CBARA1 (MICU1) (NM_006077) Human Untagged Clone
SKU
SC111147
MICU1 (untagged)-Human calcium binding atopy-related autoantigen 1 (CBARA1), nuclear gene encoding mitochondrial protein, transcript variant 1
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | CBARA1 |
| Synonyms | ara CALC; CALC; CBARA1; EFHA3; MPXPS |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_006077 |
| Insert Size | 2500 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_006077.1, NP_006068.1 |
| RefSeq Size | 2387 bp |
| RefSeq ORF | 1437 bp |
| Locus ID | 10367 |
| UniProt ID | Q9BPX6 |
| Cytogenetics | 10q22.1 |
| Domains | EFh |
| Summary | This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. provided by RefSeq, Mar 2013 Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_006077" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC200921 | MICU1 (Myc-DDK-tagged)-Human calcium binding atopy-related autoantigen 1 (CBARA1), nuclear gene encoding mitochondrial protein, transcript variant 1 | 10 ug |
$289.00
$457.00
|
|
| RC200921L1 | Lenti ORF clone of Human calcium binding atopy-related autoantigen 1 (CBARA1), nuclear gene encoding mitochondrial protein, transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC200921L2 | Lenti ORF clone of Human calcium binding atopy-related autoantigen 1 (CBARA1), nuclear gene encoding mitochondrial protein, transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RC200921L3 | Lenti ORF clone of Human calcium binding atopy-related autoantigen 1 (CBARA1), nuclear gene encoding mitochondrial protein, transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC200921L4 | Lenti ORF clone of Human calcium binding atopy-related autoantigen 1 (CBARA1), nuclear gene encoding mitochondrial protein, transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RG200921 | MICU1 (tGFP-tagged) - Human calcium binding atopy-related autoantigen 1 (CBARA1), nuclear gene encoding mitochondrial protein, transcript variant 1 | 10 ug |
$489.00
$657.00
|
|
Citations
High-throughput screen identifies a potent MCU activator boosting cardiac contractile bioenergetics
Caldero-Escudero, Federico, Sánchez-González et al
bioRxiv (2026)
Caldero-Escudero, Federico, Sánchez-González et al
bioRxiv (2026)
AI Summary: OriGene contributed to the study by providing the human MICU1 cDNA template plasmid (catalog #SC111147), which was used for site-directed mutagenesis to investigate the molecular mechanism of MCU activation by CGP7930.
Snippet: Site-directed mutagenesis of MICU1 was performed using the QuikChange lightning (Agilent, #210519) mutagenesis kit according to the manufacturer’s instructions. The human MICU1 cDNA template plasmid (SC111147) was obtained from Origene
Showing 1-1 of 1 papers.
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