Ttbk2 (NM_080788) Mouse Tagged ORF Clone
- TrueORF®
SKU
MR217963
Ttbk2 (Myc-DDK-tagged) - Mouse tau tubulin kinase 2 (Ttbk2), transcript variant 1
$589.00
$1,142.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
|---|---|
| Target Symbol | Ttbk2 |
| Synonyms | 2610507N02Rik; AI326283; B930008N24Rik; mKIAA0847; Ttbk; Ttbk1; TTK |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_080788 |
| ORF Size | 3936 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_080788.3, NP_542966.2 |
| RefSeq Size | 10906 bp |
| RefSeq ORF | 3939 bp |
| Locus ID | 140810 |
| UniProt ID | Q3UVR3 |
| Cytogenetics | 2 E5 |
| MW | 144.9 kDa |
| Summary | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_080788" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MC224225 | Ttbk2 (untagged) - Mouse tau tubulin kinase 2 (Ttbk2), transcript variant 1, (10ug) | 10 ug |
$1,257.00
|
|
| MG217963 | Ttbk2 (tGFP-tagged) - Mouse tau tubulin kinase 2 (Ttbk2) transcript variant 1, (10ug) | 10 ug |
$1,342.00
|
|
| MR217963L3 | Lenti ORF clone of Ttbk2 (Myc-DDK-tagged) - Mouse tau tubulin kinase 2 (Ttbk2), transcript variant 1 | 10 ug |
$1,442.00
|
|
| MR217963L4 | Lenti ORF clone of Ttbk2 (mGFP-tagged) - Mouse tau tubulin kinase 2 (Ttbk2), transcript variant 1 | 10 ug |
$1,442.00
|
|
Citations
Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia
Mc Fie, Koneva, Collins et al
J. Cell. Sci. (2020) 133 (13) DOI: 10.1242/jcs.239871
Mc Fie, Koneva, Collins et al
J. Cell. Sci. (2020) 133 (13) DOI: 10.1242/jcs.239871
Cited by 41
AI Summary: In this study, OriGene’s anti-IFT88 antibody (clone 1A4/1H7) was used to detect IFT88 protein, enabling the authors to investigate how depletion of ciliary proteins such as IFT88 modulates inflammatory NFκB signalling independently of primary cilia.
Snippet: Therefore, we compared different antibodies to find the best one for IHC detection. MATERIALS AND METHODS: We evaluated ALK expression by four different ALK antibodies: clone D5F3 (Ventana), clone D5F3 (CST), clone 1A4/1H7 (OriGene Tech.), and clone 5A4 (Abca
Showing 1-1 of 1 papers.
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