Camk2a (NM_177407) Mouse Tagged ORF Clone
- TrueORF®
SKU
MR207662
Camk2a (Myc-DDK-tagged) - Mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a), transcript variant 2
$289.00
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
|---|---|
| Target Symbol | Camk2a |
| Synonyms | CaMKII; mKIAA0968; R74975 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_177407 |
| ORF Size | 1434 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_177407.4 |
| RefSeq Size | 4949 bp |
| RefSeq ORF | 1437 bp |
| Locus ID | 12322 |
| UniProt ID | P11798 |
| Cytogenetics | 18 34.41 cM |
| MW | 54.6 kDa |
| Summary | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons (By similarity). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378).UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_177407" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MC206017 | Camk2a (untagged) - Mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a), transcript variant 2, (10ug) | 10 ug |
$457.00
|
|
| MG207662 | Camk2a (tGFP-tagged) - Mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a), transcript variant 2 | 10 ug |
$489.00
$657.00
|
|
| MR207662L3 | Lenti ORF clone of Camk2a (Myc-DDK-tagged) - Mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a), transcript variant 2 | 10 ug |
$757.00
|
|
| MR207662L4 | Lenti ORF clone of Camk2a (mGFP-tagged) - Mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a), transcript variant 2 | 10 ug |
$757.00
|
|
Citations
Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity
Fiumelli, Herrera-López, Lemtiri-Chlieh et al
J Physiol (2026)
Fiumelli, Herrera-López, Lemtiri-Chlieh et al
J Physiol (2026)
AI Summary: OriGene’s pCMV6-Entry vector expressing CaMKIIα (MR207662) was used in this study to investigate the role of CaMKII in lactate-induced modulation of NMDA receptor function.
Snippet: These plasmids were sourced from GenScript (Singapore). In addition we obtained a pCMV6-Entry vector expressing CaMKIIα (MR207662, accession NM_177407) from OriGene (Rockville, MD, USA)
Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting cysteines in the C-terminal domain of GluN2B subunits: implications for synaptic plasticity
Fiumelli, Herrera-López, Lemtiri-Chlieh et al
bioRxiv (2024)
Fiumelli, Herrera-López, Lemtiri-Chlieh et al
bioRxiv (2024)
Cited by 3
Snippet: … These plasmids were sourced from GenScript. In addition, we obtained a pCMV6-Entry vector expressing CaMKIIα (MR207662, accession NM_177407) from OriGene. …
Redox-sensitive calcium/calmodulin-dependent protein kinase IIα in angiotensin II intra-neuronal signaling and hypertension
Basu, Case, Liu et al
Redox Biol (2019) 27, 101230 DOI: 10.1016/j.redox.2019.101230
Basu, Case, Liu et al
Redox Biol (2019) 27, 101230 DOI: 10.1016/j.redox.2019.101230
Cited by 18
AI Summary: In this study, OriGene's mouse CaMKIIα cDNA (Cat# MR206316) and CaMKIIα antibody (Cat# TA309594) were used to overexpress and detect CaMKIIα in neurons, enabling the authors to investigate its redox sensitivity and role in angiotensin II-mediated neuronal signaling and hypertension.
Showing 1-3 of 3 papers.
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