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Ptprs (NM_011218) Mouse Tagged ORF Clone

  • TrueORF®
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SKU
MR222172
Ptprs (Myc-DDK-tagged) - Mouse protein tyrosine phosphatase, receptor type, S (Ptprs)
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ORF Plasmid:
DDK tGFP
  $1,603.00
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Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone
Target Symbol Ptprs
Synonyms AL022616; PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9; R-PTP-S; RPTPsigma
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
ORF Nucleotide Sequence
>MR222172 representing NM_011218
Red=Cloning site Blue=ORF Green=Tags(s)

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCGCCCACCTGGAGTCCCAGCGTGGTGTCTGTGGTGGGTCCTGTGGGGCTCTTCCTCGTACTGCTGG
CCAGAGGATGCTTGGCTGAAGAACCACCCAGGTTTATCAGAGAGCCCAAGGATCAGATTGGAGTGTCGGG
AGGCGTGGCCTCCTTCGTGTGCCAGGCCACGGGTGATCCTAAGCCACGGGTGACCTGGAACAAGAAGGGC
AAGAAAGTGAACTCACAGCGCTTCGAGACCATTGACTTTGACGAGAGCTCTGGGGCGGTCCTGAGGATCC
AGCCACTTCGGACGCCTCGGGATGAGAACGTGTACGAGTGTGTGGCCCAGAACTCGGTGGGCGAAATCAC
AATTCATGCAAAGCTCACCGTCCTTCGAGAGGACCAGCTGCCTCCTGGCTTCCCCAACATTGACATGGGC
CCCCAGTTGAAGGTTGTAGAGCGCACACGCACAGCCACCATGCTCTGTGCTGCCAGCGGGAACCCGGACC
CTGAGATCACCTGGTTTAAGGACTTCCTGCCTGTGGACCCCAGTGCCAGCAACGGGCGGATCAAGCAGCT
TCGATCAGGTGCCCTGCAGATTGAGAGCAGCGAGGAGACAGACCAGGGCAAGTACGAGTGTGTGGCCACC
AACAGCGCTGGGGTGCGCTACTCATCACCTGCCAACCTCTACGTGCGAGTCCGCCGTGTGGCCCCACGCT
TCTCCATCCTGCCCATGAGCCACGAGATCATGCCCGGTGGGAATGTGAATATCACTTGTGTGGCCGTGGG
CTCACCCATGCCCTACGTGAAATGGATGCAGGGGGCCGAGGACCTGACGCCTGAGGATGACATGCCCGTG
GGTCGGAATGTTCTAGAACTCACGGATGTCAAGGACTCAGCTAACTACACTTGTGTGGCCATGTCCAGCC
TGGGTGTGATCGAGGCCGTGGCCCAGATCACTGTAAAATCTCTCCCCAAAGCCCCTGGGACTCCTGTGGT
GACGGAGAACACTGCCACCAGTATCACTGTCACATGGGACTCGGGCAACCCTGACCCCGTGTCCTACTAC
GTAATTGAGTATAAGTCCAAAAGCCAGGATGGGCCGTATCAGATCAAAGAAGACATCACCACCACGCGCT
ACAGCATCGGAGGCCTGAGCCCCAATTCTGAGTATGAGATCTGGGTGTCAGCTGTCAACTCCATTGGCCA
GGGCCCTCCCAGTGAATCGGTGGTGACCCGCACAGGTGAGCAGGCACCAGCCAGCGCTCCCAGGAATGTT
CAGGCCCGCATGCTCAGCGCCACCACCATGATCGTGCAGTGGGAGGAGCCTGTGGAGCCCAATGGCCTGA
TCCGTGGCTACCGTGTCTACTATACCATGGAGCCGGAACACCCAGTGGGCAACTGGCAGAAACACAATGT
