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AXL (NM_021913) Human Untagged Clone

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SKU
SC112559
AXL (untagged)-Human AXL receptor tyrosine kinase (AXL), transcript variant 1
  $819.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol AXL
Synonyms ARK; JTK11; Tyro7; UFO
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_021913 edited
GGCGGCTGCTGGGCAGAGCCGGTGGCAAGGGCCTCCCCTGCCGCTGTGCCAGGCAGGCAG
TGCCAAATCCGGGGAGCCTGGAGCTGGGGGGAGGGCCGGGGACAGCCCGGCCCTGCCCCC
TCCCCCGCTGGGAGCCCAGCAACTTCTGAGGAAAGTTTGGCACCCATGGCGTGGCGGTGC
CCCAGGATGGGCAGGGTCCCGCTGGCCTGGTGCTTGGCGCTGTGCGGCTGGGCGTGCATG
GCCCCCAGGGGCACGCAGGCTGAAGAAAGTCCCTTCGTGGGCAACCCAGGGAATATCACA
GGTGCCCGGGGACTCACGGGCACCCTTCGGTGTCAGCTCCAGGTTCAGGGAGAGCCCCCC
GAGGTACATTGGCTTCGGGATGGACAGATCCTGGAGCTCGCGGACAGCACCCAGACCCAG
GTGCCCCTGGGTGAGGATGAACAGGATGACTGGATAGTGGTCAGCCAGCTCAGAATCACC
TCCCTGCAGCTTTCCGACACGGGACAGTACCAGTGTTTGGTGTTTCTGGGACATCAGACC
TTCGTGTCCCAGCCTGGCTATGTTGGGCTGGAGGGCTTGCCTTACTTCCTGGAGGAGCCC
GAAGACAGGACTGTGGCCGCCAACACCCCCTTCAACCTGAGCTGCCAAGCTCAGGGACCC
CCAGAGCCCGTGGACCTACTCTGGCTCCAGGATGCTGTCCCCCTGGCCACGGCTCCAGGT
CACGGCCCCCAGCGCAGCCTGCATGTTCCAGGGCTGAACAAGACATCCTCTTTCTCCTGC
GAAGCCCATAACGCCAAGGGGGTCACCACATCCCGCACAGCCACCATCACAGTGCTCCCC
CAGCAGCCCCGTAACCTCCACCTGGTCTCCCGCCAACCCACGGAGCTGGAGGTGGCTTGG
ACTCCAGGCCTGAGCGGCATCTACCCCCTGACCCACTGCACCCTGCAGGCTGTGCTGTCA
GACGATGGGATGGGCATCCAGGCGGGAGAACCAGACCCCCCAGAGGAGCCCCTCACCTCG
CAAGCATCCGTGCCCCCCCATCAGCTTCGGCTAGGCAGCCTCCATCCTCACACCCCTTAT
CACATCCGCGTGGCATGCACCAGCAGCCAGGGCCCCTCATCCTGGACCCACTGGCTTCCT
GTGGAGACGCCGGAGGGAGTGCCCCTGGGCCCCCCTGAGAACATTAGTGCTACGCGGAAT
GGGAGCCAGGCCTTCGTGCATTGGCAAGAGCCCCGGGCGCCCCTGCAGGGTACCCTGTTA
GGGTACCGGCTGGCGTATCAAGGCCAGGACACCCCAGAGGTGCTAATGGACATAGGGCTA
AGGCAAGAGGTGACCCTGGAGCTGCAGGGGGACGGGTCTGTGTCCAATCTGACAGTGTGT
GTGGCAGCCTACACTGCTGCTGGGGATGGACCCTGGAGCCTCCCAGTACCCCTGGAGGCC
TGGCGCCCAGGGCAAGCACAGCCAGTCCACCAGCTGGTGAAGGAACCTTCAACTCCTGCC
TTCTCGTGGCCCTGGTGGTATGTACTGCTAGGAGCAGTCGTGGCCGCTGCCTGTGTCCTC
ATCTTGGCTCTCTTCCTTGTCCACCGGCGAAAGAAGGAGACCCGTTATGGAGAAGTGTTT
GAACCAACAGTGGAAAGAGGTGAACTGGTAGTCAGGTACCGCGTGCGCAAGTCCTACAGT
CGTCGGACCACTGAAGCTACCTTGAACAGCTTGGGCATCAGTGAAGAGCTGAAGGAGAAG
CTGCGGGATGTGATGGTGGACCGGCACAAGGTGGCCCTGGGGAAGACTCTGGGAGAGGGA
GAGTTTGGAGCTGTGATGGAAGGCCAGCTCAACCAGGACGACTCCATCCTCAAGGTGGCT
