SELK (SELENOK) (NM_021237) Human Tagged ORF Clone
- TrueORF®
SKU
RC203754
SELK (Myc-DDK-tagged)-Human selenoprotein K (SELK), (Note, selenocysteine protein, internal stop codon, see reference data summary)
$289.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged ORF Clone |
|---|---|
| Target Symbol | SELK |
| Synonyms | HSPC030; HSPC297; SELK |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_021237 |
| ORF Size | 282 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone encodes a selenoprotein containing the rare amino acid selenocysteine (Sec). Sec is encoded by UGA codon, which normally signals translational termination. Expression of this clone is not guaranteed due to the nature of selenoproteins. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_021237.5 |
| RefSeq Size | 832 bp |
| RefSeq ORF | 285 bp |
| Locus ID | 58515 |
| UniProt ID | Q9Y6D0 |
| Cytogenetics | 3p21.1 |
| Protein Families | Transmembrane |
| Summary | The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.provided by RefSeq, Aug 2017 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_021237" in other vectors (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC203754L1 | Lenti-ORF, SELK (Myc-DDK-tagged)-Human selenoprotein K (SELK), (Note, selenocysteine protein, internal stop codon, see summary) | 10 ug |
$450.00
|
|
| RG203754 | SELK (GFP-tagged) - Human selenoprotein K (SELK), (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below) | 10 ug |
$489.00
|
|
| SC100671 | SELK (untagged)-Human selenoprotein K (SELK) (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below) | 10 ug |
$429.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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