Relb (NM_009046) Mouse Tagged ORF Clone
- TrueORF®
SKU
MR208842
Relb (Myc-DDK-tagged) - Mouse avian reticuloendotheliosis viral (v-rel) oncogene related B (Relb)
$289.00
$520.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
|---|---|
| Target Symbol | Relb |
| Synonyms | shep |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_009046 |
| ORF Size | 1674 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_009046.2, NP_033072.2 |
| RefSeq Size | 2218 bp |
| RefSeq ORF | 1677 bp |
| Locus ID | 19698 |
| UniProt ID | Q04863 |
| Cytogenetics | 7 9.93 cM |
| MW | 60.3 kDa |
| Summary | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (By similarity).UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_009046" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MC203717 | Relb (untagged) - Mouse avian reticuloendotheliosis viral (v-rel) oncogene related B (Relb), (10ug) | 10 ug |
$520.00
|
|
| MG208842 | Relb (tGFP-tagged) - Mouse avian reticuloendotheliosis viral (v-rel) oncogene related B (Relb) | 10 ug |
$489.00
$720.00
|
|
| MR208842L3 | Lenti ORF clone of Relb (Myc-DDK-tagged) - Mouse avian reticuloendotheliosis viral (v-rel) oncogene related B (Relb) | 10 ug |
$820.00
|
|
| MR208842L4 | Lenti ORF clone of Relb (mGFP-tagged) - Mouse avian reticuloendotheliosis viral (v-rel) oncogene related B (Relb) | 10 ug |
$820.00
|
|
Citations
Co-occupancy identifies transcription factor co-operation for axon growth
Venkatesh, Mehra, Wang et al
Nat Commun (2021) 12 (1), 2555 DOI: 10.1038/s41467-021-22828-3
Venkatesh, Mehra, Wang et al
Nat Commun (2021) 12 (1), 2555 DOI: 10.1038/s41467-021-22828-3
Cited by 21
AI Summary: OriGene contributed to this study by providing constructs for candidate transcription factor genes, which were used to test their cooperative effects on axon growth.
Snippet: tch had genes belonging to one functional subnetwork to identify Klf6 synergizers by functional category. Cloning and virus production Constructs for candidate genes were purchased from Dharmacon or Origene, and relevant accession numbers for all 62 candidate TFs are summarized in Supplementary Data 2. mScarlet was a gift from Dorus Gadella (RRID:Addgene_85044), pAAV-CAG-tdTomato (codon diversif;...
Showing 1-1 of 1 papers.
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