Neurexin II alpha (NRXN2) (NM_015080) Human Tagged ORF Clone
$1,439.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | Neurexin II alpha |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_015080 |
| ORF Size | 5136 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_015080.4 |
| RefSeq Size | 6616 bp |
| RefSeq ORF | 5139 bp |
| Locus ID | 9379 |
| UniProt ID | Q9P2S2 |
| Cytogenetics | 11q13.1 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs) |
| MW | 184.98 kDa |
| Summary | This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).provided by RefSeq, Jun 2010 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_015080" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC219788L1 | Lenti ORF clone of Human neurexin 2 (NRXN2), transcript variant alpha-1, Myc-DDK-tagged | 10 ug |
$1,739.00
|
|
| RC219788L3 | Lenti ORF clone of Human neurexin 2 (NRXN2), transcript variant alpha-1, Myc-DDK-tagged | 10 ug |
$1,739.00
|
|
| RG219788 | NRXN2 (tGFP-tagged) - Human neurexin 2 (NRXN2), transcript variant alpha-1 | 10 ug |
$1,639.00
|
|
| SC319037 | NRXN2 (untagged)-Human neurexin 2 (NRXN2), transcript variant alpha-1 | 10 ug |
$1,583.00
|
|
Citations
Key role of SMN/SYNCRIP and RNA-Motif 7 in spinal muscular atrophy: RNA-Seq and motif analysis of human motor neurons
Rizzo, Nizzardo, Vashisht et al
Brain (2019) 142 (2), 276-294 DOI: 10.1093/brain/awy330
Rizzo, Nizzardo, Vashisht et al
Brain (2019) 142 (2), 276-294 DOI: 10.1093/brain/awy330
Showing 1-1 of 1 papers.
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