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CCR6 (NM_004367) Human Untagged Clone

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SKU
SC109083
CCR6 (untagged)-Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 1
  $457.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol CCR6
Synonyms BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196; CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC109083 sequence for NM_004367 edited (data generated by NextGen Sequencing)
ATGAGCGGGGAATCAATGAATTTCAGCGATGTTTTCGACTCCAGTGAAGATTATTTTGTG
TCAGTCAATACTTCATATTACTCAGTTGATTCTGAGATGTTACTGTGCTCCTTGCAGGAG
GTCAGGCAGTTCTCCAGGCTATTTGTACCGATTGCCTACTCCTTGATCTGTGTCTTTGGC
CTCCTGGGGAATATTCTGGTGGTGATCACCTTTGCTTTTTATAAGAAGGCCAGGTCTATG
ACAGACGTCTATCTCTTGAACATGGCCATTGCAGACATCCTCTTTGTTCTTACTCTCCCA
TTCTGGGCAGTGAGTCATGCCACCGGTGCGTGGGTTTTCAGCAATGCCACGTGCAAGTTG
CTAAAAGGCATCTATGCCATCAACTTTAACTGCGGGATGCTGCTCCTGACTTGCATTAGC
ATGGACCGGTACATCGCCATTGTACAGGCGACTAAGTCATTCCGGCTCCGATCCAGAACA
CTACCGCGCAGCAAAATCATCTGCCTTGTTGTGTGGGGGCTGTCAGTCATCATCTCCAGC
TCAACTTTTGTCTTCAACCAAAAATACAACACCCAAGGCAGCGATGTCTGTGAACCCAAG
TACCAGACTGTCTCGGAGCCCATCAGGTGGAAGCTGCTGATGTTGGGGCTTGAGCTACTC
TTTGGTTTCTTTATCCCTTTGATGTTCATGATATTTTGTTACACGTTCATTGTCAAAACC
TTGGTGCAAGCTCAGAATTCTAAAAGGCACAAAGCCATCCGTGTAATCATAGCTGTGGTG
CTTGTGTTTCTGGCTTGTCAGATTCCTCATAACATGGTCCTGCTTGTGACGGCTGCAAAT
TTGGGTAAAATGAACCGATCCTGCCAGAGCGAAAAGCTAATTGGCTATACGAAAACTGTC
ACAGAAGTCCTGGCTTTCCTGCACTGCTGCCTGAACCCTGTGCTCTACGCTTTTATTGGG
CAGAAGTTCAGAAACTACTTTCTGAAGATCTTGAAGGACCTGTGGTGTGTGAGAAGGAAG
TACAAGTCCTCAGGCTTCTCCTGTGCCGGGAGGTACTCAGAAAACATTTCTCGGCAGACC
AGTGAGACCGCAGATAACGACAATGCGTCGTCCTTCACTATGTGA

