EXD2 (NM_001193360) Human Tagged ORF Clone
SKU
RC231340
EXD2 (Myc-DDK-tagged)-Human exonuclease 3'-5' domain containing 2 (EXD2), transcript variant 1
$578.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | EXD2 |
| Synonyms | C14orf114; EXDL2 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_001193360 |
| ORF Size | 1863 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_001193360.1, NP_001180289.1 |
| RefSeq ORF | 1866 bp |
| Locus ID | 55218 |
| UniProt ID | Q9NVH0 |
| Cytogenetics | 14q24.1 |
| MW | 70.8 kDa |
| Summary | Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_001193360" in other vectors (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC231340L3 | Lenti-ORF clone of EXD2 (Myc-DDK-tagged)-Human exonuclease 3'-5' domain containing 2 (EXD2), transcript variant 1 | 10 ug |
$878.00
|
|
| RC231340L4 | Lenti-ORF clone of EXD2 (mGFP-tagged)-Human exonuclease 3'-5' domain containing 2 (EXD2), transcript variant 1 | 10 ug |
$878.00
|
|
| RG231340 | EXD2 (tGFP-tagged) - Human exonuclease 3'-5' domain containing 2 (EXD2), transcript variant 1 | 10 ug |
$778.00
|
|
Citations
The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair
Hensen, Moretton, van Esveld et al
Sci Rep (2018) 8 (1), 5368 DOI: 10.1038/s41598-018-23690-y
Hensen, Moretton, van Esveld et al
Sci Rep (2018) 8 (1), 5368 DOI: 10.1038/s41598-018-23690-y
AI Summary: OriGene contributed to this study by providing the commercial cDNA clone for the predicted full-length EXD2 containing a Myc-DDK (FLAG) tag (OriGene Catalogue number not specified), which was used for EXD2 overexpression experiments to assess its cellular localization.
Snippet: As controls we used Stealth TM Universal negative controls at the same concentrations. A commercial cDNA clone for the predicted full-length cDNA for EXD2 and containing a Myc-DDK (FLAG) tag was acquired from Origene (Catalogue nr
Showing 1-1 of 1 papers.
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in shipping.
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