PTP4A2 (NM_080391) Human Untagged Clone

SKU SC109921

PTP4A2 (untagged)-Human protein tyrosine phosphatase type IVA, member 2 (PTP4A2), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: PTP4A2
• Synonyms: HH7-2; HH13; HU-PP-1; OV-1; PRL-2; PRL2; ptp-IV1a; ptp-IV1b; PTP4A; PTPCAAX2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC109921 sequence for NM_080391 edited (data generated by NextGen Sequencing); ATGAACCGTCCAGCCCCTGTGGAGATCTCCTATGAGAACATGCGTTTTCTGATAACTCAC; AACCCTACCAATGCTACTCTCAACAAGTTCACAGAGGAACTTAAGAAGTATGGAGTGACG; ACTTTGGTTCGAGTTTGTGATGCTACATATGATAAAGCTCCAGTTGAAAAAGAAGGAATC; CACGTTCTAGATTGGCCATTTGATGATGGAGCTCCACCCCCTAATCAGATAGTAGATGAT; TGGTTAAACCTGTTAAAAACCAAATTTCGTGAAGAGCCAGGTTGCTGTGTTGCAGTGCAT; TGTGTTGCAGGATTGGGAAGGGCACCTGTGCTGGTTGCACTTGCTTTGATTGAATGTGGA; ATGAAGTACGAAGATGCAGTTCAGTTTATAAGACAAAAAAGAAGGGGAGCGTTCAATTCC; AAACAGCTGCTTTATTTGGAGAAATACCGACCTAAGATGCGATTACGCTTCAGAGATACC; AATGGGCATTGCTGTGTTCAGTAG; ; Clone variation with respect to NM_080391.3;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_080391 unedited; GCACATTTGTATACGACTCCTATAGGCGGCCGCGNAATTCGCACGAGGCCGCCGCCGCCG; CCGCCGCCGAGGTGACTGAGGAGAGAGGCGCCTCCTCGCTCCCGCCACCGCCGGACTTCA; ATGCCCAGTCCCCAGCTCGCCAGCGTTTTTCGTTGGAATATACGTTGCACATTTATGGCG; ATTCTGAGTGTGAGGGCAGACTTCTGCCAGGCTCAGCACAGCATTTTCGCTGACAAGTGA; GCTTGGAGGTTCTATGTGCCATAATTAACATTGCCTTGAAGACTCCTGGACACCGAGACT; GGCCTCAGAAATAGTTGGCTTTTTTTTTTTTTTAATTGCAAGCATATTTCTTTTAATGAC; TCCAGTAAAATTAAGCATCAAGTAAACAAGTGGAAAGTGACCTACACTTTTAACTTGTCT; CACTAGTGCCTAAATGTAGTAAAGGCTGCTTAAGTTTTGTATGTAGTTGGATTTTTTGGA; GTCCGAAGGTATCCATCTGCAGAAATTGAGGCCCAAATTGAATTTGGATTCAAGTGGATT; CTAAATACTTTGCTTATCTTGAAGAGAGAAGTTTCATAAGGAATAAACAAGTTGAATAGA; GAAAACACTGATTGATAATAGGCATTTTAGTGGTCTTTTTAATGTTTTCTGCTGTGAAAC; ATTTCAAGATTTATTGATTTTTTTTTTTCACTTTCCCCATNACACTCACACGCACGCTCA; CACTTTTTATTTGCCATAATGAACCGTCCAGCCCCTGTGGAGATCTCCTATGAGAACATG; CGTTTTCTGATAACTCACAACCCTACAATGCTACTCTCAACAAGTCACAGAAGAACTTAG; AAGTTNGAGTGACGATTTTTGTTCGAGTTTGTGATGCTACATATGATAAAGCTCCANTGA; AAAAAAGGNATCCACGTTCTAAATGGCCATTTGATGAGGAGC;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_080391 unedited; ATGGACCGCGGCACGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTACTAAAATGCCCA; GTGGGCTTAAGGCTGCCAGACTGCACGCACATCTACAGCAACAAGGGCTTCTATTCCATC; TACAACTTGGATCGGGGGAAAAGGGAGATGTAGGAGAGGAAGGAAAAAAGAGGGGAAAAA; TATACCACCAACCCTCCCCCACAAAAAAAGGGAAAAAAAAAATCCCACCACAGGGAGATC; TATGTGCCAAGCATAATGGAAGAGTGTGCTCCCCAAACAGATGGTTTTGCACAGGCTAAT; GTTCTGCTGGTTTTCCTTAAAGACCTATTTTGAAAAAGTTTAAAAAGACAGGAGATTTCA; AAATAATTCAATCCTGGCAGAAATTCAAACTCCAAAACTAGGAGCAAAATCATCCTTCAC; TGAATTAATTCCTTTTCTCTTTCTCTTTTCTTAAACATTTTATTCATTTTATAGAGAGAT; TTCTTTTTTGTTTGCTTTTGTTCCAATCATTAGGAGAGTGGTTGAGGAGTACTGAATCCA; TCACTACTTTGATGACACAGGTAATATTCCAGATTCACATTTCCAGGTACCAAGAGTTCC; CTCTAAATGGCACAATCAAGTCAGCCTTCGTTTACATTTCCTTCTACTGAACACAGCAAT; GCCCATTGGTATCTCTGAAGCGTAATCGCATCTTAAGTCGGTATTTCTCCAAATAAAGCA; GCTGTTTGGAATTGAACGCTCCCCTTCTTTTTTGTCTTATAACTGAACTGCATCTTCGTA; CTTCATCCACATTCAATCAAAGCAGTGAACCAGCACAGGTGCCCTTTCCAATCCTGCACA; CAATGCACTGCAACACAGCAACCTGGCTCTCACGAAATTTGGTTTTTACAGGNTAAACCA; TCTCTACATCTGATAGGGGGTGGAGCTCATCATAAAGGCCATCTAAACGCGGATCCTCTC; TTTCACTGGAGCTTATATTGTACCTACCACTCCACN;
• Restriction Sites: NotI-NotI
• ACCN: NM_080391
• Insert Size: 2150 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_080391.1, NP_536316.1
• RefSeq Size: 2084 bp
• RefSeq ORF: 504 bp
• Locus ID: 8073
• UniProt ID: Q12974
• Cytogenetics: 1p35.2
• Domains: PTPc_motif, Y_phosphatase
• Protein Families: Druggable Genome, Phosphatase
• Summary: The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]; Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 6 and 7 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.