IL6R (NM_000565) Human Tagged ORF Clone
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | IL6R |
| Synonyms | CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1; IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_000565 |
| ORF Size | 1404 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_000565.4 |
| RefSeq Size | 4176 bp |
| RefSeq ORF | 1407 bp |
| Locus ID | 3570 |
| UniProt ID | P08887 |
| Cytogenetics | 1q21.3 |
| Domains | FN3, ig, IG, IGc2 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway |
| MW | 51.5 kDa |
| Summary | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. provided by RefSeq, Aug 2020 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_000565" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC221874L1 | Lenti ORF clone of Human interleukin 6 receptor (IL6R), transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC221874L2 | Lenti ORF clone of Human interleukin 6 receptor (IL6R), transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RC221874L3 | Lenti ORF clone of Human interleukin 6 receptor (IL6R), transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC221874L4 | Lenti ORF clone of Human interleukin 6 receptor (IL6R), transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RG221874 | IL6R (tGFP-tagged) - Human interleukin 6 receptor (IL6R), transcript variant 1 | 10 ug |
$489.00
$657.00
|
|
| SC119840 | IL6R (untagged)-Human interleukin 6 receptor (IL6R), transcript variant 1 | 10 ug |
$457.00
|
|
Citations
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome
Béziat, Tavernier, Chen et al
J. Exp. Med. (2020) 217 (6) DOI: 10.1084/jem.20191804
Béziat, Tavernier, Chen et al
J. Exp. Med. (2020) 217 (6) DOI: 10.1084/jem.20191804
Cited by 132
Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy
Lee, Wang, Kalaitzidis et al
J. Clin. Invest. (2016) 126 (4), 1300-1310 DOI: 10.1172/JCI84620
Lee, Wang, Kalaitzidis et al
J. Clin. Invest. (2016) 126 (4), 1300-1310 DOI: 10.1172/JCI84620
AI Summary: OriGene contributed STAT3, GP130, and IL6R plasmids to this study, which were used to investigate the molecular interactions and signaling pathways involving UT2 in the regulation of STAT3 activation and hematological malignancy.
Snippet: … STAT3, GP130, and IL6R plasmids were purchased from OriGene. Antibodies to AKT (catalog 4691), pAKTS473 (catalog 4060), STAT3 (catalog 4904), pSTAT3Y705 (catalog 9145), pSTAT1Y701 (catalog 9167), pSTAT5Y694 (catalog 4322), MYC (catalog 2278), and ACTIN (catalog 4970) were from Cell Signaling Technology. GP130 (catalogs sc655 and sc656) and IL6R (catalogs sc661 and sc13947) were from Santa Cruz Biotechnology Inc. …
Showing 1-2 of 2 papers.
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