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FOXM1 (NM_021953) Human Untagged Clone

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SKU
SC112825
FOXM1 (untagged)-Human forkhead box M1 (FOXM1), transcript variant 2
  $700.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol FOXM1
Synonyms FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11; HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29; TRIDENT
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC112825 sequence for NM_021953 edited (data generated by NextGen Sequencing)
ATGAAAACTAGCCCCCGTCGGCCACTGATTCTCAAAAGACGGAGGCTGCCCCTTCCTGTT
CAAAATGCCCCAAGTGAAACATCAGAGGAGGAACCTAAGAGATCCCCTGCCCAACAGGAG
TCTAATCAAGCAGAGGCCTCCAAGGAAGTGGCAGAGTCCAACTCTTGCAAGTTTCCAGCT
GGGATCAAGATTATTAACCACCCCACCATGCCCAACACGCAAGTAGTGGCCATCCCCAAC
AATGCTAATATTCACAGCATCATCACAGCACTGACTGCCAAGGGAAAAGAGAGTGGCAGT
AGTGGGCCCAACAAATTCATCCTCATCAGCTGTGGGGGAGCCCCAACTCAGCCTCCAGGA
CTCCGGCCTCAAACCCAAACCAGCTATGATGCCAAAAGGACAGAAGTGACCCTGGAGACC
TTGGGACCAAAACCTGCAGCTAGGGATGTGAATCTTCCTAGACCACCTGGAGCCCTTTGC
GAGCAGAAACGGGAGACCTGTGCAGATGGTGAGGCAGCAGGCTGCACTATCAACAATAGC
CTATCCAACATCCAGTGGCTTCGAAAGATGAGTTCTGATGGACTGGGCTCCCGCAGCATC
AAGCAAGAGATGGAGGAAAAGGAGAATTGTCACCTGGAGCAGCGACAGGTTAAGGTTGAG
GAGCCTTCGAGACCATCAGCGTCCTGGCAGAACTCTGTGTCTGAGCGGCCACCCTACTCT
TACATGGCCATGATACAATTCGCCATCAACAGCACTGAGAGGAAGCGCATGACTTTGAAA
GACATCTATACGTGGATTGAGGACCACTTTCCCTACTTTAAGCACATTGCCAAGCCAGGC
TGGAAGAACTCCATCCGCCACAACCTTTCCCTGCACGACATGTTTGTCCGGGAGACGTCT
GCCAATGGCAAGGTCTCCTTCTGGACCATTCACCCCAGTGCCAACCGCTACTTGACATTG
GACCAGGTGTTTAAGCCACTGGACCCAGGGTCTCCACAATTGCCCGAGCACTTGGAATCA
CAGCAGAAACGACCGAATCCAGAGCTCCGCCGGAACATGACCATCAAAACCGAACTCCCC
CTGGGCGCACGGCGGAAGATGAAGCCACTGCTACCACGGGTCAGCTCATACCTGGTACCT
ATCCAGTTCCCGGTGAACCAGTCACTGGTGTTGCAGCCCTCGGTGAAGGTGCCATTGCCC
CTGGCGGCTTCCCTCATGAGCTCAGAGCTTGCCCGCCATAGCAAGCGAGTCCGCATTGCC
CCCAAGGTGCTGCTAGCTGAGGAGGGGATAGCTCCTCTTTCTTCTGCAGGACCAGGGAAA
GAGGAGAAACTCCTGTTTGGAGAAGGGTTTTCTCCTTTGCTTCCAGTTCAGACTATCAAG
GAGGAAGAAATCCAGCCTGGGGAGGAAATGCCACACTTAGCGAGACCCATCAAAGTGGAG
AGCCCTCCCTTGGAAGAGTGGCCCTCCCCGGCCCCATCTTTCAAAGAGGAATCATCTCAC
TCCTGGGAGGATTCGTCCCAATCTCCCACCCCAAGACCCAAGAAGTCCTACAGTGGGCTT
AGGTCCCCAACCCGGTGTGTCTCGGAAATGCTTGTGATTCAACACAGGGAGAGGAGGGAG
AGGAGCCGGTCTCGGAGGAAACAGCATCTACTGCCTCCCTGTGTGGATGAGCCGGAGCTG
