTCGTGGGTTTGCAGTGAAATTTTACACAGAAGATGGTAACTGGGATCTCGTTGGA
AATAACACCCCCATTTTCTTCATCAGGGATCCCATATTGTTTCCATCTTTTATCCACAGC
CAAAAGAGAAATCCTCAGACACATCTGAAGGATCCGGACATGGTCTGGGACTTCTGGAGC
CTACGTCCTGAGTCTCTGCATCACGTTTCTTTCTTGTTCAGTGATCCGGGGATTCCAGAT
GGACATCGCCACATGAATGGATATGGATCACATACTCTCCAGCCTGTTTAATGCCAAATG
GGGAGGCAGTTTATTGCAAATTCCATTATAAGACTGACCACGGCATCAAAAACCTTTCTG
TTGAAGATCCGGCGAGACTTTCCCANGAAGAATCTGACTATGGCATCCGGGGATCTTTTT
ACCGCCATTGCCCCAGNAAAGTCN
3' Read Nucleotide Sequence
>OriGene 3' read for NM_001752 unedited
NNNTTTTTAGCTATGGACCCGCGGCCGCAATCTAGNGTCGAGTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTACGGACAGATTATTTATTGGAAAAATGTAAGCAATTACA
AATTGATCTGTTGGGAAATCAGGGCTGAATTAACATTAATGTAACTCCAGGGAAAAAAAT
GAATTTGATCAATTATTATCATTAATAAACATTAAGCCATGACGGGGCTCAAGTTATCTT
CTGATGACACTGCTGTATTAAATGTACTTTTCCTATGAAAACCTTAAAAAAATAAAAATT
TCTGAGGAAAACATCTTTATCTTTTCTTTTTATATATTTATAGCCATATTTTAATATAAT
AGGCCATGAGGGGATATGTAAACATACATAATTTCAACAAATTTTGTCAAATAAAATCAT
ATTTCTAGCTAGAAACTTGCCTTCTAATCATTTTAAATGAATAATCCAATCATCCGTCAA
AACAAATTTTTTTTTTAAATGACTGTTAAATCCTAACCTTCATTTTCCCCTGGGGAAATA
GCATTAAAATTGTTACACAATCTGCTATAGAAAGTGGGATTCTCTATTTTGAAGCCACTA
GCTTGCATTTGCACATCTAGCACAGGAGAATCTTCATCCAGTGATGAGCGGGTTACACCG
GATGAACGCTAAGCTTCGCTGCACAGGTGCAGGGCCCCGGCCTCACAGATTTGCCTTCTC
CCTTGCCGCCAAGTGAGATCCGGACTGCACAAAGGTGTGAATCGCATTCTAAGGCTTTTC
AGCATTGCACTTGCCCAAAAAGCCTGAATGTGCCTCCCGTATCCAGGTGGACCTCAGTGA
AGTCTTGACCGTTTTCTCTGGAAGAAAATTTGGCATCCTTCAGGTGCCCGCAATGTTC
Restriction Sites NotI-NotI |
ACCN NM_001752
Insert Size 2150 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001752.2, NP_001743.1
RefSeq Size 2305 bp
RefSeq ORF 1584 bp
Locus ID 847
UniProt ID P04040
Cytogenetics 11p13
Domains catalase
Protein Families Druggable Genome
Protein Pathways Amyotrophic lateral sclerosis (ALS), Metabolic pathways, Methane metabolism, Tryptophan metabolism
Summary This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. provided by RefSeq, Oct 2009
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Documents
Resources
"NM_001752" in other vectors (6)
SKU Description Size Price
RC210763 CAT (Myc-DDK-tagged)-Human catalase (CAT) 10 ug
$491.00
RC210763L1 Lenti ORF clone of Human catalase (CAT), Myc-DDK-tagged 10 ug
$791.00
RC210763L2 Lenti ORF clone of Human catalase (CAT), mGFP tagged 10 ug
$791.00
RC210763L3 Lenti ORF clone of Human catalase (CAT), Myc-DDK-tagged 10 ug
$791.00
RC210763L4 Lenti ORF clone of Human catalase (CAT), mGFP tagged 10 ug
$791.00
RG210763 CAT (tGFP-tagged) - Human catalase (CAT) 10 ug
$489.00 $691.00

file-alt Citations

Immunocytochemical staining of endogenous nuclear proteins with the HIS-1 anti-poly-histidine monoclonal antibody: A potential source of error in His-tagged protein detection
Chilumuri, Markiv, Milton
Acta Histochem. (2014)
Cited by 8
AI Summary: OriGene contributed to this study by providing the human catalase cDNA clone (NM_001752.3), which was used to generate histidine-tagged catalase for immunocytochemical analysis.
Snippet: The human catalase cDNA clone (NM_001752.3) was obtained from Origene and PCR cloned into the pcDNA4/TO/myc–His expression vector using forward (5′- AAGCTTATGGCTGACAGCCGGGAT-3′) and reverse (5′-GCGGCCGCCAGATTTGCCTT ... Cite SaveSaving
Autophagy is a cell self-protective mechanism against arsenic-induced cell transformation
Zhang, Qi, Liao et al
Toxicol. Sci. (2012) 130 (2), 298-308 DOI: 10.1093/toxsci/kfs240
Cited by 88
AI Summary: In this study, OriGene’s catalase DNA plasmid (NM_001752) and SOD1 DNA plasmid (NM_000454) were used to investigate the roles of antioxidant enzymes in modulating autophagy and reactive oxygen species during arsenic-induced cell transformation.
Snippet: For short-term (≤ 72h) arsenic exposure, cells were grown to 80–90% confluence before treated with 0.25µM sodium arsenite ... Beclin 1 shRNA plasmid (SA Biosciences, KH05670N), catalase DNA plasmid, and SOD1 DNA plasmid (Origene, NM_001752 and NM_000454) have
The effects of catalase and kisspeptin overexpression on amyloid peptide toxicity
Chilumuri
Thesis (2014)
Snippet: The cDNA clones for the human catalase gene (NM_001752.3) and the human KiSS-1 gene (NM_002256.2) were obtained from Origene and the genes were amplified from the cDNAs (Origene) using the polymerase chain reaction (PCR) with the following primers (Table 1) (Invitrogen)
Showing 1-3 of 3 papers.
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