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EXOSC4 (NM_019037) Human Untagged Clone

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SKU
SC113302
EXOSC4 (untagged)-Human exosome component 4 (EXOSC4)
  $300.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol EXOSC4
Synonyms hRrp41p; p12A; RRP41; RRP41A; Rrp41p; SKI6; Ski6p
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC113302 sequence for NM_019037 edited (data generated by NextGen Sequencing)
ATGGCGGGGCTGGAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGCGGCGCGCCGGG
GAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCGCAGGCTGACGGCTCGGCCTAC
ATTGAGCAGGGCAACACCAAGGCACTGGCTGTGGTCTACGGCCCGCACGAGATCCGGGGC
TCCCGGGCTCGAGCCCTGCCGGACAGGGCCCTAGTGAACTGTCAATATAGTTCAGCGACC
TTCAGCACAGGTGAGCGCAAGCGACGGCCACATGGGGACCGTAAGTCCTGTGAGATGGGC
CTGCAGCTCCGCCAGACTTTCGAAGCAGCCATCCTCACACAGCTGCACCCACGCTCCCAG
ATTGATATCTATGTGCAGGTGCTACAGGCAGATGGTGGGACCTATGCAGCTTGTGTGAAT
GCAGCCACGCTGGCAGTGCTGGATGCCGGGATACCCATGAGAGACTTTGTGTGTGCGTGC
TCAGCTGGCTTCGTGGACGGCACAGCCCTGGCGGACCTCAGCCATGTGGAGGAAGCAGCT
GGTGGCCCCCAGCTGGCCCTGGCCCTGCTGCCAGCCTCAGGACAGATTGCGCTGCTTGAG
ATGGATGCCCGGCTGCACGAGGACCACCTGGAGCGGGTGTTGGAGGCTGCTGCCCAGGCT
GCCCGAGATGTGCACACCCTCTTAGATCGAGTGGTCCGGCAGCATGTGCGTGAGGCCTCT
ATCTTGCTGGGGGACTGA

Clone variation with respect to NM_019037.2
5' Read Nucleotide Sequence
>OriGene 5' read for NM_019037 unedited
GTGGATTTGTATCCGACTTCTATAGGCGGCCGCGCAATTCGCACGAGGGCGGACCTGGCG
GCCGGGCAGCATGGCGGGGCTGGCAGCTCTTGTCGGACCAGGGCTACCGGGTGGACGGGC
GGCGCGCCGGGGAGCTGCGCAAGATCCAGGCGCGGATGGGCGTGTTCGCGCAGGCTGACG
GCTCGGCCTACATTGAGCAGGGCAACACTTTGCACTGGCTGTGGTCTACGGCCCGCACGA
GATCCGGGGCTCCCGGGCTCGAGCCCTGCCGGACAGGGCCCTAGTGAACTGTCAATATAG
TTCAGCGACCTTCAGCACAGGTGAGCGCAAGCGACGGCCACATGGGGACCGTAAGTCCTG
TGAGATGGGCCTGCAGCTCCGCCAGACTTTCGAAGCAGCCATCCTCACACAGCTGCACCC
ACGCTCCCAGATTGATATCTATGTGCAGGTGCTACAGGCAGATGGTGGGACCTATGCAGC
TTGTGTGAATGCAGCCACGCTGGCAGTGCTGGATGCCGGGATACCCATGAGAGACTTTGT
GTGTGCGTGCTCAGCTGGCTTCGTGGACGGCACAGCCCTGGCGGACCTCAGCCATGTGGA
GGAAGCAGCTGGTGGCCCCCAGCTGGCCCTGGCCCTGCTGCCAGCCTCAGGACAGATTGC
GCTGCTTGAGATGGATGCCCGGCTGCACGAGGACCACCTGGAGCCGGTGTTTGGAGGCTG
CTGCCCAGGCTGCCCGAGATGTGCACACCCTCTTAGATCGAGTGGTCCCGCAGCATGTGC
GTGAAGCCTCTATTCTGCTGGGGACTGACCACCCACCACCCATGTCCAGAATAAACCCTT
CTCTGCCCCCAAAAAAGAAAAAAAAAAAAAAACTTGACTCTAGATTGGGCCGCGTCATAG
TTGTCCCTGAAAGATCCCGGTGGC
3' Read Nucleotide Sequence
>OriGene 3' read for NM_019037 unedited
GGCAACTTCCAGGGCCAGNANAGCACTGGGGAGGGGTCACAGGNATGCCACCCGGGATCT
GTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTT
TCTTTTTTTGGGGGCAGAGGAGGGTTTTATTCTGGACATGGGTGGCTGGGTGGTCAGTCC
CCCAGCAAGATAGAGGCCTCACGCACATGCTGCCGGACCACTCGATCTAAGAGGGTGTGC
ACATCTCGGGCAGCCTGGGCAGCAGCCTCCAACACCCGCTCCAGGTGGTCCTCGTGCAGC
CGGGCATCCATCTCAAGCAGCGCAATCTGTCCTGAGGCTGGCAGCAGGGCCAGGGCCAGC
TGGGGGCCACCAGCTGCTTCCTCCACATGGCTGAGGTCCGCCAGGGCTGTGCCGTCCACG
AAGCCAGCTGAGCACGCACACACAAAGTCTCTCATGGGTATCCCGGCATCCAGCACTGCC
AGCGTGGCTGCATTCACACAAGCTGCATAGGTCCCACCATCTGCCTGTAGCACCTGCACA
TAGATATCAATCTGGGAGCGTGGGTGCANCTGTGTGAGGATGGCTGCTTCNAAAGTCTGG
CGGAGCTGCAGGCCCATCTCACAGGACTTACGGTCCCCATGTGGCCGTCGCTTGCGCTCA
CCTGTGCTGANAGTCGCTGAACTATATTGACAGTTCACTANGGGCCCTGTCCGGCAGGGC
TCGAGCCCCGGAGCCCCGNTCTCGTGCGGGCCGTAAACACAGCCAGTGCCTTGTGTTGCC
CTGCTCATGTANGCCGGAGCCGTAGCCTGCGCGAACACGCCCATCCCGGGCTGGATNTTT
GGCAGNTCCCCGGNGCGCGNCCCTCCACCCGGTAGCCCTGGTCCAAA
Restriction Sites NotI-NotI |
ACCN NM_019037
Insert Size 860 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_019037.2, NP_061910.1
RefSeq Size 948 bp
RefSeq ORF 738 bp
Locus ID 54512
UniProt ID Q9NPD3
Cytogenetics 8q24.3
Domains RNase_PH_C
Protein Pathways RNA degradation
Summary Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.UniProtKB/Swiss-Prot Function
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"NM_019037" in other vectors (6)
SKU Description Size Price
RC201058 EXOSC4 (Myc-DDK-tagged)-Human exosome component 4 (EXOSC4) 10 ug
$300.00
RC201058L1 Lenti ORF clone of Human exosome component 4 (EXOSC4), Myc-DDK-tagged 10 ug
$600.00
RC201058L2 Lenti ORF clone of Human exosome component 4 (EXOSC4), mGFP tagged 10 ug
$600.00
RC201058L3 Lenti ORF clone of Human exosome component 4 (EXOSC4), Myc-DDK-tagged 10 ug
$600.00
RC201058L4 Lenti ORF clone of Human exosome component 4 (EXOSC4), mGFP tagged 10 ug
$600.00
RG201058 EXOSC4 (tGFP-tagged) - Human exosome component 4 (EXOSC4) 10 ug
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