Cav1 (NM_007616) Mouse Tagged ORF Clone
$489.00
$500.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
|---|---|
| Target Symbol | Cav1 |
| Synonyms | Cav; Cav-1 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_007616 |
| ORF Size | 534 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_007616.4 |
| RefSeq Size | 2487 bp |
| RefSeq ORF | 537 bp |
| Locus ID | 12389 |
| UniProt ID | P49817 |
| Cytogenetics | 6 A2 |
| Summary | May act as a scaffolding protein within caveolar membranes (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19546242). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (PubMed:10816572). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_007616" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MC202054 | Cav1 (untagged) - Mouse caveolin 1, caveolae protein (Cav1), (10ug) | 10 ug |
$300.00
|
|
| MR201562 | Cav1 (Myc-DDK-tagged) - Mouse caveolin 1, caveolae protein (Cav1) | 10 ug |
$289.00
$300.00
|
|
| MR201562L3 | Lenti ORF clone of Cav1 (Myc-DDK-tagged) - Mouse caveolin 1, caveolae protein (Cav1) | 10 ug |
$600.00
|
|
| MR201562L4 | Lenti ORF clone of Cav1 (mGFP-tagged) - Mouse caveolin 1, caveolae protein (Cav1) | 10 ug |
$600.00
|
|
Citations
Caveolin-1 gene therapy inhibits inflammasome activation to protect from bleomycin-induced pulmonary fibrosis
Lin, Barravecchia, Matthew Kottmann et al
Sci Rep (2019) 9 (1), 19643 DOI: 10.1038/s41598-019-55819-y
Lin, Barravecchia, Matthew Kottmann et al
Sci Rep (2019) 9 (1), 19643 DOI: 10.1038/s41598-019-55819-y
Cited by 38
AI Summary: In this study, the OriGene pCMV-Cav1 plasmid, which expresses a GFP-tagged mouse Caveolin-1 protein, was used to investigate the therapeutic effects of Cav-1 overexpression in reducing inflammasome activation and protecting against bleomycin-induced pulmonary fibrosis.
Snippet: …pCMV-Cav1 expresses a GFP- tagged mouse caveolae protein 1 (Cav1) from the CMV promoter (Origene, Rockville, MD), and pUbC-Cav1 expresses a GFP-tagged mouse Cav1 from the ubiquitin (UbC) promoter cloned from pUbC-GFP and pCMV-Cav1 plasmids. …pCMV-Cav1 expresses a GFP- tagged mouse caveolae protein 1 (Cav1) from the CMV promoter (Origene, Rockville, MD), and pUbC-Cav1 expresses a GFP-tagged mouse Cav1 from the ubiquitin (UbC) promoter cloned from pUbC-GFP and pCMV-Cav1 plasmids. …
Showing 1-1 of 1 papers.
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