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Hdac7 (NM_019572) Mouse Tagged ORF Clone

  • TrueORF®
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SKU
MR211253
Hdac7 (Myc-DDK-tagged) - Mouse histone deacetylase 7 (Hdac7), transcript variant 4
Interest in protein/lysate? Submit request here!
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
DDK w/ Puro mGFP w/ Puro
$589.00 $859.00
In Stock*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone
Target Symbol Hdac7
Synonyms 5830434K02Rik; HD7; HD7a; Hdac7a; mFLJ00062
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
ORF Nucleotide Sequence
>MR211253 representing NM_019572
Red=Cloning site Blue=ORF Green=Tags(s)

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGCACAGCCCCGGCGCGGGCTGCCCTGCCCTCCAGCCAGACACACCAGGCTCTCAGCCCCAACCCATGG
ACCTGCGGGTGGGCCAGCGGCCCACGGTGGAGCCCCCACCAGAGCCTGCGCTGCTGACCCTGCAACACCC
CCAACGCCTGCACCGCCATCTCTTCCTGGCAGGCTTACACCAGCAACAGCGCTCAGCCGAGCCCATGAGG
CTCTCCATGGACCCACCAATGCCGGAGCTGCAGGGGGGACAGCAGGAGCAAGAACTTCGGCAACTTCTCA
ATAAAGACAAGAGCAAGCGAAGTGCCGTAGCCAGCAGTGTGGTCAAGCAGAAGCTGGCTGAAGTGATCCT
GAAGAAACAGCAGGCAGCCCTTGAGAGAACAGTCCATCCCAGCAGCCCCAGTATTCCCTACAGAACTCTT
GAGCCCTTGGACACAGAGGGTGCTGCCCGCTCCGTGCTTAGCAGCTTCCTGCCTCCTGTTCCCAGCCTGC
CCACTGAACCCCCGGAACACTTTCCCTTGCGTAAAACAGTGTCTGAACCCAACCTGAAGTTGCGCTACAA
ACCCAAGAAATCCCTGGAGAGACGCAAGAATCCCCTGCTCAGGAAGGAGAGTGCCCCGCCCAGCCTTCGG
AGGAGGCCTGCCGAGACCCTTGGAGATTCCTCCCCCAGTAGTAGCAGCACACCCGCGTCAGGGTGCAGCT
CCCCTAATGACAGCGAGCATGGCCCTAACCCTGCCCTAGGCTCAGAGGCTGATGGTGACCGCAGGACCCA
TTCAACTTTAGGCCCTCGGGGTCCTGTACTGGGGAACCCCCATGCTCCCCTCTTCCTGCACCACGGTCTG
GAGCCAGAGGCTGGGGGCACCTTACCCTCTCGCCTGCAACCCATTCTCCTGCTGGACCCCTCAGTCTCTC
ATGCCCCACTGTGGACTGTGCCTGGCCTTGGGCCCTTGCCCTTCCACTTTGCCCAGCCCTTACTGACCAC
CGAGCGGCTCTCTGGGTCAGGCCTCCATCGACCACTTAACCGGACCCGCTCAGAGCCCCTGCCCCCCAGC
GCCACAGCCTCCCCTCTGCTGGCCCCCCTGCAGCCCCGCCAGGATCGGCTCAAACCTCACGTCCAGCTGA
TCAAGCCAGCCATCTCCCCTCCCCAGAGGCCTGCCAAGCCCAGTGAGAAGCCCCGACTGCGACAGATACC
CTCGGCTGAGGACCTAGAGACAGATGGTGGGGGAGTGGGACCTATGGCGAATGATGGCCTGGAACATAGG
GAGTCAGGCCGTGGGCCTCCTGAGGGCAGAGGCTCCATTTCTCTGCAGCAGCATCAACAGGTGCCACCCT
GGGAGCAGCAGCATCTAGCCGGGCGGCTCTCTCAGGGAAGCCCCGGGGACTCCGTGCTGATACCTCTGGC
CCAGGTTGGACACCGGCCCCTGTCCAGAACCCAGTCTTCCCCAGCAGCACCTGTCTCCCTGCTGAGCCCA
GAGCCCACCTGTCAGACCCAAGTCCTCAACAGCTCAGAGACACCTGCTACAGGGCTGGTCTATGACTCGG
TGATGCTGAAACACCAATGTTCCTGTGGAGACAACAGCAAGCATCCCGAGCATGCAGGCCGCATCCAGAG
CATCTGGTCCCGGCTGCAGGAACGGGGTCTCCGCAGCCAGTGTGAGTGTCTCCGAGGCCGAAAGGCTTCC
CTAGAGGAGCTGCAGTCAGTCCACTCTGAACGGCACGTGCTCCTCTACGGCACGAACCCACTCAGCCGCC
TCAAACTGGATAACGGGAAGCTTACAGGACTCCTGGCACAGCGGACGTTTGTGATGCTACCCTGTGGCGG
GGTTGGGGTCGATACTGACACCATCTGGAACGAGCTGCATTCCTCCAATGCAGCCCGCTGGGCTGCGGGC
AGTGTCACCGACCTTGCCTTCAAAGTAGCTTCCCGAGAGCTGAAGAATGGCTTTGCTGTGGTGCGACCCC
CGGGACACCATGCAGATCATTCTACAGCCATGGGCTTCTGCTTCTTCAACTCCGTGGCCATCGCCTGCCG
ACAGCTACAGCAACACGGCAAAGCCAGCAAGATCCTCATTGTTGACTGGGATGTTCACCATGGCAACGGC
ACACAGCAGACTTTCTACCAGGACCCCAGTGTGCTCTACATTTCCCTTCATCGCCATGACGACGGCAACT
TCTTCCCAGGCAGTGGGGCCGTGGATGAGGTGGGAACTGGCAGTGGCGAGGGCTTCAATGTCAACGTGGC
TTGGGCTGGGGGCTTGGATCCACCCATGGGGGATCCTGAGTACCTGGCTGCTTTCAGGATAGTGGTGATG
CCCATTGCCCGAGAGTTTGCTCCAGACCTGGTCCTGGTGTCTGCTGGGTTTGATGCTGCGGAGGGTCACC
CAGCCCCGCTGGGTGGCTACCATGTTTCTGCCAAATGTTTTGGGTACATGACGCAGCAGTTGATGAACTT
GGCAGGAGGCGCCGTGGTGTTGGCCTTAGAGGGTGGACATGACCTCACGGCCATCTGTGATGCCTCGGAG
GCCTGTGTAGCTGCTCTTCTGGGCAACAAGGTGGACCCCCTTTCAGAAGAAAGCTGGAAACAGAAACCCA
ACCTCAGTGCCATCCGCTCGCTGGAAGCTGTGGTCAGGGTGCACAGGAAATACTGGGGCTGCATGCAGCG
CTTGGCCTCCTGTCCAGACTCCTGGCTACCCAGAGTGCCGGGAGCTGATGCAGAAGTGGAAGCCGTGACC
GCGCTGGCATCCCTTTCTGTGGGCATCCTGGCTGAAGACAGGCCCTCGGAGCGGCTGGTGGAAGAGGAAG
AACCCATGAACCTC

