FLRT2 (NM_013231) Human Untagged Clone
$615.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | FLRT2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_013231 |
| Insert Size | 4150 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_013231.4, NP_037363.1 |
| RefSeq Size | 7185 bp |
| RefSeq ORF | 1983 bp |
| Locus ID | 23768 |
| UniProt ID | O43155 |
| Cytogenetics | 14q31.3 |
| Domains | FN3, LRR, LRRCT, LRRNT, LRR_TYP |
| Protein Families | Druggable Genome, Transmembrane |
| Summary | This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. provided by RefSeq, Sep 2016 Transcript Variant: This variant (3) uses an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Reviews
Documents
| Product Manuals |
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Resources
"NM_013231" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC224270 | FLRT2 (Myc-DDK-tagged)-Human fibronectin leucine rich transmembrane protein 2 (FLRT2) | 10 ug |
$614.00
|
|
| RC224270L1 | Lenti ORF clone of Human fibronectin leucine rich transmembrane protein 2 (FLRT2), Myc-DDK-tagged | 10 ug |
$914.00
|
|
| RC224270L2 | Lenti ORF clone of Human fibronectin leucine rich transmembrane protein 2 (FLRT2), mGFP tagged | 10 ug |
$914.00
|
|
| RC224270L3 | Lenti ORF clone of Human fibronectin leucine rich transmembrane protein 2 (FLRT2), Myc-DDK-tagged | 10 ug |
$914.00
|
|
| RC224270L4 | Lenti ORF clone of Human fibronectin leucine rich transmembrane protein 2 (FLRT2), mGFP tagged | 10 ug |
$914.00
|
|
| RG224270 | FLRT2 (tGFP-tagged) - Human fibronectin leucine rich transmembrane protein 2 (FLRT2) | 10 ug |
$489.00
$814.00
|
|
Citations
FLRT2 suppresses bladder cancer progression through inducing ferroptosis
Jiang, Ning, Yu et al
J Cell Mol Med (2023)
Jiang, Ning, Yu et al
J Cell Mol Med (2023)
Cited by 18
AI Summary: In this study, OriGene's FLRT2 overexpression lentiviral construct (#SC115333) was used to increase FLRT2 levels in bladder cancer cells, enabling the authors to investigate FLRT2's role in suppressing tumor progression through ferroptosis induction.
Snippet: … Fibronectin leucine rich transmembrane protein 2 (FLRT2) is associated with the regulation Save;To overexpress FLRT2, T24 and UMUC-3 cells were infected with lentivirus carrying FLRT2 (NM_013231, FLRT2 OE;#SC115333, OriGene) at a multiplicity of infection (MOI) of 30 or control (CTRL) plasmids for 6 h, and then cultured for an additional 72 h before harvested
Showing 1-1 of 1 papers.
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