Pltp (NM_011125) Mouse Tagged ORF Clone
$289.00
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
|---|---|
| Target Symbol | Pltp |
| Synonyms | Bpife; OD107 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_011125 |
| ORF Size | 1479 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_011125.2, NP_035255.1 |
| RefSeq Size | 1806 bp |
| RefSeq ORF | 1482 bp |
| Locus ID | 18830 |
| UniProt ID | P55065 |
| Cytogenetics | 2 85.27 cM |
| MW | 54.5 kDa |
| Summary | Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability (By similarity).UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_011125" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MC216773 | Pltp (untagged) - Mouse phospholipid transfer protein (Pltp), (10ug) | 10 ug |
$503.00
|
|
| MG207917 | Pltp (tGFP-tagged) - Mouse phospholipid transfer protein (Pltp) | 10 ug |
$657.00
|
|
| MR207917L3 | Lenti ORF clone of Pltp (Myc-DDK-tagged) - Mouse phospholipid transfer protein (Pltp) | 10 ug |
$757.00
|
|
| MR207917L4 | Lenti ORF clone of Pltp (mGFP-tagged) - Mouse phospholipid transfer protein (Pltp) | 10 ug |
$757.00
|
|
Citations
The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication
Sponton, Hosono, Taura et al
EMBO Rep. (2020)
Sponton, Hosono, Taura et al
EMBO Rep. (2020)
Cited by 51
AI Summary: OriGene products contributed to this paper by providing the PLTP cDNA clone (OriGene, Cat# RC210489), which was used for overexpression studies to investigate the role of PLTP as a batokine in glucose and lipid homeostasis.
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