Traf6 (NM_009424) Mouse Tagged ORF Clone
$289.00
$741.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
|---|---|
| Target Symbol | Traf6 |
| Synonyms | 2310003F17Rik; AI851288; C630032O20Rik |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_009424 |
| ORF Size | 1590 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_009424.3, NP_033450.2 |
| RefSeq Size | 5536 bp |
| RefSeq ORF | 1593 bp |
| Locus ID | 22034 |
| UniProt ID | P70196 |
| Cytogenetics | 2 E2 |
| MW | 60.1 kDa |
| Summary | This gene encodes a member of the TNF receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin ligase activity. Alternate splicing of this gene results in multiple transcript variants. provided by RefSeq, Dec 2014 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_009424" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MC217548 | Traf6 (untagged) - Mouse TNF receptor-associated factor 6 (Traf6), (10ug) | 10 ug |
$544.00
|
|
| MG208489 | Traf6 (tGFP-tagged) - Mouse Tnf receptor-associated factor 6 (Traf6) | 10 ug |
$489.00
$941.00
|
|
| MR208489L3 | Lenti ORF clone of Traf6 (Myc-DDK-tagged) - Mouse TNF receptor-associated factor 6 (Traf6) | 10 ug |
$1,041.00
|
|
| MR208489L4 | Lenti ORF clone of Traf6 (mGFP-tagged) - Mouse TNF receptor-associated factor 6 (Traf6) | 10 ug |
$1,041.00
|
|
Citations
The dinitrothiophenol SN-2 reduces osteoclastogenesis and estrogen deficiency-induced bone loss by inhibiting TRAF6 auto-ubiquitination
Lu, Wang, Wang et al
Bone Reports (2026)
Lu, Wang, Wang et al
Bone Reports (2026)
The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation
Du, Yuan, Tan et al
Nat Commun (2017) 8 (1), 2049 DOI: 10.1038/s41467-017-02229-1
Du, Yuan, Tan et al
Nat Commun (2017) 8 (1), 2049 DOI: 10.1038/s41467-017-02229-1
AI Summary: OriGene contributed to this study by providing the wild-type TRAF6 plasmid (MR208489), which was used to investigate the molecular interactions between Mirt2 and TRAF6 in the regulation of inflammation.
Snippet: The wild-type TRAF6 plasmid was obtained from ORIGENE (MR208489), and the truncated constructs of TRAF6 (1–259aa, 1–357aa, 260–530aa, 358–530aa, 1–149aa, 150–259aa) were prepared by PCR and cloned into pCMV6-Entry mammalian vector with C-terminal Myc tag
Showing 1-2 of 2 papers.
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