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EXTL2 (NM_001439) Human Tagged ORF Clone

  • TrueORF®
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SKU
RG207406
EXTL2 (tGFP-tagged) - Human exostoses (multiple)-like 2 (EXTL2), transcript variant 1
ORF Plasmid:
tGFP DDK
Lentiviral Particles:
DDK mGFP DDK w/ Puro mGFP w/ Puro
AAV Particle:
DDK
$489.00 $500.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone
Target Symbol EXTL2
Synonyms EXTR2
Vector pCMV6-AC-GFP
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
ORF Nucleotide Sequence
>RG207406 representing NM_001439
Red=Cloning site Blue=ORF Green=Tags(s)

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGAGGTGTTGCCACATCTGCAAACTTCCTGGGAGAGTAATGGGGATTCGAGTGCTTCGATTATCTTTGG
TGGTCATCCTCGTATTATTACTGGTAGCTGGTGCTTTGACTGCCTTACTTCCCAGTGTTAAAGAAGACAA
GATGCTCATGTTGCGTAGGGAAATAAAATCCCAGGGCAAGTCCACCATGGACTCCTTTACTCTCATAATG
CAGACGTACAACAGAACAGATCTCTTATTGAAACTTTTAAATCATTATCAGGCTGTACCAAATCTGCACA
AAGTGATTGTGGTATGGAACAATATTGGAGAGAAGGCACCAGATGAATTATGGAATTCTCTAGGGCCCCA
CCCTATCCCTGTGATCTTCAAACAACAGACAGCAAACAGGATGAGAAATCGACTCCAGGTCTTTCCTGAA
CTGGAAACCAATGCAGTGTTGATGGTAGATGATGACACACTCATCAGCACCCCAGACCTTGTTTTTGCTT
TCTCAGTTTGGCAGCAATTTCCTGATCAAATTGTAGGATTTGTTCCTAGAAAGCACGTCTCTACTTCATC
AGGTATCTACAGTTATGGAAGTTTTGAAATGCAAGCACCAGGGTCTGGAAATGGTGACCAGTACTCTATG
GTGCTGATTGGAGCCTCATTCTTCAATAGCAAATATCTTGAATTATTTCAGAGGCAACCTGCAGCTGTCC
ATGCTTTGATAGATGATACTCAAAACTGTGATGATATTGCCATGAATTTTATCATTGCCAAGCATATTGG
CAAGACTTCAGGGATATTTGTGAAGCCTGTAAACATGGACAATTTGGAAAAAGAAACCAACAGTGGCTAT
TCTGGAATGTGGCATCGAGCTGAGCACGCTCTGCAGAGGTCTTATTGTATAAATAAGCTTGTTAATATCT
ATGATAGCATGCCCTTAAGATACTCCAACATTATGATTTCCCAGTTTGGTTTTCCATATGCCAACTACAA
AAGAAAAATA

ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
Protein Sequence
>RG207406 representing NM_001439
Red=Cloning site Green=Tags(s)

MRCCHICKLPGRVMGIRVLRLSLVVILVLLLVAGALTALLPSVKEDKMLMLRREIKSQGKSTMDSFTLIM
QTYNRTDLLLKLLNHYQAVPNLHKVIVVWNNIGEKAPDELWNSLGPHPIPVIFKQQTANRMRNRLQVFPE
LETNAVLMVDDDTLISTPDLVFAFSVWQQFPDQIVGFVPRKHVSTSSGIYSYGSFEMQAPGSGNGDQYSM
VLIGASFFNSKYLELFQRQPAAVHALIDDTQNCDDIAMNFIIAKHIGKTSGIFVKPVNMDNLEKETNSGY
SGMWHRAEHALQRSYCINKLVNIYDSMPLRYSNIMISQFGFPYANYKRKI

TRTRPLE - GFP Tag - V
Restriction Sites SgfI-MluI Cloning Scheme for this gene |
ACCN NM_001439
ORF Size 990 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001439.4
RefSeq Size 2905 bp
RefSeq ORF 993 bp
Locus ID 2135
UniProt ID Q9UBQ6
Cytogenetics 1p21.2
Protein Families Transmembrane
Protein Pathways Heparan sulfate biosynthesis
Summary Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.UniProtKB/Swiss-Prot Function
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Documents
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"NM_001439" in other vectors (6)
SKU Description Size Price
RC207406 EXTL2 (Myc-DDK-tagged)-Human exostoses (multiple)-like 2 (EXTL2), transcript variant 1 10 ug
$300.00
RC207406L1 Lenti ORF clone of Human exostoses (multiple)-like 2 (EXTL2), transcript variant 1, Myc-DDK-tagged 10 ug
$600.00
RC207406L2 Lenti ORF clone of Human exostoses (multiple)-like 2 (EXTL2), transcript variant 1, mGFP tagged 10 ug
$600.00
RC207406L3 Lenti ORF clone of Human exostoses (multiple)-like 2 (EXTL2), transcript variant 1, Myc-DDK-tagged 10 ug
$600.00
RC207406L4 Lenti ORF clone of Human exostoses (multiple)-like 2 (EXTL2), transcript variant 1, mGFP tagged 10 ug
$600.00
SC108768 EXTL2 (untagged)-Human exostoses (multiple)-like 2 (EXTL2), transcript variant 1 10 ug
$300.00

file-alt Citations

Reduced expression of EXTL2, a member of the EXT family of glycosyltransferases, in human embryonic kidney 293 cells results in longer heparan sulfate chains
Katta, Imran, Busse-Wicher et al
J. Biol. Chem. (2015)
AI Summary: In this study, OriGene's C-terminal TurboGFP (tGFP)-tagged full-length human EXTL2 cDNA clone in the pCMV6-AC-GFP vector was used to overexpress EXTL2 in HEK293 cells, enabling investigation of its role in heparan sulfate chain elongation.
Snippet: Alternatively, HEK293 cells were transfected using the Nucleofector electroporation kit for adherent cells (Amaxa) with a C-terminal TurboGFP (tGFP)-tagged full- length human EXTL2 cDNA clone in the pCMV6-AC-GFP vector (Origene). ... Cite SaveSaving
Showing 1-1 of 1 papers.
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