CTCTTCTCAGAGGGGCCCAGTACTTCCCGCTGGGCCGCAGAGCTCCCGTTCCCAGCAGAC
TCCTCTGACCCTGCCTCCCAGCTCAGCTACTCCCAGGAAGTGGGAGGACCTTTTAAGACA
CCCATTAAGGAAACGCTGCCCATCTCCTCCACCCCGAGCAAATCTGTCCTCCCCAGAACC
CCTGAATCCTGGAGGCTCACGCCCCCAGCCAAAGTAGGGGGACTGGATTTCAGCCCAGTA
CAAACCTCCCAGGGTGCCTCTGACCCCTTGCCTGACCCCCTGGGGCTGATGGATCTCAGC
ACCACTCCCTTGCAAAGTGCTCCCCCCCTTGAATCACCGCAAAGGCTCCTCAGTTCAGAA
CCCTTAGACCTCATCTCCGTCCCCTTTGGCAACTCTTCTCCCTCAGATATAGACGTCCCC
AAGCCAGGCTCCCCGGAGCCACAGGTTTCTGGCCTTGCAGCCAATCGTTCTCTGACAGAA
GGCCTGGTCCTGGACACAATGAATGACAGCCTCAGCAAGATCCTGCTGGACATCAGCTTT
CCTGGCCTGGACGAGGACCCACTGGGCCCTGACAACATCAACTGGTCCCAGTTTATTCCT
GAGCTACAGTAG

Clone variation with respect to NM_021953.3
5' Read Nucleotide Sequence
>OriGene 5' read for NM_021953 unedited
GTGTACCATTTTGTAATACAACTCACTATAGGCGGCCGCGAAATTCGCACGAGGGGTCCA
CACTTGTGATTCTCAATGGAGAGTGAAAACGCAGATTCATAATGAAAACTAGCCCCCGTC
GGCCACTGATTCTCAAAAGACGGAGGCTGCCCCTTCCTGTTCAAAATGCCCCAAGTGAAA
CATCAGAGGAGGAACCTAAGAGATCCCCTGCCCAACAGGAGTCTAATCAAGCAGAGGCCT
CCAAGGAAGTGGCAGAGTCCAACTCTTGCAAGTTTCCAGCTGGGATCAAGATTATTAACC
ACCCCACCATGCCCAACACGCAAGTAGTGGCCATCCCCAACAATGCTAATATTCACAGCA
TCATCACAGCACTGACTGCCAAGGGAAAAGAGAGTGGCAGTACTGGGCCCAACAAATTCA
TCCTCATCACCTGTGGGGGAGCCCCAACTCAGCCTCCAGGACTCCGGCCTCAAACCCAAA
CCAGCTATGATGCCAAAAGGACAGAAGTGACCCTGGAGACCTTGGGACCAAAACCTGCAG
CTAGGGATGTGAATCTTCCTAGACCACCTGTAGCCCTTTGCGAGCAGAAACGGGAGACCT
GTGCAGATGGTGAGGCACCAGGCTGCACTATCAACAATAGCCTATTCCACATCCAGTGGC
CTTCGAAAGATGAGTCCTGATGGCCTGGGCCTCCCCAGCATCAAGCCAGAGATGGAGGGA
AAGGAAAATTTGTCACCTCGGGCACACCACAGGTTAAGGTTGAAGAGCCTTCCGAAACCT
CATCGTCCCGGAACAACCCTGTGTCTCGACGGACACCTCACTCTTACATGGGCATGAAAC
CAATCGCCATCAACCCCATTGATAAGAAGCCCATGCACTTTGAAAACATCTATACGTCGC
ATTGAGGACCCTCTTCCTTACTTAACCCCTTTGCCAGCCAC
3' Read Nucleotide Sequence
>OriGene 3' read for NM_021953 unedited
AATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGCATGTCCACCTTCGCTTTTATTGAGTA
GTTAGTGTTCTCAAGCTGGCTCACACCCATGCGGTCAGCTGGGGCCTAGGGTGGCTCTTT
GCAAAGCTGAGGGGCAAGCTAAGGAAGCCAGGCAGGTCAGGGGCCCTTTCGGCCTTCTCA
AGCCTCCACCTGAGTTCTCGTCAATGCCAGTCTCCCTGGTATGATTGGGGACATTATCAG
AGAAACATCTAATAGCGCACATCTGGGCACCCACACTCTGCTTCAGTTGCATCCATCCTC
CCACCCCAAATTCAACTCCTGACCCAATACAAAAGACTTTTTTAACCAGGATTTCTTCTT
GCAGGAAAGCTGACTTGGAAACACGGGGAGGTGGCAGGGAGGGGCAAAAAGGACTCTGGC
AAGCAGATCCACTTGTCTGGGTCCCTGCAGTGAAGAACCCAAGATCCAGGTACCTCAGCC
TGGAAGAAACCGTGCACTGCAGGTCTTCCCTTCTATCAAAACTAAAAGCAAGGAACAGAA
