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TPX2 (NM_012112) Human Untagged Clone

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SKU
SC115515
TPX2 (untagged)-Human TPX2, microtubule-associated, homolog (Xenopus laevis) (TPX2)
  $685.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol TPX2
Synonyms C20orf1; C20orf2; DIL-2; DIL2; FLS353; GD:C20orf1; HCA519; HCTP4; p100; REPP86
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_012112 edited
GAATTCGGCACGAGGGCGAGGCTAGGTGAGCCGTGGGAAGAAAAGAGGGAGCAGCTAGGG
CGCGGGTCTCCCTCCTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCG
CCGTTCGCGCCGCTAGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCGCCTAGGC
GGGGCAGGGTGCGAGCAGGGGCTTCGGGCCACGCTTCTCTTGGCGACAGGATTTTGCTGT
GAAGTCCGTCCGGGAAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGG
TTCTTGATACATATTTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGC
AACTTTGAGTCAGACCTGTAGGCCTGATAGACTGATTAAACCACAGAAGGTGACCTGCTG
AGAAAAGTGGTACAAATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGT
CACAAGTTAAAAGCTCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCT
TGGATGATGAAGGAGATACTCAAAACATAGATTCATGGTTTGAGGAGAAGGCCAATTTGG
AGAATAAGTTACTGGGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGA
GAAAGGCTAATCTTCAGCAAGCTATTGTCACACCTTTGAAACCAGTTGACAACACTTACT
ACAAAGAGGCAGAAAAAGAAAATCTTGTGGAACAATCCATTCCGTCAAATGCTTGTTCTT
CCCTGGAAGTTGAGGCAGCCATATCAAGAAAAACTCCAGCCCAGCCTCAGAGAAGATCTC
TTAGGCTTTCTGCTCAGAAGGATTTGGAACAGAAAGAAAAGCATCATGTAAAAATGAAAG
CCAAGAGATGTGCCACTCCTGTAATCATCGATGAAATTCTACCCTCTAAGAAAATGAAAG
TTTCTAACAACAAAAAGAAGCCAGAGGAAGAAGGCAGTGCTCATCAAGATACTGCTGAAA
AGAATGCATCTTCCCCAGAGAAAGCCAAGGGTAGACATACTGTGCCTTGTATGCCACCTG
CAAAGCAGAAGTTTCTAAAAAGTACTGAGGAGCAAGAGCTGGAGAAGAGTATGAAAATGC
AGCAAGAGGTGGTGGAGATGCGGAAAAAGAATGAAGAATTCAAGAAACTTGCTCTGGCTG
GAATAGGGCAACCTGTGAAGAAATCAGTGAGCCAGGTCACCAAATCAGTTGACTTCCACT
TCCGCACAGATGAGCGAATCAAACAACATCCTAAGAACCAGGAGGAATATAAGGAAGTGA
ACTTTACATCTGAACTACGAAAGCATCCTTCATCTCCTGCCCGAGTGACTAAGGGATGTA
CCATTGTTAAGCCTTTCAACCTGTCCCAAGGAAAGAAAAGAACATTTGATGAAACAGTTT
CTACATATGTGCCCCTTGCACAGCAAGTTGAAGACTTCCATAAACGAACCCCTAACAGAT
ATCATTTGAGGAGCAAGAAGGATGATATTAACCTGTTACCCTCCAAATCTTCTGTGACCA
AGATTTGCAGAGACCCACAGACTCCTGTACTGCAAACCAAACACCGTGCACGGGCTGTGA
CCTGCAAAAGTACAGCAGAGCTGGAGGCTGAGGAGCTCGAGAAATTGCAACAATACAAAT
TCAAAGCACGTGAACTTGATCCCAGAATACTTGAAGGTGGGCCCATCTTGCCCAAGAAAC
CACCTGTGAAACCACCCACCGAGCCTATTGGCTTTGATTTGGAAATTGAGAAAAGAATCC
AGGAGCGAGAATCAAAGAAGAAAACAGAGGATGAACACTTTGAATTTCATTCCAGACCTT
GCCCTACTAAGATTTTGGAAGATGTTGTGGGTGTTCCTGAAAAGAAGGTACTTCCAATCA
CCGTCCCCAAGTCACCAGCCTTTGCATTGAAGAACAGAATTCGAATGCCCACCAAAGAAG
ATGAGGAAGAGGACGAACCGGTAGTGATAAAAGCTCAACCTGTGCCACATTATGGGGTGC
