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Estrogen Receptor beta (ESR2) (NM_001437) Human Tagged Lenti ORF Clone

  • LentiORF®
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SKU
RC218519L2
Lenti ORF clone of Human estrogen receptor 2 (ER beta) (ESR2), transcript variant a, mGFP tagged
ORF Plasmid:
mGFP DDK tGFP
Lentiviral Particles:
DDK mGFP DDK w/ Puro mGFP w/ Puro
  $1,040.00
In Stock*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone
Target Symbol Estrogen Receptor beta
Synonyms ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2; ODG8
Vector pLenti-C-mGFP
E. coli Selection Chloramphenicol (34 ug/mL)
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC218519).
Restriction Sites SgfI-MluI Cloning Scheme for this gene | Plasmid Map
ACCN NM_001437
ORF Size 1590 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001437.1
RefSeq Size 2011 bp
RefSeq ORF 1593 bp
Locus ID 2100
UniProt ID Q92731
Cytogenetics 14q23.2-q23.3
Domains HOLI, zf-C4
Protein Families Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
MW 59 kDa
Summary This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. provided by RefSeq, Jul 2008
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Documents
Resources
"NM_001437" in other vectors (6)
SKU Description Size Price
RC218519 ESR2 (Myc-DDK-tagged)-Human estrogen receptor 2 (ER beta) (ESR2), transcript variant a 10 ug
$740.00
RC218519L1 Lenti ORF clone of Human estrogen receptor 2 (ER beta) (ESR2), transcript variant a, Myc-DDK-tagged 10 ug
$1,040.00
RC218519L3 Lenti ORF clone of Human estrogen receptor 2 (ER beta) (ESR2), transcript variant a, Myc-DDK-tagged 10 ug
$1,040.00
RC218519L4 Lenti ORF clone of Human estrogen receptor 2 (ER beta) (ESR2), transcript variant a, mGFP tagged 10 ug
$1,040.00
RG218519 ESR2 (tGFP-tagged) - Human estrogen receptor 2 (ER beta) (ESR2), transcript variant a 10 ug
$940.00
SC119216 ESR2 (untagged)-Human estrogen receptor 2 (ER beta) (ESR2), transcript variant a 10 ug
$741.00

Plasmid Map for RC218519L2

Download sequence for

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Cloning scheme for RC218519L2
Circular map for RC218519L2

file-alt Citations

Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regeneration
Kao, Kuan, Cheng et al
Theranostics (2018) 8 (10), 2672-2682 DOI: 10.7150/thno.23624
AI Summary: OriGene products, specifically cDNA constructs for HNF4α (#RC217863L2), HNF1α (#RC211201L2), and FOXOA3 (#RC202363L2), were used in this study to manipulate gene expression in hepatic cells and investigate the molecular pathways by which estrogen receptors regulate liver regeneration.
Snippet: Lentiviral-based gene expression The cDNAs or shRNA (HNF4α, OriGene #RC217863L2;HNF1α, OriGene #RC211201L2;FOXOA3, OriGene #RC202363L2;ERα, addgene #RC213277L2;ERβ, addgene #RC218519L2;Chd1 and Ube3a [MOST-RNAi core View as HTML
Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regeneration
Kao, Kuan, Cheng et al
Theranostics (2018) 8 (10), 2672-2682 DOI: 10.7150/thno.23624
Cited by 38
AI Summary: In this study, OriGene products, specifically the ERα and ERβ expression plasmids, were used to manipulate estrogen receptor levels in cell models, enabling the authors to investigate the distinct roles of ERα and ERβ in regulating liver cell growth and differentiation during liver regeneration.
FigureFigureFigure
Showing 1-2 of 2 papers.
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