Rps6ka4 (NM_019924) Mouse Tagged ORF Clone
- TrueORF®
SKU
MR210573
Rps6ka4 (Myc-DDK-tagged) - Mouse ribosomal protein S6 kinase, polypeptide 4 (Rps6ka4)
$589.00
$709.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
|---|---|
| Target Symbol | Rps6ka4 |
| Synonyms | 90kDa; 1110069D02Rik; AI848992; mMSK2; Msk2 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_019924 |
| ORF Size | 2319 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_019924.1, NM_019924.2, NP_064308.1 |
| RefSeq Size | 3152 bp |
| RefSeq ORF | 2322 bp |
| Locus ID | 56613 |
| UniProt ID | Q9Z2B9 |
| Cytogenetics | 19 A |
| MW | 85.7 kDa |
| Summary | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity).UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_019924" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MC200919 | Rps6ka4 (untagged) - Mouse ribosomal protein S6 kinase, polypeptide 4 (Rps6ka4), (10ug) | 10 ug |
$709.00
|
|
| MG210573 | Rps6ka4 (tGFP-tagged) - Mouse ribosomal protein S6 kinase, polypeptide 4 (Rps6ka4) | 10 ug |
$909.00
|
|
| MR210573L3 | Lenti ORF clone of Rps6ka4 (Myc-DDK-tagged) - Mouse ribosomal protein S6 kinase, polypeptide 4 (Rps6ka4) | 10 ug |
$1,009.00
|
|
| MR210573L4 | Lenti ORF clone of Rps6ka4 (mGFP-tagged) - Mouse ribosomal protein S6 kinase, polypeptide 4 (Rps6ka4) | 10 ug |
$1,009.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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