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RAP1B (NM_015646) Human Untagged Clone

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SKU
SC114605
RAP1B (untagged)-Human RAP1B, member of RAS oncogene family (RAP1B), transcript variant 1
  $300.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol RAP1B
Synonyms K-REV; RAL1B
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC114605 sequence for NM_015646 edited (data generated by NextGen Sequencing)
ATGCGTGAGTATAAGCTAGTCGTTCTTGGCTCAGGAGGCGTTGGAAAGTCTGCTTTGACT
GTACAATTTGTTCAAGGAATTTTTGTAGAAAAATACGATCCTACGATAGAAGATTCTTAT
AGAAAGCAAGTTGAAGTAGATGCACAACAGTGTATGCTTGAAATCTTGGATACTGCAGGA
ACGGAGCAATTTACAGCAATGAGGGATTTATACATGAAAAATGGACAAGGATTTGCATTA
GTTTATTCCATCACAGCACAGTCCACATTTAACGATTTACAAGACCTGAGAGAACAGATT
CTTCGAGTTAAAGACACTGATGATGTTCCAATGATTCTTGTTGGTAATAAGTGTGACTTG
GAAGATGAAAGAGTTGTAGGGAAGGAACAAGGTCAAAATCTAGCAAGACAATGGAACAAC
TGTGCATTCTTAGAATCTTCTGCAAAATCAAAAATAAATGTTAATGAGATCTTTTATGAC
CTAGTGCGGCAAATTAACAGAAAAACTCCAGTGCCTGGGAAGGCTCGCAAAAAGTCATCA
TGTCAGCTGCTTTAA

