ABCD2 (NM_005164) Human Tagged ORF Clone
- TrueORF®
SKU
RG211199
ABCD2 (tGFP-tagged) - Human ATP-binding cassette, sub-family D (ALD), member 2 (ABCD2)
$789.00
$878.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | ABCD2 |
| Synonyms | ABC39; ALDL1; ALDR; ALDRP; hALDR |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_005164 |
| ORF Size | 2220 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_005164.4 |
| RefSeq Size | 3969 bp |
| RefSeq ORF | 2223 bp |
| Locus ID | 225 |
| UniProt ID | Q9UBJ2 |
| Cytogenetics | 12q12 |
| Domains | AAA, ABC_tran |
| Protein Families | Druggable Genome |
| Protein Pathways | ABC transporters |
| Summary | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_005164" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC211199 | ABCD2 (Myc-DDK-tagged)-Human ATP-binding cassette, sub-family D (ALD), member 2 (ABCD2) | 10 ug |
$678.00
|
|
| RC211199L1 | Lenti ORF clone of Human ATP-binding cassette, sub-family D (ALD), member 2 (ABCD2), Myc-DDK-tagged | 10 ug |
$978.00
|
|
| RC211199L2 | Lenti ORF clone of Human ATP-binding cassette, sub-family D (ALD), member 2 (ABCD2), mGFP tagged | 10 ug |
$978.00
|
|
| RC211199L3 | Lenti ORF clone of Human ATP-binding cassette, sub-family D (ALD), member 2 (ABCD2), Myc-DDK-tagged | 10 ug |
$978.00
|
|
| RC211199L4 | Lenti ORF clone of Human ATP-binding cassette, sub-family D (ALD), member 2 (ABCD2), mGFP tagged | 10 ug |
$978.00
|
|
| SC310135 | ABCD2 (untagged)-Human ATP-binding cassette, sub-family D (ALD), member 2 (ABCD2) | 10 ug |
$746.00
|
|
Citations
ABCD2 is a direct target of β-catenin and TCF-4: implications for X-linked adrenoleukodystrophy therapy
Park, Kim, Jang et al
PLoS ONE (2013) 8 (2), e56242 DOI: 10.1371/journal.pone.0056242
Park, Kim, Jang et al
PLoS ONE (2013) 8 (2), e56242 DOI: 10.1371/journal.pone.0056242
Cited by 17
AI Summary: OriGene’s human ABCD2-GFP expression vector (#RG211199) was used in this study to investigate the functional effects of ABCD2 overexpression on very long chain fatty acid levels, contributing to the elucidation of ABCD2 regulation and its therapeutic potential in X-linked adrenoleukodystrophy.
Snippet: plasmid #24204, #16514, #24310, respectively;Cambridge CA) [27], [28]. The human ABCD2-GFP expression vector was purchased from OriGene (#RG211199). Human ABCD2 promoter fragments (−1300, −800, −500, −1300
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