GTCAATTGAAACCCCAGGTCATCCTACCCACCTTCTGGCAGTCTCTGGATAATGATCTAA
GGAAATAAGCTTACATTTATAATTAGAGGATAATTTGGAGAATTTATACTATTTACACGG
ACCACNCCTGCAAGATCAGGNAAGGGTAGAGACTGCTGGGCAGAGAATGGAAACAGGCTG
GAGGGNTCCTAATCTCTTTTACCATTGGCTTAGTAGNTCCACCCCNCAGCTTCTGGCAGG
GACAGCAGATGAATCAGATACTCCTGGGGAACACAAAGTCCCANCAGTGGCTATGGTGTG
ACTGCTACTTTTGCATATCCAGGCACCAAGGAGCTATGAGGAGCANAANCAGTCCTGGCC
TGCTGCCCTCACTCAAAGGCTCGGGNTGACCTGAGCCTTGGATGCCCCGGATGTTGGCAG
CTTGNCCAAGGGCAAGCCAGGCCTTACTGACTCAGGATAACTGGACANNTGAGTGTCAGG
CCCAAGGGTCCTTCC
Restriction Sites ECoRI-NOT |
ACCN NM_021953
Insert Size 3460 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_021953.2, NP_068772.2
RefSeq Size 3527 bp
RefSeq ORF 2292 bp
Locus ID 2305
UniProt ID Q08050
Cytogenetics 12p13.33
Domains FH
Protein Families Transcription Factors
Summary The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2011
Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
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Documents
Resources
"NM_021953" in other vectors (7)
SKU Description Size Price
RC202246 FOXM1 (Myc-DDK-tagged)-Human forkhead box M1 (FOXM1), transcript variant 2 10 ug
$699.00
RC202246L1 Lenti ORF clone of Human forkhead box M1 (FOXM1), transcript variant 2, Myc-DDK-tagged 10 ug
$999.00
RC202246L2 Lenti ORF clone of Human forkhead box M1 (FOXM1), transcript variant 2, mGFP tagged 10 ug
$999.00
RC202246L3 Lenti ORF clone of Human forkhead box M1 (FOXM1), transcript variant 2, Myc-DDK-tagged 10 ug
$999.00
RC202246L4 Lenti ORF clone of Human forkhead box M1 (FOXM1), transcript variant 2, mGFP tagged 10 ug
$999.00
RG202246 FOXM1 (tGFP-tagged) - Human forkhead box M1 (FOXM1), transcript variant 2 10 ug
$789.00 $899.00
SC323762 FOXM1 (untagged)-Human forkhead box M1 (FOXM1), transcript variant 2 10 ug
$700.00

file-alt Citations

Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression
Barger, Zhang, Hillman et al
Oncotarget (2015) 6 (29), 27613-27 DOI: 10.18632/oncotarget.4546
Cited by 93
AI Summary: In this study, OriGene products—specifically the FOXM1 cDNA clone (RC208447) and FOXM1 shRNA (TL312204)—were used to manipulate FOXM1 expression in ovarian cancer cell models, enabling the authors to investigate FOXM1’s role in cell cycle progression and its genetic regulation in epithelial ovarian cancer.