GGACGACAGTCTCCTGACCACTGTGGGCAGCCTGCTGGAAGACGAGACCTACACCGTGCGCGTGCTCGCC
TTCACGTCGGTGGGCGACGGACCACTGTCAGACCCCATCCAGGTCAAGACCCAGCAGGGAGTTCCTGGCC
AGCCCATGAACTTGCGGGCTGAGGCCAAGTCAGAGACCAGCATTGGGCTCTCGTGGAGTGCACCACGACA
GGAGAGTGTCATTAAGTATGAACTGCTCTTCCGGGAGGGCGACCGAGGCCGAGAGGTGGGGCGAACCTTC
GACCCAACCACAGCCTTTGTGGTGGAGGACCTCAAGCCCAATACGGAGTATGCGTTCCGGCTGGCGGCGC
GCTCGCCGCAGGGCCTGGGCGCCTTCACCGCGGTCGTGCGCCAGCGCACGCTGCAGGCCAAACCGTCAGC
CCCCCCTCAAGACGTTAAGTGCACCAGCTTGCGCTCCACGGCCATATTGGTAAGTTGGCGCCCGCCACCG
CCAGAAACTCACAACGGGGCCCTCGTGGGCTACAGCGTCCGCTACCGACCGCTGGGCTCAGAGGACCCGG
ACCCCAAGGAGGTGAACAACATACCCCCGACCACCACTCAGATCCTTCTGGAAGCTTTGGAGAAATGGAC
GGAGTACCGTGTCACCGCCGTGGCTTACACAGAGGTGGGACCAGGGCCCGAGAGCTCGCCCGTGGTCGTC
CGCACCGATGAGGACGTGCCCAGCGCGCCCCCGCGGAAGGTGGAGGCGGAGGCGCTCAACGCCACAGCCA
TCCGAGTGCTGTGGCGCTCGCCCACGCCCGGCCGGCAGCACGGGCAGATCCGCGGCTACCAGGTCCACTA
TGTGCGCATGGAGGGTGCCGAGGCCCGCGGGCCACCGCGCATCAAGGACATCATGCTGGCGGATGCCCAG
GAAATGGTGATAACGAACCTCCAGCCTGAGACTGCTTACTCTATCACAGTAGCCGCGTATACCATGAAAG
GCGATGGCGCTCGCAGCAAACCGAAGGTGGTGGTGACCAAGGGAGCAGTGCTGGGCCGCCCCACCCTGTC
GGTGCAGCAGACCCCCGAGGGCAGCCTGCTGGCGCGCTGGGAGCCCCCCGCGGACGCGGCCGAGGACCCG
GTGCTTGGCTACCGCCTGCAGTTTGGGCGCGAAGACGCGGCCCCGGCCACGTTGGAGCTGGCTGCGTGGG
AGCGGCGGTTCGCGGCGCCTGCACACAAGGGCGCCACCTATGTGTTCCGGCTGGCAGCGCGGGGCCGCGC
GGGGTTGGGCGAGGAGGCCGCGGCAGCGCTGAGCATCCCCGAGGACGCTCCGCGCGGCTTCCCGCAGATC
TTGGGCGCCGCGGGCAACGTGTCCGCGGGCTCCGTGCTACTGCGCTGGCTGCCACCCGTGCCCGCCGAGC
GCAACGGCGCCATCATCAAGTACACGGTGTCCGTGCGGGAGGCCGGCGCCCCTGGGCCCGCGACCGAGAC
GGAGCTGGCGGCGGCCGCCCAGCCGGGGGCCGAGACAGCGCTCACGCTGCGAGGGCTGCGGCCGGAGACG
GCCTACGAGTTACGCGTGCGCGCACACACGCGTCGCGGCCCGGGCCCCTTCTCACCCCCGCTGCGCTACA
GGCTCGCGCGGGACCCAGTCTCCCCAAAGAACTTCAAGGTGAAGATGATCATGAAGACTTCAGTGCTGCT
GAGCTGGGAGTTCCCCGACAACTATAACTCACCCACACCCTACAAGATTCAGTACAATGGGCTCACCCTG
GATGTGGACGGCCGCACGACCAAGAAGCTGATCACACACCTCAAGCCACACACCTTCTATAATTTCGTGC
TCACCAACCGTGGCAGCAGCCTGGGGGGCCTGCAGCAGACGGTCACTGCCAGGACCGCCTTTAACATGCT
CAGTGGCAAGCCTAGCGTCGCCCCGAAGCCCGACAATGACGGTTTCATCGTGGTCTACCTGCCTGATGGC
CAGAGTCCTGTGACCGTGCAGAACTACTTCATTGTGATGGTCCCACTTCGGAAGTCTCGAGGTGGCCAGT
TCCCTGTCCTACTAGGTAGTCCAGAGGACATGGATCTGGAGGAGCTCATCCAGGACATCTCCCGGCTGCA
GAGGCGCAGCCTGCGCCACTCCAGACAGCTGGAGGTGCCTCGGCCCTACATCGCCGCTCGATTCTCCATC
