XPC (NM_004628) Human Untagged Clone
SKU
SC117234
XPC (untagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1
$1,292.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | XPC |
| Synonyms | p125; RAD4; XP3; XPCC |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_004628 |
| Insert Size | 4000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_004628.3, NP_004619.2 |
| RefSeq Size | 3714 bp |
| RefSeq ORF | 2823 bp |
| Locus ID | 7508 |
| UniProt ID | Q01831 |
| Cytogenetics | 3p25.1 |
| Domains | Rad4 |
| Protein Families | Druggable Genome |
| Protein Pathways | Nucleotide excision repair |
| Summary | The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. provided by RefSeq, Aug 2017 Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_004628" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC204483 | XPC (Myc-DDK-tagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1 | 10 ug |
$1,291.00
|
|
| RC204483L1 | Lenti-ORF clone of XPC (Myc-DDK-tagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1 | 10 ug |
$1,591.00
|
|
| RC204483L2 | Lenti-ORF clone of XPC (mGFP-tagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1 | 10 ug |
$1,591.00
|
|
| RC204483L3 | Lenti-ORF clone of XPC (Myc-DDK-tagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1 | 10 ug |
$1,591.00
|
|
| RC204483L4 | Lenti-ORF clone of XPC (mGFP-tagged)-Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1 | 10 ug |
$1,591.00
|
|
| RG204483 | XPC (tGFP-tagged) - Human xeroderma pigmentosum, complementation group C (XPC), transcript variant 1 | 10 ug |
$1,491.00
|
|
Citations
Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair
Shah, Zhao, Qiang et al
Nucleic Acids Res. (2018)
Shah, Zhao, Qiang et al
Nucleic Acids Res. (2018)
AI Summary: OriGene’s pCMV6-XL5 vector containing the human XPC gene was used as the source for sub-cloning XPC, enabling the study of XPC phosphorylation and its role in DNA repair regulation after UV-induced damage.
Snippet: uments) was used to monitor the UVB dose weekly. There is no detectable UVC emission from our system. PLASMIDS AND SITE-DIRECTED MUTAGENESIS Human XPC gene was sub-cloned from the pCMV6-XL5 vector (Origene) to a Gateway pENTR vector (Invitrogen). The resulting pENTR-XPC was used for a recombination reaction with pLenti CMV Puro Dest destination vector (Addgene, 17452;deposited by Eric Campeau)
Showing 1-1 of 1 papers.
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