FigureFigureFigure
A FOXM1 Dependent Mesenchymal-Epithelial Transition in Retinal Pigment Epithelium Cells
Choudhary, Dodsworth, Sidders et al
PLoS ONE (2015) 10 (6), e0130379 DOI: 10.1371/journal.pone.0130379
Cited by 14
AI Summary: OriGene's FOXM1 overexpression vector (catalog number SC112825) was used to increase FOXM1 levels in retinal pigment epithelium cells, enabling the study of FOXM1's role in mesenchymal-epithelial transition and epithelial fate acquisition.
Snippet: The FOXM1 overexpression vector was purchased from Origene (SC112825) and transfected into RPE using the Effectene reagent (Qiagen) according to manufacturer's instructions, although some effects of reagent toxicity were noted. ... Cite SaveSaving
FigureFigureFigure
Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition
Gormally, Dexheimer, Marsico et al
Nat Commun (2014) 5, 5165 DOI: 10.1038/ncomms6165
Cited by 231
AI Summary: OriGene products, specifically the human full-length FOXM1c cDNA and the pEX-N-GST vector, were used to clone and express the FOXM1 DNA-binding domain for subsequent functional studies in this paper.
Snippet: ​FOXM1–DBD complementary DNA was cloned from the human full-length ​FOXM1c cDNA fragment (Origene Technologies). After PCR amplification with primers containing Sgf1 and MluI restriction sites, the products were gel purified and ligated in frame to the amino terminus of GST into the linear pEX-N-GST vector (Origene Technologies) containing a T7 promoter
FOXM1 and androgen receptor co-regulate CDC6 gene transcription and DNA replication in prostate cancer cells
Liu, Gong, Sun et al
Biochim. Biophys. Acta (2014) 1839 (4), 297-305 DOI: 10.1016/j.bbagrm.2014.02.016
Cited by 46
AI Summary: OriGene products contributed to this study by providing the FOXM1, AR, and CDC6 cDNAs in the pCMV-XL5 vector, which were used for overexpression experiments to investigate the regulation of CDC6 transcription in prostate cancer cells.
Snippet: HEK 293T cells were maintained in Dulbecco's Modified Eagle Medium (DMEM) supplemented with 10% FBS and 1% penicillin/streptomycin. 2.2. Plasmids and siRNA. FOXM1, AR and CDC6 cDNAs in the pCMV-XL5 vector were purchased from Origene (Rockville ... Cite SaveSaving
FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma
Bellelli, Castellone, Garcia-Rostan et al
Endocr. Relat. Cancer (2012) 19 (5), 695-710 DOI: 10.1530/ERC-12-0031
Cited by 4
AI Summary: OriGene Technologies contributed to this study by providing the HA-FOXM1b plasmid, which was used to investigate the role of FOXM1 in anaplastic thyroid carcinoma.
Snippet: All the cells were DNA profiled by short tandem repeat analysis and shown to be unique and identical to those reported in Schweppe et al. ... The HA-FOXM1b plasmid was purchased from Origene Technologies (Rockville, MD, USA);HA-FOXM1c was a kind gift of Dr KM Yao
Down-regulation of Forkhead Box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells
Wang, Banerjee, Kong et al
Cancer Res (2007) 67 (17), 8293-300 DOI: 10.1158/0008-5472.CAN-07-1265
AI Summary: In this study, OriGene's FoxM1 small interfering RNA (siRNA) was used to down-regulate FoxM1 expression in pancreatic cancer cells, enabling the researchers to demonstrate that FoxM1 inhibition suppresses cell growth, invasion, and angiogenesis.
Showing 1-6 of 6 papers.
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