Clone variation with respect to NM_004367.5
5' Read Nucleotide Sequence
>OriGene 5' read for NM_004367 unedited
CGAGGTTTGTAAACGACTTCTGATAGGCGGCCGACGATTCGGCACGAGGAGCAGTGTGGC
CGGAGAGGAGAGCTGGGCTGGGAGCACAGGAAGGTCCCCAGGACTCTGTGGTCATCAGTA
AGAGAGGGCCCACGTGTATATGCTGGTGAACAGAAATGTCAACCTTTTCAAAGTCTGACA
TTTAAGAGAAAAAACTGTGGCTGTTGGTTTGTTTAACAGACAGCTCCTTCTTTATTGAGT
CACCTCTACTTTCCTGCTACCGCTGCCTGTGAGCTGAAGGGGCTGAACCATACACTCCTT
TTTCTACAACCAGCTTGCATTTTTTCTGCCCACAATGAGCGGGGAATCAATGAATTTCAG
CGATGTTTTCGACTCCAGTGAAGATTATTTTGTGTCAGTCAATACTTCATATTACTCAGT
TGATTCTGAGATGTTACTGTGCTCCTTGCAAGAGGTCAGGCAGTTCTCCAGGCTATTTGT
ACCGATTGCCTACTCCTTGATCTGTGTCTTTGGCCTCCTGGGGAATATTCTGGTGGTGAT
CACCTTTGCTTTTTATAAGAAGGCCAGGTCTATGACAGACGTCTATCTCTTGAACATGGC
CATTGCAGACATCCTCTTTGTTCTTACTCTCCCATTCTGGGCAGTGAGTCATGCCACCGG
TGCGTGGGTTTTCATGCATGCCACGTGCAAGTTGCTAAAAGGCATCTATGCCATCAACTT
TAACTGGCGGATGCTGCTCCTGACTTGCATTAGCATGGACCGGTACATCGCCATTGTACA
GGCGACTAAGTCATTCCCGGCTCCGATCCAGNACACTACCGCGCAGCAAAATCATCTGCC
TTAGTGTGTGGGGGCTGTCAGTCATCATCTCCAGCTCAACTTTTGTCTTCAACCATAATA
CCACAACCCAGGCAGCGATGTCTGGGAA
3' Read Nucleotide Sequence
>OriGene 3' read for NM_004367 unedited
CCGCGGCCGCATCTANATCGAGTTTTTTTTTTTTTTTTTTACATGTACAAAACACATTTT
TTATTTTGCAAAGCCAAAGCCATGCTTTAAAAATACAGACTTTGAATCTTAAGACATTAT
TTTGCATTTTAAAGAGAGATATAGTTAAAGCTTACAAGAACAATATAAAGTTTCAAATAA
CACCATTGTCAGGTTTAAACATGTCGGTATGTTTACATGACAGTTCTTTCCTTTTTTTTT
TTTTTTTTTTTTTTGAGAGGGAGTCTCGCTTTGTCACCCAGGCTGGAGTGCAATGGCACG
ATCTCGGGTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTTTTTTGCCTCACCCTCC
CAAGTAGCTGGGATTACAGGCCCCCGCCACCACGCCTGGGAAATTTTTGTATTTTTAGTA
AAGAGGGGTTTCCCCCTGTTGGCCAGGCTGGTCTCAAACTCCTGACCCTCAGAGATCCAC
CCCTCCTGACTTCCTAAAAAGCCGGGATACCAGGTGTGCACCTTCCTTGACTACACTTGG
ACAGTCCTGGTTAACGACACGTCGTCGCTTTCTTTCCCGCTTCTCCTTCCTGCGTCCCTT
CCACATCTCTTGCTCCTTCGCTCTGCCCCGCCTCGCCCCGTGCTAACCTGATATAAATAT
ATTTTCTCCCTTCTTCTTCCCTCCCCCCCATTCCGTCCTTTCCCATCCTCCCTCTCTCTC
TCTCTTCCCGTCTTTCCCCCCCCTCCCACCCTTCCCCCCTCCCCCCCGATACGTTATTCT
GCCGCCACTCTCCCCCTCGCTCATGTTTCGTTTCTCCATACCCCCTCATTTCCCCGTTCC
ATTTCCACACCCANCACTCATATCTCATTTTTCGTCGCTTTCCTCCCCGCCCACCCGTAT
TTTTTTTCATAGTATTCCCCCCTCCCGCCCATATCCCATTCTC
Restriction Sites NotI-NotI |
ACCN NM_004367
Insert Size 3410 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_004367.3, NP_004358.2
RefSeq Size 3177 bp
RefSeq ORF 1125 bp
Locus ID 1235
UniProt ID P51684
Cytogenetics 6q27
Domains 7tm_1
Protein Families Druggable Genome, GPCR, Transmembrane
Protein Pathways Chemokine signaling pathway, Cytokine-cytokine receptor interaction
Summary This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. provided by RefSeq, Jul 2008
Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same protein.
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Documents
Resources
"NM_004367" in other vectors (6)
SKU Description Size Price
RC217036 CCR6 (Myc-DDK-tagged)-Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 1 10 ug
$457.00
RC217036L1 Lenti ORF clone of Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 1, Myc-DDK-tagged 10 ug
$757.00
RC217036L2 Lenti ORF clone of Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 1, mGFP tagged 10 ug
$757.00
RC217036L3 Lenti ORF clone of Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 1, Myc-DDK-tagged 10 ug
$757.00
RC217036L4 Lenti ORF clone of Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 1, mGFP tagged 10 ug
$757.00
RG217036 CCR6 (tGFP-tagged) - Human chemokine (C-C motif) receptor 6 (CCR6), transcript variant 1 10 ug
$489.00 $657.00

file-alt Citations

Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8
Jensen, Nygaard, Thiele et al
Mol Pharmacol (2007) 72 (2), 327-40 DOI: 10.1124/mol.106.035543
Cited by 59
AI Summary: OriGene products contributed to this study by providing the human CCR8 cDNA (Cat# SC116187) and CCR8 expression plasmids, which were used for receptor expression and mutagenesis experiments to investigate the molecular interactions of nonpeptide agonists with CCR8.
Showing 1-1 of 1 papers.
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