ZSCAN4 (NM_152677) Human Tagged ORF Clone
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | ZSCAN4 |
| Synonyms | ZNF494 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_152677 |
| ORF Size | 1299 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_152677.2, NP_689890.1 |
| RefSeq Size | 2260 bp |
| RefSeq ORF | 1302 bp |
| Locus ID | 201516 |
| UniProt ID | Q8NAM6 |
| Cytogenetics | 19q13.43 |
| Protein Families | Transcription Factors |
| MW | 49 kDa |
| Summary | The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 PubMed 20336070).supplied by OMIM, May 2010 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_152677" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC211003L1 | Lenti ORF clone of Human zinc finger and SCAN domain containing 4 (ZSCAN4), Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC211003L2 | Lenti ORF clone of Human zinc finger and SCAN domain containing 4 (ZSCAN4), mGFP tagged | 10 ug |
$757.00
|
|
| RC211003L3 | Lenti ORF clone of Human zinc finger and SCAN domain containing 4 (ZSCAN4), Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC211003L4 | Lenti ORF clone of Human zinc finger and SCAN domain containing 4 (ZSCAN4), mGFP tagged | 10 ug |
$757.00
|
|
| RG211003 | ZSCAN4 (tGFP-tagged) - Human zinc finger and SCAN domain containing 4 (ZSCAN4) | 10 ug |
$489.00
$657.00
|
|
| SC306481 | ZSCAN4 (untagged)-Human zinc finger and SCAN domain containing 4 (ZSCAN4) | 10 ug |
$503.00
|
|
Citations
ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity
Lee, Gollahon
Biochem. Biophys. Res. Commun. (2015)
Lee, Gollahon
Biochem. Biophys. Res. Commun. (2015)
Cited by 13
Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status
Lee, Gollahon
Cancer Biol Ther (2014) 15 (8), 1094-105 DOI: 10.4161/cbt.29220
Lee, Gollahon
Cancer Biol Ther (2014) 15 (8), 1094-105 DOI: 10.4161/cbt.29220
Cited by 29
AI Summary: In this study, OriGene products—specifically the ZSCAN4 Myc-DDK-tagged cDNA (RC222830) and human ZSCAN4 siRNA (SR321804)—were used for Zscan4 overexpression and gene silencing experiments, enabling the authors to investigate Zscan4’s interaction with Rap1 and its role in telomere regulation in cancer cells.
The Interaction of ZSCAN4 with Shelterin Complex Members: A Possible Role for Telomere Regulation in Cancer Cells
Lee
Thesis (2014)
Lee
Thesis (2014)
AI Summary: OriGene’s purified human ZSCAN4 protein (NM_152677) was used as a template to amplify the ZSCAN4 gene for generating fusion proteins, enabling the study of ZSCAN4’s interactions with shelterin complex members in this research.
Snippet: In order to determine whether interaction between ZSCAN4 and other shelterin proteins were direct, a series of protein-‐protein assays was performed. To generate N-‐terminal GST-‐ZSCAN4 fusion proteins, the ZSCAN4 gene was amplified from ZSCAN4 (NM_152677) purified human protein (OriGene) by standard polymerase chain reaction (PCR). …
Showing 1-3 of 3 papers.
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