Integrin beta 1 (ITGB1) (NM_002211) Human Untagged Clone
SKU
SC111935
ITGB1 (untagged)-Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A
$1,097.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | Integrin beta 1 |
| Synonyms | CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA; VLAB |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_002211 |
| Insert Size | 3800 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_002211.2, NP_002202.2 |
| RefSeq Size | 3700 bp |
| RefSeq ORF | 2397 bp |
| Locus ID | 3688 |
| UniProt ID | P05556 |
| Cytogenetics | 10p11.22 |
| Domains | INB, PSI |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Axon guidance, Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer |
| Summary | Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. provided by RefSeq, Jul 2008 Transcript Variant: This variant (1A) represents the longest transcript and encodes the shorter isoform (1A). Both variants 1A and 1E encode the same isoform. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_002211" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC203818 | ITGB1 (Myc-DDK-tagged)-Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A | 10 ug |
$731.00
|
|
| RC203818L1 | Lenti ORF clone of Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A, Myc-DDK-tagged | 10 ug |
$1,031.00
|
|
| RC203818L2 | Lenti ORF clone of Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A, mGFP tagged | 10 ug |
$1,031.00
|
|
| RC203818L3 | Lenti ORF clone of Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A, Myc-DDK-tagged | 10 ug |
$1,031.00
|
|
| RC203818L4 | Lenti ORF clone of Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A, mGFP tagged | 10 ug |
$1,031.00
|
|
| RG203818 | ITGB1 (tGFP-tagged) - Human integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A | 10 ug |
$789.00
$931.00
|
|
Citations
Twist induces epithelial-mesenchymal transition and cell motility in breast cancer via ITGB1-FAK/ILK signaling axis and its associated downstream network
Yang, Hou, Zhou et al
Int. J. Biochem. Cell Biol. (2015) 71, 62-71 DOI: 10.1016/j.biocel.2015.12.004
Yang, Hou, Zhou et al
Int. J. Biochem. Cell Biol. (2015) 71, 62-71 DOI: 10.1016/j.biocel.2015.12.004
Cited by 92
Gln362 of Angiopoietin-2 Mediates Migration of Tumor and Endothelial Cells through Association with α5β1 Integrin
Lee, Oh, Lee et al
J. Biol. Chem. (2014)
Lee, Oh, Lee et al
J. Biol. Chem. (2014)
AI Summary: OriGene contributed to this study by providing human α5 and β1 integrin cDNAs, which were used to investigate the molecular interaction between Angiopoietin-2 and α5β1 integrin.
Snippet: Inc., Santa Clara, CA). Human α5 and β1 integrin cDNAs were purchased from Origene and open reading frames of integrins were amplified by PCR and cloned into the pcDNA3.1 vector (Life Technologies). Human Ang-1 cDNA ... Cite SaveSaving
Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin
Staunstrup, Madsen, Primo et al
PLoS ONE (2012) 7 (5), e36658 DOI: 10.1371/journal.pone.0036658
Staunstrup, Madsen, Primo et al
PLoS ONE (2012) 7 (5), e36658 DOI: 10.1371/journal.pone.0036658
Cited by 40
AI Summary: In this study, OriGene’s human ITGB1 (Cat# SC119275) and ITGA2 (Cat# SC119274) cDNA clones were used to generate transgenic minipigs expressing human β1 and α2 integrins, enabling the creation of novel pig models for investigating skin inflammation.
SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways
Steinberg, Heesom, Bass et al
J. Cell Biol. (2012) 197 (2), 219-30 DOI: 10.1083/jcb.201111121
Steinberg, Heesom, Bass et al
J. Cell Biol. (2012) 197 (2), 219-30 DOI: 10.1083/jcb.201111121
Cited by 214
AI Summary: OriGene’s human Itgβ1 cDNA clone was used in this study to express wild-type and mutant integrin β1 proteins, enabling the authors to investigate how SNX17 regulates integrin stability and trafficking.
Snippet: Viral expression of GFP-tagged Rab proteins and human Itgβ1. The human Itgβ1 cDNA clone was obtained from OriGene and subcloned into pcDNA 3.1 using a primer for the wild-type protein as well as one with the Y795A mutation.
Showing 1-5 of 5 papers.
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