CTTTTAAGCCCCAAATCCCAGAGGCAAGAACTGTGGAAATATGCCCTTTCTCGTTTGATT
CTCGAGACAAAGAACGTCAGTTACAGAAGGAGAAGAAAATAAAAGAACTGCAGAAAGGGG
AGGTGCCCAAGTTCAAGGCACTTCCCTTGCCTCATTTTGACACCATTAACCTGCCAGAGA
AGAAGGTAAAGAATGTGACCCAGATTGAACCTTTCTGCTTGGAGACTGACAGAAGAGGTG
CTCTGAAGGCACAGACTTGGAAGCACCAGCTGGAAGAAGAACTGAGACAGCAGAAAGAAG
CAGCTTGTTTCAAGGCTCGTCCAAACACCGTCATCTCTCAGGAGCCCTTTGTTCCCAAGA
AAGAGAAGAAATCAGTTGCTGAGGGCCTTTCTGGTTCTCTAGTTCAGGAACCTTTTCAGC
TGGCTACTGAGAAGAGAGCCAAAGAGCGGCAGGAGCTGGAGAAGAGAATGGCTGAGGTAG
AAGCCCAGAAAGCCCAGCAGTTGGAGGAGGCCAGACTACAGGAGGAAGAGCAGAAAAAAG
AGGAGCTGGCCAGGCTACGGAGAGAACTGGTGCATAAGGCAAATCCAATACGCAAGTACC
AGGGTCTGGAGATAAAGTCAAGTGACCAGCCTCTGACTGTGCCTGTATCTCCCAAATTCT
CCACTCGATTCCACTGCTAAACTCAGCTGTGAGCTGCGGATACCGCCCGGCAATGGGACC
TGCTCTTAACCTCAAACCTAGGACCGTCTTGCTTTGTCATTGGGCATGGAGAGAACCCAT
TTCTCCAGACTTTTACCTACCCGTGCCTGAGAAAGCATACTTGACAACTGTGGACTCCAG
TTTTGTTGAGAATTGTTTTCTTACATTACTAAGGCTAATAATGAGATGTAACTCATGAAT
GTCTCGATTAGACTCCATGTAGTTACTTCCTTTAAACCATCAGCCGGCCTTTTATATGGG
TCTTCACTCTGACTAGAATTTAGTCTCTGTGTCAGCACAGTGTAATCTCTATTGCTATTG
CCCCTTACGACTCTCACCCTCTCCCCACTTTTTTTAAAAATTTTAACCAGAAAATAAAGA
TAGTTAAATCCTAAGATAGAGATTAAGTCATGGTTTAAATGAGGAACAATCAGTAAATCA
GATTCTGTCCTCTTCTCTGCATACCGTGAATTTATAGTTAAGGATCCCTTTGCTGTGAGG
GTAGAAAACCTCACCAACTGCACCAGTGAGGAAGAAGACTGCGTGGATTCATGGGGAGCC
TCACAGCAGCCACGTAGCAGGCTCTGGGTGGGGCTGCCGTTAAGGCACGTTCTTTCCTTA
CTGGTGCTGATAACAACAGGGAACCGTGCAGTGTGCATTTTAAGACCTGGCCTGGAATAA
ATACGTTTTGTCTTTCCCTCAAAAAAAAAAAAAAAAAACTCGAC
5' Read Nucleotide Sequence
>OriGene 5' read for NM_012112 unedited
GAAGCACTTCGGATTTGTAAACCCGNATTCACTATNAGGGCGGACGCCAATTCGGCACGA
GGGCGAGGCTAGGTGAGCCGTGGGAAGAAAAGAGGAGCAGCTAGGGCGCGGGTCTCCCTC
CTCCCGGAGTTTGGAACGGCTGAAGTTCACCTTCCAGCCCCTAGCGCCGTTCGCGCCGCT
AGGCCTGGCTTCTGAGGCGGTTGCGGTGCTCGGTCGCCTTTTATGCGGGGCAGGGTGCGA
GCAGGGGCTTCGGGCCACGCTTCTCTTGGCGACAGGATTTTGCTGTGAAGTCCGTCCGGG
AAACGGAGGAAAAAAAGAGTTGCGGGAGGCTGTCGGCTAATAACGGTTCTTGATACATAT
TTGCCAGACTTCAAGATTTCAGAAAAGGGGTGAAAGAGAAGATTGCAACTTTGAGTCAGA
CCTGTAGGCCTGATAGACTGATTAAACCACAGAAGGTGACCTGCTGAGAAAAGTGGTACA
AATACTGGGAAAAACCTGCTCTTCTGCGTTAAGTGGGAGACAATGTCACAAGTTAAAAGC
TCTTATTCCTATGATGCCCCCTCGGATTTCATCAATTTTTCATCCTTGGATGATGAAGGA
GATACTCAAAACATAGATTCATGGTTTGAGGAGAAGGCCAATTTGGAGAATAAGTTACTG
GGGAAGAATGGAACTGGAGGGCTTTTTCAGGGCAAAACTCCTTTGAGAAAGGCTAATCTT
CAGCAAGCTATTGTCACACCTTTGAAACCAGTTGANCACACTTACTACAAAGAGGCAGAA
AAAGAAAATCTTGTGGAACAATCCATTCCGTCAAATGCTTGTTCTTCCCTGGAAGTTTGA
GCAGCCATATCAAGANAACTCCAGCCCAGCCTCAGAAN
3' Read Nucleotide Sequence
>OriGene 3' read for NM_012112 unedited
CAGTGNAGATCGAGTTTTTTTTTTTTTTTTTTGAGGGAAAGACAAACGTATTTATTCCAG
GCCAGGTCTTAAAATGCACACTGCACGGTTCCCTGTTGTTATCAGCACCAGTAAGGAAAG
AACGTGCCTTAACGGCAGCCCCACCCAGAGCCTGCTACGTGGCTGCTGTGAGGCTCCCCA