GTGAAGACGATGAAGATTGCCATCTGCACGAGGTCAGAGCTGGAGGATTTCCTGAGTGAA
GCGGTCTGCATGAAGGAATTTGACCATCCCAACGTCATGAGGCTCATCGGTGTCTGTTTC
CAGGGTTCTGAACGAGAGAGCTTCCCAGCACCTGTGGTCATCTTACCTTTCATGAAACAT
GGAGACCTACACAGCTTCCTCCTCTATTCCCGGCTCGGGGACCAGCCAGTGTACCTGCCC
ACTCAGATGCTAGTGAAGTTCATGGCAGACATCGCCAGTGGCATGGAGTATCTGAGTACC
AAGAGATTCATACACCGGGACCTGGCGGCCAGGAACTGCATGCTGAATGAGAACATGTCC
GTGTGTGTGGCGGACTTCGGGCTCTCCAAGAAGATCTACAATGGGGACTACTACCGCCAG
GGACGTATCGCCAAGATGCCAGTCAAGTGGATTGCCATTGAGAGTCTAGCTGACCGTGTC
TACACCAGCAAGAGCGATGTGTGGTCCTTCGGGGTGACAATGTGGGAGATTGCCACAAGA
GGCCAAACCCCATATCCGGGCGTGGAGAACAGCGAGATTTATGACTATCTGCGCCGGGGA
AATCGCCTGAAGCAGCCTGCGGACTGTCTGGATGGACTGTATGCCTTGATGTCGCGGTGC
TGGGAGCTAAATCCCCAGGACCGGCCAAGTTTTACAGAGCTGCGGGAAGATTTGGAGAAC
ACACTGAAGGCCTTGCCTCCTGCCCAGGAGCCTGACGAAATCCTCTATGTCAACATGGAT
GAGGGTGGAGGTTATCCTGAACCCCCTGGAGCTGCAGGAGGAGCTGACCCCCCAACCCAG
CCAGACCCTAAGGATTCCTGTAGCTGCCTCACTGCGGCTGAGGTCCATCCTGCTGGACGC
TATGTCCTCTGCCCTTCCACAACCCCTAGCCCCGCTCAGCCTGCTGATAGGGGCTCCCCA
GCAGCCCCAGGGCAGGAGGATGGTGCCTGAGACAACCCTCCACCTGGTACTCCCTCTCAG
GATCCAAGCTAAGCACTGCCACTGGGGAAAACTCCACCTTCCCACTTTCCCACCCCACGC
CTTATCCCCACTTGCAGCCCTGTCTTCCTACCTATCCCACCTCCATCCCAGACAGGTCCC
TCCCCTTCTCTGTGCAGTAGCATCACCTTGAAAGCAGTAGCATCACCATCTGTAAAAGGA
AGGGGTTGGATTGCAATATCTGAAGCCCTCCCAGGTGTTAACATTCCAAGACTCTAGAGT
CCAAGGTTTAAAGAGTCTAGATTCAAAGGTTCTAGGTTTCAAAGATGCTGTGAGTCTTTG
GTTCTAAGGACCTGAAATTCCAAAGTCTCTAATTCTATTAAAGTGCTAAGGTTCTAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
5' Read Nucleotide Sequence
>OriGene 5' read for NM_021913 unedited
GTCAACATTTNGTAAACGACTTACTATAGGGCGGCCGCGAAATTCCCGGATGGCGGCTGC
TGGGCAGAGCCGGTGGCAAGGGCCTCCCCTGCCGCTGTGCCAAGCAGGCAGTGCCAAATC
CGGGGAGCCTGGAGCTGGGGGGAGGAAAAAAGCCATCACTCAAAGTGCACCACACATAAC
CCATAAATGAAAAAGAATAAACACAAAAAACTTATATCTTCTAAACAAAATACCACAAAT
TTTCGAGGGGAAAAACATCACAAAACCCAAACCACACCACATCCATTAAAAAGAAAATAT
TACTCCAATATATTAAAACAAAATCACAAAAAACAGCAACAAAACAAGACACAAATATAT
AACTAAAATAACACAATAAACAATTAAACACACAAATACATAAAACAAATACACCCCCTA
CAACAACACAGACACAGCCAAAAAAAAAACAATATGAAATACAAAAAAAACATAAAGAAC
ATAAGCTAACTAAACAAATAAAAGAAAAGAAAAACCGACAATTTCATCAAAAAAAATAAC
AAAAAAAACGAAACACAAACAAATATACAACCCACACACACAAAAAACCAAAAACTACTC
ACAAAAAAAAAACAAACAAAAGAAACATCCAACCACAGAACCATCAAGTATATAAAATAA
ACAACTTTATAACACAACCAACATCAATAGACATAACACCAAAAAAATTAAATAATCAAA