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Protein Sequence
>MR211253 representing NM_019572
Red=Cloning site Green=Tags(s)

MHSPGAGCPALQPDTPGSQPQPMDLRVGQRPTVEPPPEPALLTLQHPQRLHRHLFLAGLHQQQRSAEPMR
LSMDPPMPELQGGQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPSSPSIPYRTL
EPLDTEGAARSVLSSFLPPVPSLPTEPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLR
RRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPALGSEADGDRRTHSTLGPRGPVLGNPHAPLFLHHGL
EPEAGGTLPSRLQPILLLDPSVSHAPLWTVPGLGPLPFHFAQPLLTTERLSGSGLHRPLNRTRSEPLPPS
ATASPLLAPLQPRQDRLKPHVQLIKPAISPPQRPAKPSEKPRLRQIPSAEDLETDGGGVGPMANDGLEHR
ESGRGPPEGRGSISLQQHQQVPPWEQQHLAGRLSQGSPGDSVLIPLAQVGHRPLSRTQSSPAAPVSLLSP
EPTCQTQVLNSSETPATGLVYDSVMLKHQCSCGDNSKHPEHAGRIQSIWSRLQERGLRSQCECLRGRKAS
LEELQSVHSERHVLLYGTNPLSRLKLDNGKLTGLLAQRTFVMLPCGGVGVDTDTIWNELHSSNAARWAAG
SVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQHGKASKILIVDWDVHHGNG
TQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGTGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVM
PIAREFAPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASE
ACVAALLGNKVDPLSEESWKQKPNLSAIRSLEAVVRVHRKYWGCMQRLASCPDSWLPRVPGADAEVEAVT
ALASLSVGILAEDRPSERLVEEEEPMNL

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites SgfI-MluI Cloning Scheme for this gene | Plasmid Map
ACCN NM_019572
ORF Size 2814 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_019572.3
RefSeq Size 4147 bp
RefSeq ORF 2817 bp
Locus ID 56233
UniProt ID Q8C2B3
Cytogenetics 15 F1
MW 101.7 kDa
Summary Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Positively regulates the transcriptional repressor activity of FOXP3 (By similarity). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_019572" in other vectors (3)
SKU Description Size Price
MG211253 Hdac7 (tGFP-tagged) - Mouse histone deacetylase 7A (Hdac7a) 10 ug
$1,059.00
MR211253L3 Lenti ORF clone of Hdac7 (Myc-DDK-tagged) - Mouse histone deacetylase 7 (Hdac7), transcript variant 4 10 ug
$1,159.00
MR211253L4 Lenti ORF clone of Hdac7 (mGFP-tagged) - Mouse histone deacetylase 7 (Hdac7), transcript variant 4 10 ug
$1,159.00

Plasmid Map for MR211253

Download sequence for

file-download TXT (FASTA format)

file-download Genbank

Cloning scheme for MR211253
Circular map for MR211253

file-alt Citations

A signalling pathway for transcriptional regulation of sleep amount in mice
Zhou, Wang, Li et al
Nature (2022) 612 (7940), 519-527 DOI: 10.1038/s41586-022-05510-6
Cited by 79
AI Summary: OriGene products contributed to this study by providing mouse open reading frames (ORFs) for Hdac4 (MR211598), Hdac5 (MC202550), and Hdac7 (MR211253), which were used to investigate the roles of these genes in the transcriptional regulation of sleep in mice.
Snippet: Mouse open reading frames (ORFs) of Hdac4, Hdac5, Hdac7 (MR211598, MC202550 and MR211253, respectively) were purchased from OriGene Technologies. HDAC4(S245A), HDAC4(CN) (HDAC4(S245A/S465A/S629A)), HD
Showing 1-1 of 1 papers.
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