TGAATCCACGCAGTCTTCTTTCTCACTGGTGCAGTTGGTGAGGTTTTCTACCCTCACAGC
AAAGGGATCCTTAACTATAAATTCACGGTATGCAGAGAAGAGGACAGAATCTGATTTACT
GATTGTTCCTCATTTAAACCATGACTTAATCTCTATCTTAGGATTTAACTATCTTTATTT
TCTGGTTAAAATTTTTAAAAAAAGTGGGGAGAGGGTGAGAGTCGTAAGGGGCAATAGCAA
TAGAGATTACACTGTGCTGACACAGAGACTAAATTCTAGTCAGAGTGAAGACCCATATAA
AAGGCCGGCTGATGGTTTAAAGGAAGTAACTACATGGAGTCTAATCGAGACATTCATGAG
TTACATCTCATTATTAGCCTTAGTAATGTAAGAAAACAATTCTCAACAAAACTGGAGTCC
ACAGTTGTCAAGTATGCTTTCTCAGGCACGGGTAGGTAAAAGTCTGGAGAAATGGGTTCT
CTCCATGCCCAATGACAAAGCAAGACGGTCCTANGTTTGAGGTTAAGAGCANGTCCCATT
GCCGGGCGGTATCCGCAGCTCACAGCTGAGTTACCAGTGAATCGAGTGGAGATTTGGGAG
AACAGGACAGTCAGAGCTGTCACTTGACTTATCTCCAACCCTGTACTTGCCATTGGATTG
CCTATGCACAGTTTTCTCGTAGCTGGCAGCTCTCTTTTCTGCCTCCTCCGGAGCGGCCTC
CCACTGCTGGCTTTTGGCTTTACTAACAATTTTTTCAGTCTGCGGTTTGGTTTTTTAANA
CCATGAAAGTCCGACCAAAAAA
Restriction Sites NotI-NotI |
ACCN NM_012112
Insert Size 3460 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_012112.4, NP_036244.2
RefSeq Size 3685 bp
RefSeq ORF 2244 bp
Locus ID 22974
UniProt ID Q9ULW0
Cytogenetics 20q11.21
Protein Families Druggable Genome, Stem cell - Pluripotency
Summary Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_012112" in other vectors (6)
SKU Description Size Price
RC205821 TPX2 (Myc-DDK-tagged)-Human TPX2, microtubule-associated, homolog (Xenopus laevis) (TPX2) 10 ug
$684.00
RC205821L1 Lenti ORF clone of Human TPX2, microtubule-associated, homolog (Xenopus laevis) (TPX2), Myc-DDK-tagged 10 ug
$984.00
RC205821L2 Lenti ORF clone of Human TPX2, microtubule-associated, homolog (Xenopus laevis) (TPX2), mGFP tagged 10 ug
$984.00
RC205821L3 Lenti ORF clone of Human TPX2, microtubule-associated, homolog (Xenopus laevis) (TPX2), Myc-DDK-tagged 10 ug
$984.00
RC205821L4 Lenti ORF clone of Human TPX2, microtubule-associated, homolog (Xenopus laevis) (TPX2), mGFP tagged 10 ug
$984.00
RG205821 TPX2 (tGFP-tagged) - Human TPX2, microtubule-associated, homolog (Xenopus laevis) (TPX2) 10 ug
$789.00 $884.00

file-alt Citations

Differences in Mitotic Spindle Architecture in Mammalian Neural Stem Cells Influence Mitotic Accuracy during Brain Development
Vargas-Hurtado, Brault, Piolot et al
Curr. Biol. (2019) 29 (18), 2993-3005.e9 DOI: 10.1016/j.cub.2019.07.061
AI Summary: OriGene’s TPX2 (NM_012112) Human untagged clone (Cat# SC115515) was used in this study to investigate the role of TPX2 in determining mitotic spindle architecture and its impact on chromosome segregation accuracy in neural stem cells during brain development.
Snippet: TPX2 (NM_012112) Human untagged clone Origene Cat#SC115515
Showing 1-1 of 1 papers.
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