Ppard (NM_011145) Mouse Tagged ORF Clone
- TrueORF®
SKU
MR207001
Ppard (Myc-DDK-tagged) - Mouse peroxisome proliferator activator receptor delta (Ppard)
$686.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
|---|---|
| Target Symbol | Ppard |
| Synonyms | Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta; Pparb; Pparb/d; PPARdelta; PPARb |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-RsrII Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_011145 |
| ORF Size | 1530 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_011145.2 |
| RefSeq Size | 3240 bp |
| RefSeq ORF | 1323 bp |
| Locus ID | 19015 |
| UniProt ID | P35396, Q546I3 |
| Cytogenetics | 17 14.64 cM |
| MW | 49.7 kDa |
| Summary | Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity).UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_011145" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MC215772 | Ppard (untagged) - Mouse peroxisome proliferator activator receptor delta (Ppard), (10ug) | 10 ug |
$457.00
|
|
| MG207001 | Ppard (tGFP-tagged) - Mouse peroxisome proliferator activator receptor delta (Ppard) | 10 ug |
$886.00
|
|
| MR207001L3 | Lenti ORF clone of Ppard (Myc-DDK-tagged) - Mouse peroxisome proliferator activator receptor delta (Ppard) | 10 ug |
$986.00
|
|
| MR207001L4 | Lenti ORF clone of Ppard (mGFP-tagged) - Mouse peroxisome proliferator activator receptor delta (Ppard) | 10 ug |
$986.00
|
|
Citations
All-trans retinoic acid suppresses systemic inflammation induced by severe fever with thrombocytopenia syndrome virus in mice
Yu, Wu, Yin et al
Nat Microbiol (2026) 11 (8), 2279-2293 DOI: 10.1038/s41564-026-02411-6
Yu, Wu, Yin et al
Nat Microbiol (2026) 11 (8), 2279-2293 DOI: 10.1038/s41564-026-02411-6
AI Summary: OriGene products, specifically the mouse PPARγ-LBD (variant 2; MR208132) and PPARβ/δ-LBD (MR207001) expression plasmids, were used in co-transfection experiments to investigate the molecular mechanisms by which all-trans retinoic acid modulates inflammatory signaling in SFTSV-infected cells.
Snippet: HEK293T cells seeded in 24-well plates (70–80% confluency) were co-transfected with expression plasmids encoding mouse PPARγ-LBD (variant 2;MR208132, OriGene) or PPARβ/δ-LBD (MR207001, OriGene), along with the PPRE‑driven firefly luciferase reporter54 (consisting of the nucleotide sequence 5
PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically
Dickey, Pineda, Tsunemi et al
Nat Med (2016) 22 (1), 37-45 DOI: 10.1038/nm.4003
Dickey, Pineda, Tsunemi et al
Nat Med (2016) 22 (1), 37-45 DOI: 10.1038/nm.4003
Cited by 108
AI Summary: In this study, OriGene’s PPAR-delta (PPARD) cDNA clone (Cat# SC119291) was used to investigate the role of PPAR-δ in neuronal function and Huntington's disease models.
Showing 1-2 of 2 papers.
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