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Pvrl2 (BC009088) Mouse Tagged ORF Clone

  • TrueORF®
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SKU
MG207475
Pvrl2 (tGFP-tagged) - Mouse poliovirus receptor-related 2 (cDNA clone MGC:6320 IMAGE:2812478)
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$489.00 $657.00
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Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone
Target Symbol Pvrl2
Synonyms MPH, nectin-2, Cd112
Vector pCMV6-AC-GFP
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Restriction Sites SgfI-MluI Cloning Scheme for this gene | Plasmid Map
ACCN BC009088
ORF Size 1401 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq BC009088, AAH09088
RefSeq Size 1907 bp
RefSeq ORF 1403 bp
Locus ID 19294
Cytogenetics 7 9.94 cM
Summary Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein.UniProtKB/Swiss-Prot Function
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Documents
Resources

Plasmid Map for MG207475

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file-download TXT (FASTA format)

file-download Genbank

Cloning scheme for MG207475
Circular map for MG207475

file-alt Citations

Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors
Tsou, Wren, Amin et al
Arthritis & rheumatology (2016) 68 (12), 2975-2985 DOI: 10.1002/art.39828
Cited by 72
AI Summary: OriGene products—specifically FSTL1 and PVRL2 (pCMV6-XL5 vectors) and CYR61 (pCMV6-XL4 vector)—were used to overexpress these genes in endothelial cells, enabling the authors to demonstrate their functional roles in regulating angiogenesis in scleroderma.
Snippet: Overexpression of PVRL2, FSTL1, and CYR61 was performed as previously described with some modification (4). ECs were transfected with 0.33 μg of FSTL1, PVRL2 (both from Origene;control vector pCMV6-XL5), or 1.65 μg of CYR61 (Origene;control vector pCMV6-XL4) and lipofectamine 2000 (Invitrogen) for 24 hours in T12.5 flasks
FigureFigure
Showing 1-1 of 1 papers.
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