GAAAAACAACAACAATCAAATTCCCACTCCAGCAACGAAAAGATTAACTAAACCAACAAC
AAAACAAGACGTAAAATACAATAAAACAAAAAACTAAACAAATAGAAAAAAAAAATAAAT
CATATAAATTACAAATGTCCAAAAACTGATCACAAACGATAAAACTCAACATAACCATAA
ACAACACCACCAAAACAATAACAAACACTTCACACACTAACAACCAAATAAATAACAAAC
AAGTC
Restriction Sites Please inquire |
ACCN NM_021913
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_021913.2, NP_068713.2
RefSeq Size 4750 bp
RefSeq ORF 2685 bp
Locus ID 558
UniProt ID P30530
Cytogenetics 19q13.2
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Summary The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. provided by RefSeq, Jul 2013
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
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Documents
Resources
"NM_021913" in other vectors (8)
SKU Description Size Price
RC206431 AXL (Myc-DDK-tagged)-Human AXL receptor tyrosine kinase (AXL), transcript variant 1 10 ug
$819.00
RC206431L1 Lenti ORF clone of Human AXL receptor tyrosine kinase (AXL), transcript variant 1, Myc-DDK-tagged 10 ug
$1,119.00
RC206431L2 Lenti ORF clone of Human AXL receptor tyrosine kinase (AXL), transcript variant 1, mGFP tagged 10 ug
$1,119.00
RC206431L3 Lenti ORF clone of Human AXL receptor tyrosine kinase (AXL), transcript variant 1, Myc-DDK-tagged 10 ug
$1,119.00
RC206431L4 Lenti ORF clone of Human AXL receptor tyrosine kinase (AXL), transcript variant 1, mGFP tagged 10 ug
$1,119.00
RC600072 AXL (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens AXL receptor tyrosine kinase, transcript variant 1, Signal peptide (1-25) plus EC domain (26-451) 10 ug
$289.00 $457.00
RG206431 AXL (tGFP-tagged) - Human AXL receptor tyrosine kinase (AXL), transcript variant 1 10 ug
$789.00 $1,019.00
SC323559 AXL (untagged)-Kinase deficient mutant (K567M) of Human AXL receptor tyrosine kinase (AXL), transcript variant 1 10 ug
$819.00

file-alt Citations

Engineered AXL-ECD-Fc variants that abolish the AXL/Gas6 interaction suppress tumor cell migration
Duan, Hu, Qiao et al
Oncol Lett (2019) 17 (6), 5784-5792 DOI: 10.3892/ol.2019.10255
AI Summary: OriGene’s human full-length pCMV6-AXL plasmid (catalog no. SC112559) was used in this study to express AXL protein for investigating the effects of engineered AXL-ECD-Fc variants on tumor cell migration and the AXL/Gas6 interaction.