CTGCCAGCTGTCTTCCATCCTGGGAACCAGAAGCAATATGGTGGCTTTGACAACAGGGGCTTGGAGCCAG
GCCACCGCTATGTCCTCTTTGTGCTTGCTGTGTTGCAGAAGAATGAGCCTACATTTGCAGCCAGTCCCTT
CTCAGACCCCTTCCAGCTGGACAACCCGGACCCTCAGCCCATTGTGGACGGCGAGGAGGGCCTCATCTGG
GTGATTGGGCCTGTGCTGGCCGTGGTCTTCATCATCTGCATCGTGATTGCCATCCTGCTGTACAAGAACA
AACCTGACAGCAAACGCAAGGACTCAGAGCCCCGCACCAAATGCTTACTGAACAATGCCGACCTTGCCCC
CCATCACCCCAAGGACCCTGTGGAAATGCGACGCATCAACTTCCAGACACCAGGTATGCTCAGCCACCCA
CCCATCCCCATCACAGACATGGCGGAGCACATGGAGAGACTCAAAGCCAACGACAGCCTGAAGCTCTCCC
AGGAGTACGAGTCCATTGACCCCGGGCAGCAATTCACGTGGGAACATTCGAACCTGGAGGCCAACAAGCC
CAAGAACCGCTATGCCAACGTCATCGCCTATGACCACTCACGAGTCATCCTGCAGCCCCTAGAAGGCATC
ATGGGTAGTGATTACATCAATGCCAACTATGTGGACGGCTACCGGCGGCAGAATGCATACATTGCCACGC
AGGGGCCCCTGCCTGAGACCTTTGGGGACTTCTGGCGGATGGTGTGGGAGCAGCGATCGGCCACTGTGGT
CATGATGACGCGACTGGAGGAGAAATCACGGATCAAATGTGACCAATACTGGCCTAACCGAGGCACCGAG
ACATACGGCTTCATCCAGGTCACCCTACTAGATACCATGGAGCTGGCTACCTTCTGCGTCAGGACTTTTT
CTCTACACAAGAATGGCTCTAGCGAGAAGCGTGAGGTGCGACATTTCCAGTTCACGGCATGGCCCGACCA
CGGGGTACCTGAGTACCCCACGCCCTTCCTGGCATTCCTGCGAAGAGTCAAGACCTGCAACCCGCCTGAT
GCTGGCCCCATTGTGGTCCACTGCAGCGCGGGTGTGGGGCGCACTGGCTGCTTCATCGTAATTGACGCCA
TGCTAGAGCGCATCAAGACAGAGAAGACCGTGGATGTGTATGGACATGTGACACTCATGCGGTCGCAGCG
CAACTACATGGTGCAGACAGAGGATCAGTATGGCTTCATCCACGAGGCGCTGCTGGAGGCTGTGGGCTGC
GGCAATACCGAGGTCCCTGCTCGCAGCCTCTACACCTACATCCAGAAGCTGGCCCAGGTGGAGCCTGGCG
AGCACGTCACGGGCATGGAGCTTGAGTTCAAGAGGCTCGCCAGTTCCAAGGCACACACTTCGCGCTTCAT
CACCGCCAGCCTGCCTTGCAACAAGTTTAAGAACCGACTGGTGAACATCCTGCCGTACGAGAGCTCGCGT
GTCTGCCTGCAGCCCATCCGCGGTGTGGAGGGCTCTGACTACATCAATGCCAGCTTTATCGACGGCTATA
GACAGCAGAAAGCCTACATTGCAACACAGGGGCCACTGGCAGAGACCACAGAGGACTTCTGGCGAGCTCT
GTGGGAGAACAACTCTACTATTGTCGTAATGCTCACCAAGCTCCGAGAAATGGGCCGGGAAAAGTGCCAC
CAGTACTGGCCAGCCGAGCGCTCTGCCCGCTACCAGTACTTTGTGGTTGACCCGATGGCAGAGTATAACA
TGCCACAGTACATTCTGCGTGAGTTTAAGGTCACAGATGCCCGGGATGGCCAGTCCCGGATCCGTCCG
ACAGTTCCAGTTCACGGACTGGCCAGAGCAGGGTGCACCCAAGTCAGGGGAAGGCTTCATTGACTTCATC
GGCCAAGTGCATAAGACCAAGGAGCAGTTTGGCCAGGACGGACCCATCTCAGTGCACTGCAGCGCCGGAG
TGGGCAGGACCGGAGTGTTCATCACCCTGAGCATCGTGCTTGAGCGGATGCGCTACGAGGGCGTGGTGGA
CATTTTCCAGACAGTGAAGGTGCTTCGGACCCAGAGGCCTGCCATGGTGCAGACAGAGGACGAGTACCAG
TTCTGCTTCCAGGCGGCTTTGGAATACCTGGGCAGTTTTGATCATTATGCAACA

AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC
TGGATTACAAGGATGACGACGATAAGGTTTAA
Protein Sequence
>MR222172 representing NM_011218
Red=Cloning site Green=Tags(s)

MAPTWSPSVVSVVGPVGLFLVLLARGCLAEEPPRFIREPKDQIGVSGGVASFVCQATGDPKPRVTWNKKG
KKVNSQRFETIDFDESSGAVLRIQPLRTPRDENVYECVAQNSVGEITIHAKLTVLREDQLPPGFPNIDMG
PQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVAT
NSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPV
GRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPVVTENTATSITVTWDSGNPDPVSYY
VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV
QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLA
FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAKSETSIGLSWSAPRQESVIKYELLFREGDRGREVGRTF
DPTTAFVVEDLKPNTEYAFRLAARSPQGLGAFTAVVRQRTLQAKPSAPPQDVKCTSLRSTAILVSWRPPP
PETHNGALVGYSVRYRPLGSEDPDPKEVNNIPPTTTQILLEALEKWTEYRVTAVAYTEVGPGPESSPVVV
RTDEDVPSAPPRKVEAEALNATAIRVLWRSPTPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDIMLADAQ
EMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPADAAEDP
VLGYRLQFGREDAAPATLELAAWERRFAAPAHKGATYVFRLAARGRAGLGEEAAAALSIPEDAPRGFPQI
LGAAGNVSAGSVLLRWLPPVPAERNGAIIKYTVSVREAGAPGPATETELAAAAQPGAETALTLRGLRPET
AYELRVRAHTRRGPGPFSPPLRYRLARDPVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTL
DVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTARTAFNMLSGKPSVAPKPDNDGFIVVYLPDG
QSPVTVQNYFIVMVPLRKSRGGQFPVLLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSI
LPAVFHPGNQKQYGGFDNRGLEPGHRYVLFVLAVLQKNEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIW
VIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHP
PIPITDMAEHMERLKANDSLKLSQEYESIDPGQQFTWEHSNLEANKPKNRYANVIAYDHSRVILQPLEGI
MGSDYINANYVDGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATVVMMTRLEEKSRIKCDQYWPNRGTE
TYGFIQVTLLDTMELATFCVRTFSLHKNGSSEKREVRHFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD
AGPIVVHCSAGVGRTGCFIVIDAMLERIKTEKTVDVYGHVTLMRSQRNYMVQTEDQYGFIHEALLEAVGC
GNTEVPARSLYTYIQKLAQVEPGEHVTGMELEFKRLASSKAHTSRFITASLPCNKFKNRLVNILPYESSR
VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRALWENNSTIVVMLTKLREMGREKCH
QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRXXVRQFQFTDWPEQGAPKSGEGFIDFI
GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKVLRTQRPAMVQTEDEYQ
FCFQAALEYLGSFDHYAT

SGPTRTRPLEQKLISEEDLAANDILDYKDDDDKV
Chromatograms Chromatograms
Sequencher program is needed, download here
Restriction Sites SgfI-RsrII Cloning Scheme for this gene | Plasmid Map
ACCN NM_011218
ORF Size 5724 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_011218.1, NM_011218.2, NP_035348.2
RefSeq Size 6874 bp
RefSeq ORF 5724 bp
Locus ID 19280
UniProt ID B0V2N1
Cytogenetics 17 29.32 cM
MW 212.4 kDa
Summary Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:19833921, PubMed:21454754, PubMed:22406547). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (PubMed:21454754). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:15797710, PubMed:19833921, PubMed:19780196, PubMed:21454754, PubMed:22519304, PubMed:22406547). Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754). Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (PubMed:10080191). Functions as tyrosine phosphatase (PubMed:7529177). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (PubMed:15797710). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).UniProtKB/Swiss-Prot Function
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"NM_011218" in other vectors (2)
SKU Description Size Price
MC225026 Ptprs (untagged) - Mouse protein tyrosine phosphatase, receptor type, S (Ptprs), (10ug) 10 ug
$1,763.00
MG222172 Ptprs (tGFP-tagged) - Mouse protein tyrosine phosphatase receptor type S (Ptprs), (10ug) 10 ug
$1,803.00

Plasmid Map for MR222172

Download sequence for

file-download TXT (FASTA format)

file-download Genbank

Cloning scheme for MR222172
Circular map for MR222172

file-alt Citations

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