HIPK3 (NM_005734) Human Tagged ORF Clone
SKU
RC214196
HIPK3 (Myc-DDK-tagged)-Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 1
$1,058.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | HIPK3 |
| Synonyms | DYRK6; FIST3; PKY; YAK1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_005734 |
| ORF Size | 3645 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_005734.5 |
| RefSeq Size | 3657 bp |
| RefSeq ORF | 3648 bp |
| Locus ID | 10114 |
| UniProt ID | Q9H422 |
| Cytogenetics | 11p13 |
| Domains | pkinase, S_TKc, TyrKc |
| Protein Families | Druggable Genome, Protein Kinase, Transcription Factors |
| MW | 133.6 kDa |
| Summary | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_005734" in other vectors (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC214196L1 | Lenti ORF clone of Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,358.00
|
|
| RC214196L2 | Lenti ORF clone of Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 1, mGFP tagged | 10 ug |
$1,358.00
|
|
| RC214196L3 | Lenti ORF clone of Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,358.00
|
|
| RC214196L4 | Lenti ORF clone of Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 1, mGFP tagged | 10 ug |
$1,358.00
|
|
| RG214196 | HIPK3 (tGFP-tagged) - Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 1 | 10 ug |
$1,258.00
|
|
| SC315273 | HIPK3 (untagged)-Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 1 | 10 ug |
$1,164.00
|
|
| SC323551 | HIPK3 (untagged)-Kinase deficient mutant (K226M) of Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 1 | 10 ug |
$1,058.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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