Snippet: Reagents and antibodies Recombinant Gas6 human protein (catalog no. 885-GSB) and goat anti-AXL antibodies (catalog no. … ab6737;Abcam, Cambridge, UK), human full-length pCMV6-AXL plasmid (catalog no. SC112559;OriGene Technologies, Inc., Rockville, MD, USA), TMB Chromogen Solution (catalog no. 183657000;Invitrogen;Thermo Fisher Scientific, Inc., Waltham, MA, USA), RIPA (catalog no. …
ELISA
Engineered AXL‑ECD‑Fc variants that abolish the AXL/Gas6 interaction suppress tumor cell migration
Duan, Hu, Qiao et al
Oncol Lett (2019)
AI Summary: OriGene’s human full-length pCMV6-AXL plasmid (catalog no. SC112559) was used in this study to express AXL protein, enabling the investigation of engineered AXL‑ECD‑Fc variants and their effects on tumor cell migration.
Snippet: catalog no. ab6737;Abcam, Cambridge, UK), human full-length pCMV6-AXL plasmid (catalog no. SC112559;OriGene Technologies, Inc., Rockville, MD, USA), TMB Chromogen Solution (catalog no. 183657000;Invitrogen
Aptamer-miR-34c Conjugate Affects Cell Proliferation of Non-Small-Cell Lung Cancer Cells
Russo, Paciocco, Affinito et al
Mol Ther Nucleic Acids (2018) 13, 334-346 DOI: 10.1016/j.omtn.2018.09.016
AI Summary: In this study, the OriGene AXL cDNA TruClone was used to transiently overexpress the AXL receptor in non-small-cell lung cancer cells, enabling the authors to assess the effects of miR-34c and the GL21.T/miR-34c chimera on cell proliferation and AXL-mediated resistance.
Snippet: …For transient overexpression of AXL cDNA TruClone (4 μg, final concentration) (Origene, Rockville, MD, USA), or 3′ UTR AXL plasmid (InvivoGen), cells were transfected using Lipofectamine 2000 (Invitrogen, Life Technologies, Monza, MB, Italy), according to the manufacturer’s;;a final concentration of 50 nM (Santa Cruz Biotechnologies, DBA ITALIA srl, Segrate (MI)- Italy). For transient overexpression of AXL cDNA TruClone (4 µg, final concentration) (Origene, Rockville, MD, USA), or 3' UTR AXL plasmid (InvivoGen), cells were transfected
FigureFigureFigure
Aptamer-miRNA-212 Conjugate Sensitizes NSCLC Cells to TRAIL
Iaboni, Russo, Fontanella et al
Mol Ther Nucleic Acids (2016) 5 (3), e289 DOI: 10.1038/mtna.2016.5
Cited by 71
AI Summary: In this study, OriGene products including anti-PED/PEA-15 antibody (TA500053) and PED/PEA-15 cDNA clone (RC215445) were used to assess the expression and functional role of PED/PEA-15 in NSCLC cells, helping to demonstrate that the aptamer-miR-212 conjugate sensitizes these cells to TRAIL therapy.
FigureFigureFigure
Functional Consequences of AXL Sequence Variants in Idiopathic Hypogonadotropic Hypogonadism
Salian-Mehta, Xu, Knox et al
J. Clin. Endocrinol. Metab. (2014)
Cited by 34
AI Summary: OriGene’s pCMV6-XL5-hAXL human AXL full-length plasmid was used to generate wild-type and mutant AXL constructs for functional assays, enabling the study of the effects of AXL sequence variants on neuronal migration and receptor processing in this paper.
Snippet: Vaginal smears were collected daily until estrus, stained with Toluidine Blue. Plasmids Human AXL full length plasmid pCMV6-XL5-hAXL was purchased (OriGene). WT and Mutant-hAXL constructs were made as described in supplementary section. ... Cite SaveSaving
AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma
Xu, Chan, Liu et al
Oncogene (2011) 30 (10), 1229-40 DOI: 10.1038/onc.2010.504
Cited by 231
AI Summary: In this study, OriGene products, specifically the human AXL shRNA (OriGene, Cat# TL313431) and AXL cDNA (OriGene, Cat# SC322835), were used to manipulate AXL expression in hepatocyte and HCC cell lines, enabling the authors to demonstrate that AXL mediates YAP-dependent oncogenic functions in hepatocellular carcinoma.
FigureFigure
Showing 1-6 of 6 papers.
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