Beta Arrestin 2 (ARRB2) (NM_004313) Human Untagged Clone
$686.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | Beta Arrestin 2 |
| Synonyms | ARB2; ARR2; BARR2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_004313 |
| Insert Size | 1880 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_004313.3, NP_004304.1 |
| RefSeq Size | 1936 bp |
| RefSeq ORF | 1230 bp |
| Locus ID | 409 |
| UniProt ID | P32121 |
| Cytogenetics | 17p13.2 |
| Domains | arrestin |
| Protein Families | Druggable Genome |
| Protein Pathways | Chemokine signaling pathway, Endocytosis, MAPK signaling pathway, Olfactory transduction |
| Summary | Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Mar 2012 Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 3. The resulting isoform (1) lacks an alternate internal segment compared to isoform 3. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_004313" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC201168 | ARRB2 (Myc-DDK-tagged)-Human arrestin, beta 2 (ARRB2), transcript variant 1 | 10 ug |
$289.00
$686.00
|
|
| RC201168L1 | Lenti ORF clone of Human arrestin, beta 2 (ARRB2), transcript variant 1, Myc-DDK-tagged | 10 ug |
$986.00
|
|
| RC201168L2 | Lenti ORF clone of Human arrestin, beta 2 (ARRB2), transcript variant 1, mGFP tagged | 10 ug |
$986.00
|
|
| RC201168L3 | Lenti ORF clone of Human arrestin, beta 2 (ARRB2), transcript variant 1, Myc-DDK-tagged | 10 ug |
$986.00
|
|
| RC201168L4 | Lenti ORF clone of Human arrestin, beta 2 (ARRB2), transcript variant 1, mGFP tagged | 10 ug |
$986.00
|
|
| RG201168 | ARRB2 (tGFP-tagged) - Human arrestin, beta 2 (ARRB2), transcript variant 1 | 10 ug |
$489.00
$886.00
|
|
Citations
Overexpression of β-Arrestins inhibits proliferation and motility in triple negative breast cancer cells
Bostanabad, Noyan, Dedeoglu et al
Sci Rep (2021) 11 (1), 1539 DOI: 10.1038/s41598-021-80974-6
Bostanabad, Noyan, Dedeoglu et al
Sci Rep (2021) 11 (1), 1539 DOI: 10.1038/s41598-021-80974-6
Cited by 19
AI Summary: OriGene products, including human β-arrestin-1 cDNA (SC303424), β-arrestin-2 cDNA (SC108950), TurboFectin 8.0 transfection reagent (TF81001), and cloning vectors PCMV6-XL6 and PCMV6-XL5, were used to modulate β-arrestin expression and facilitate transfection in triple negative breast cancer cells for functional studies in this paper.
Snippet: 424), human β-arrestin-2 (ARRB2) cDNA (SC108950), TurboFectin 8.0 transfection reagent (TF81001), cloning vector PCMV6-XL6 (PCMV6XL6), and cloning vector PCMV6-XL5 (PCMV6XL5) were all purchased from OriGene Technologies, MD, USA. The antibodies, β-Arrestin-1 (sc-9182), β-Arrestin-2 (sc-13140), CDC45 (sc-55569, CCNB1 (sc-245), CCNB2 (sc-28303), BUB1 (sc-365685), GAPDH (1:5,000;Sc-166545), goat;- 1 (ARRB1) cDNA (SC303424), human β-arrestin-2 (ARRB2) cDNA (SC108950), TurboFec- tin 8.0 transfection reagent (TF81001), cloning vector PCMV6-XL6 (PCMV6XL6), and cloning vector PCMV6- XL5 (PCMV6XL5) were all purchased from OriGene Technologies
Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex
Bjørgo, Solheim, Abrahamsen et al
Mol Cell Biol (2010) 30 (7), 1660-72 DOI: 10.1128/MCB.00696-09
Bjørgo, Solheim, Abrahamsen et al
Mol Cell Biol (2010) 30 (7), 1660-72 DOI: 10.1128/MCB.00696-09
AI Summary: In this study, OriGene’s anti-beta-arrestin antibody (ABR-001) and anti-PDE4 antibody (ABR-002) were used to detect and analyze the beta-arrestin/PDE4 complex, helping to elucidate its role in linking PI3K and cAMP-PKA signaling pathways during T-cell activation.
Crosstalk between PI3-Kinase and cAMP-Protein Kinase A signaling pathways at the level of a Protein Kinase B/{beta}-arrestin/cAMP phosphodiesterase-4 complex
Bjørgo, Solheim, Abrahamsen et al
Mol. Cell. Biol (2010)
Bjørgo, Solheim, Abrahamsen et al
Mol. Cell. Biol (2010)
Site-specific cleavage of GPCR-engaged Beta-arrestin: Influence of the AT1 receptor conformation on scissile site selection
Lee, Bhatt, Shukla et al
J. Biol. Chem (2008)
Lee, Bhatt, Shukla et al
J. Biol. Chem (2008)
Showing 1-4 of 4 papers.
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