Clone variation with respect to NM_015646.4
5' Read Nucleotide Sequence
>OriGene 5' read for NM_015646 unedited
GTCAGAATTTGTATACGACTCCTATAGGGCGGCCGCGATTCGGCACGAGGCCAGATTCAG
GCGTGTAAACCAGCCGGAGCGGCGCGGCAGCGGCAGGACCGCCGTGGCGCCTAGAGTAGC
GACCCGGGGGGAGCGCGGGGCGACGCTGGCTGCAGGGACCCGGTGACAGCGTGAGAGGTA
CTAGGTTTTGACAAGCTTGCATCATGCGTGAGTATAAGCTAGTCGTTCTTGGCTCAGGAG
GCGTTGGAAAGTCTGCTTTGACTGTACAATTTGTTCAAGGAATTTTTGTAGAAAAATACG
ATCCTACGATAGAAGATTCTTATAGAAAGCAAGTTGAAGTAGATGCACAACAGTGTATGC
TTGAAATCTTGGATACTGCAGGAACGGAGCAATTTACAGCAATGAGGGATTTATACATGA
AAAATGGACAAGGATTTGCATTAGTTTATTCCATCACAGCACAGTCCACATTTAACGATT
TACAAGACCTGAGAGAACAGATTCTTCGAGTTAAAGACACTGATGATGTTCCAATGATTC
TTGTTGGTAATAAGTGTGACTTGGAAGATGAAAGAGTTGTAGGGAAGGAACAAGGTCAAA
ATCTAGCAAGACAATGGAACAACTGTGCATTCTTAGAATCTTCTGCAAAATCAAAAATAA
ATGTTAATGAGATCTTTTATGACCTAGTGCGGCACATTAACAGANAAACTCCAGTGCCTG
GGAAGGCTCGCNAAAAGTCATCATGTCAGCTGCTTTAATATACTACATGCATTGTAGCTC
TGAGCCAGTTCTGAAAGACTGTTGCCCCATTCACAGTGCCAGCATTCCAACTTTGTTAAA
CCTACCAACATCCTAAATGGACTCTCCCTGTGGTGGTACCCTTTAGGAGGCGGATGAAAG
CTACATTATCAGTTTGCACATTCTAAT
3' Read Nucleotide Sequence
>OriGene 3' read for NM_015646 unedited
ACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCTTTTTTTTTTTTTTTT
TTGGCAAGTAATTATAATGCAAGCCCTTGCATGGCAATCCAAATTTATTGAACTACTGAT
GCTAAGTTATACAAAATTGCACCACTTTAATTAAGGCTTTTAGTTTACATTTGGCCACCT
CAAAGTAGTTGTAACATTAGGTTGGTCAATTTAAATACTGGGGCTCCCTGTTGGATAGAC
ACACAATCTTTACATCCAAACATTAATGCATACAAAGCAACAAGGCATTGTTAAATAAAA
CAGCAATAGTTACTGCAAATTAGGCCTTGTGACCAATTACATATGATTAAAATTACTTCC
CACATTCACATCCACAGTACTCGTCCACCATTTAACATCTCAACCAAAACGTTACACATG
TGAAACAATCACTAACAGGCAAAAATACTAAACCTGTATATTTGGTATTGCAAATACACT
TATGCATGAGCAAGCAAGGGATTCACAGTGAGAATCTACAGCTGCAGAAGCCTGAAAATG
ATTTACAAAAATTGTTAAATCATTAAAAAATTGTTTGAAAATATACACTTCTTGTTGTAG
ACCCCCACTGTACACACGACTATAAACATTGTTCCCTATGTAAACAAAAAAAGGAAACAT
ATAATAAGAGATTTGAAAAGTCTGGACATTTCCTTTCCAACAGATATTAAAGGCAACGTC
TTTAATCTAAGACATTATACTGAAAGGACTATCATGTTTTTAAGACCAGATCACCCGTCT
CACAGGTTTTTTTAAAATTAAAAAAACTTATAAGCTGTGGTAATCAAAGCGCTTATTTTT
GACAATAATAATGACCTTGAATTTCTTAAAAAAAATACAATAGCCTACAGTTTTAAAGAA
CGAAGTTTCCTGGATAGTCTTATAGGGAGCCTTTGCACTTTCTTTATTATGCAAC
Restriction Sites NotI-NotI |
ACCN NM_015646
Insert Size 2140 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_015646.4, NP_056461.1
RefSeq Size 2126 bp
RefSeq ORF 555 bp
Locus ID 5908
UniProt ID P61224
Cytogenetics 12q15
Domains RAB, RAN, ras, RAS, RHO
Protein Families Druggable Genome
Protein Pathways Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Long-term potentiation, MAPK signaling pathway, Neurotrophin signaling pathway, Renal cell carcinoma
Summary This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. provided by RefSeq, Oct 2011
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
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Documents
Resources
"NM_015646" in other vectors (6)
SKU Description Size Price
RC221678 RAP1B (Myc-DDK-tagged)-Human RAP1B, member of RAS oncogene family (RAP1B), transcript variant 1 10 ug
$300.00
RC221678L1 Lenti ORF clone of Human RAP1B, member of RAS oncogene family (RAP1B), transcript variant 1, Myc-DDK-tagged 10 ug
$600.00
RC221678L2 Lenti ORF clone of Human RAP1B, member of RAS oncogene family (RAP1B), transcript variant 1, mGFP tagged 10 ug
$600.00
RC221678L3 Lenti ORF clone of Human RAP1B, member of RAS oncogene family (RAP1B), transcript variant 1, Myc-DDK-tagged 10 ug
$600.00
RC221678L4 Lenti ORF clone of Human RAP1B, member of RAS oncogene family (RAP1B), transcript variant 1, mGFP tagged 10 ug
$600.00
RG221678 RAP1B (tGFP-tagged) - Human RAP1B, member of RAS oncogene family (RAP1B), transcript variant 1 10 ug
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file-alt Citations

Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers
Cheung, Du, Boehm et al
Cancer Discov (2011) 1 (7), 608-25 DOI: 10.1158/2159-8290.CD-11-0046
AI Summary: OriGene products, specifically the CRKL cDNA clone (OriGene, RC208446) and CRKL shRNA constructs (OriGene, TR316282), were used to overexpress and suppress CRKL in cell lines, enabling the authors to demonstrate CRKL’s role in promoting transformation and EGFR inhibitor resistance in non-small cell lung cancer.
FigureFigure
Showing 1-1 of 1 papers.
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