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COMT (NM_007310) Human Untagged Clone

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SKU
SC109094
COMT (untagged)-Human catechol-O-methyltransferase (COMT), transcript variant 4
  $300.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol COMT
Synonyms HEL-S-98n
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC109094 sequence for NM_007310 edited (data generated by NextGen Sequencing)
ATGGGTGACACCAAGGAGCAGCGCATCCTGAACCACGTGCTGCAGCATGCGGAGCCCGGG
AACGCACAGAGCGTGCTGGAGGCCATTGACACCTACTGCGAGCAGAAGGAGTGGGCCATG
AACGTGGGCGACAAGAAAGGCAAGATCGTGGACGCCGTGATTCAGGAGCACCAGCCCTCC
GTGCTGCTGGAGCTGGGGGCCTACTGTGGCTACTCAGCTGTGCGCATGGCCCGCCTGCTG
TCACCAGGGGCGAGGCTGATCACCATCGAGATCAACCCCGACTGTGCCGCCATCACCCAG
CGGATGGTGGATTTCGCTGGCGTGAAGGACAAGGTCACCCTTGTGGTTGGAGCGTCCCAG
GACATCATCCCCCAGCTGAAGAAGAAGTATGATGTGGACACACTGGACATGGTCTTCCTC
GACCACTGGAAGGACCGGTACCTGCCGGACACGCTTCTCTTGGAGGAATGTGGCCTGCTG
CGGAAGGGGACAGTGCTACTGGCTGACAACGTGATCTGCCCAGGTGCGCCAGACTTCCTA
GCACACGTGCGCGGGAGCAGCTGCTTTGAGTGCACACACTACCAATCGTTCCTGGAATAC
AGGGAGGTGGTGGACGGCCTGGAGAAGGCCATCTACAAGGGCCCAGGCAGCGAAGCAGGG
CCCTGA

Clone variation with respect to NM_007310.2
258 c=>g
5' Read Nucleotide Sequence
>OriGene 5' read for NM_007310 unedited
TATTTTGTAATACGACTCACTATAGGGCGGCCCGCGAATTCGCACGAGGGCACAAGGCTG
GCATTTCTGAACCTTGCCCCTCTGCGAACACAAGGGGGCGATGGTGGCACTCCAAGCAAA
GGGGCGTGTGGGTGCTGCAGGAGGAGCACAGAGCACTGGCGCCCCTCCCCTCCCGCCCTG
CAGATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTG
GTGGTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAAC
GAGTTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATC
CTGAACCACGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATT
GACACCTACTGCGAGCAGAAGGAGTGGGCCATGAACGTGGGCGACAAGAAAGGCAAGATC
GTGGACGCCGTGATTCAGGAGCACCAGCCCTCCGTGCTGCTGGAGCTGGGGGCCTACTGT
GGCTACTCAGCTGTGCGCATGGCCCGCCTGCTGTCACCAGGGGCGAGGCTGATCACCATC
GAGATCAACCCCGACTGTGCCGCCATCACCCAGCGGATGGTGGATTTCGCTGGCGTGAAG
GACAGGTCACCCTTGTGGTTGGAGCGTCCCAGGACATCATCCCCCAGCTGAAGAAGAAGT
ATGATGTGGACACACTGGACATGGTCTTCCTCGACCCTGGAAGGACCGTACCTGCCGNAC
ACGCTTCTCTTGGNAGAATGTGNCTGCTGCNGAGGNGACAGTGCTACTGGCTGANCACGT
GATCTGCCCCAGTGCGCCAGACTTCCTAGCACACGTGCGCGGGAGCAGT
3' Read Nucleotide Sequence
>OriGene 3' read for NM_007310 unedited
GGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAATTTCTATT
TTATATTTTTAAAACATGATATTAGTATATAAGATAATATAGCTAGCCAGTGTTAGTAAA
GAAGTCATGATTGAGTCTTAAAAAAGAACAATCCAGTGTTGCAGTTCAAAGAGGTTAGCA
TGTCAGGGCGCAGGCCTCGGCCGAGGTGTGCTTTGCATTTAGGACACAGCCCGGAGCCGC
AAAAGGTCAGCAGGAGCACGTCTGGCACCTTCAGTACCAGGCTGGGTGAAAGAGCCCGAG
AGGGGGGCCGGGGGGGGCAGTCAGGGCCCTGCTTCGCTGCCTGGGCCCTTGTAAATGGCC
TTCTCCAGGCCGTCCACCACCTCCCTGTATTCCAGGAACGATTGGTAGTGTGTGCACTCA
AAGCAGCTGCTCCCGCGCACGTGTGCTAGGAAGTCTGGCGCACCTGGGCAGATCACGTTG
TCAGCCAGTAGCACTGTCCCCTTCCGCAGCAGGCCACATTCCTCCAAGAGAAGCGTGTCC
GGCAGGTACCGGTCCTTCCAGTGGTCGAGGAAGACCATGTCCAGTGTGTCCACATCATAC
TTCTTCTTCAGCTGGGGGATGATGTCCTGNGACGCTCCAACCACAAGGTGACCTTGTCCT
TCACGCCAGCGAAATCCACCATCCGCTGGGTGATGGCGGCACAGTCGGGGGTTGATCTCG
ATGGTGATCAACCTCGCCCCCTGGGACAGCAAGCGGGCCATGCGCACAGCTGAGTACCCA
CATAGGCCCCCACTCCAGCACCCGGAAGGCTGTGCCTCTGAATACAGAGTCCACATCTTG
CTTTTTGTCGCCACGTTCATGGCCATTCTTCTGCTCCAGTAGGTGTAAGGCCTTCACACC
CTTGGGCGTCCGGCCTCCCATGCTGAAACGTGTTCAGGACN
Restriction Sites NotI-NotI |
ACCN NM_007310
Insert Size 1280 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_007310.1, NP_009294.1
RefSeq Size 1067 bp
RefSeq ORF 666 bp
Locus ID 1312
UniProt ID P21964
Cytogenetics 22q11.21
Protein Families Druggable Genome, Transmembrane
Protein Pathways Metabolic pathways, Tyrosine metabolism
Summary Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. provided by RefSeq, Sep 2008
Transcript Variant: This variant (4, also known as S-COMT) contains a shorter 5' UTR and a translation start site which lies 50 codons downstream compared to that of variant 1. The resulting isoform (S-COMT) is shorter at the N-terminus compared to isoform MB-COMT. S-COMT is a soluble protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.
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Documents
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"NM_007310" in other vectors (5)
SKU Description Size Price
RC204127 COMT (Myc-DDK-tagged)-Human catechol-O-methyltransferase (COMT), transcript variant 4 10 ug
$289.00 $300.00
RC204127L3 Lenti-ORF clone of COMT (Myc-DDK-tagged)-Human catechol-O-methyltransferase (COMT), transcript variant 4 10 ug
$600.00
RC204127L4 Lenti-ORF clone of COMT (mGFP-tagged)-Human catechol-O-methyltransferase (COMT), transcript variant 4 10 ug
$600.00
RG204127 COMT (tGFP-tagged) - Human catechol-O-methyltransferase (COMT), transcript variant 4 10 ug
$489.00 $500.00
SC320911 COMT (untagged)-Human catechol-O-methyltransferase (COMT), transcript variant 4 10 ug
$300.00

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